Does topical voriconazole trigger dysplastic changes on the ocular surface?

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dc.contributor.authorPalamar, Melis
dc.contributor.authorEgrilmez, Sait
dc.contributor.authorYilmaz, Suzan Guven
dc.contributor.authorPolat, Suleyha Hilmioglu
dc.contributor.authorGunduz, Omur Ucakhan
dc.date.accessioned2019-10-27T22:28:12Z
dc.date.available2019-10-27T22:28:12Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: Systemic voriconazole treatment was reported to cause photosensitivity and related cutaneous malignancies. The aim of this report is to demonstrate a graft-related Candida endophthalmitis case that developed ocular surface dysplastic changes after receiving topical 1% voriconazole treatment. Methods: Full ocular examination, photography, and in vivo confocal microscopy examination (Rostock Cornea Module/HRT II, Heidelberg, Germany) were performed. Results: A 73-year-old male with graft-related Candida endophthalmitis that was on topical 1% voriconazole for 4 months developed a whitish gelatinous lesion on the cornea originating from the nasal limbus. In vivo confocal microscopy examination revealed mild dysplastic changes in the cornea epithelium. Conclusion: Topical voriconazole might trigger neoplastic changes on the ocular surface as reported with systemic use in other sun-exposed parts of the body. Further studies are needed to relate topical use of voriconazole with ocular surface dysplasia.en_US
dc.identifier.doi10.1179/1973947814Y.0000000166en_US
dc.identifier.endpage113en_US
dc.identifier.issn1120-009X
dc.identifier.issn1973-9478
dc.identifier.issue2en_US
dc.identifier.pmid24621171en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://doi.org/10.1179/1973947814Y.0000000166
dc.identifier.urihttps://hdl.handle.net/11454/50861
dc.identifier.volume27en_US
dc.identifier.wosWOS:000351060700009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherManey Publishingen_US
dc.relation.ispartofJournal of Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCandidaen_US
dc.subjectConfocal microscopyen_US
dc.subjectCorneaen_US
dc.subjectDysplasiaen_US
dc.subjectPenetrating keratoplastyen_US
dc.subjectVoriconazoleen_US
dc.titleDoes topical voriconazole trigger dysplastic changes on the ocular surface?en_US
dc.typeArticleen_US

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