Impression Cytologic Evaluation of the Conjunctiva in Patients Treated with Topical 1% Voriconazole

Basit Öğe Kaydı
dc.authoridPalamar, Melis/0000-0002-2494-0131
dc.authoridVERAL, ALI/0000-0003-0343-9978
dc.authoridDegirmenci, Cumali/0000-0002-8268-536X
dc.contributor.authorDegirmenci, Cumali
dc.contributor.authorPalamar, Melis
dc.contributor.authorEkin, Zuebeyde
dc.contributor.authorSelver, Ozlem Barut
dc.contributor.authorVeral, Ali
dc.contributor.authorYagci, Ayse
dc.date.accessioned2024-08-31T07:48:25Z
dc.date.available2024-08-31T07:48:25Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: The aim of the present study was to evaluate any conjunctival metaplastic changes by impression cytology in patients who underwent topical 1% voriconazole treatment for severe fungal keratitis. Materials and Methods: The study was conducted at Ege University Faculty of Medicine, Departments of Ophthalmology and Medical Pathology. Patients who were treated with 1% topical voriconazole for fungal keratitis for at least 3 months were included. The used topical voriconazole treatment was initiated as one drop every hour and was tapered according to clinical improvement in all patients. Treatment was continued 4 times a day for at least 3 months. Impression cytology samples were collected at least 3 months after cessation of topical voriconazole from the affected eyes and from the fellow eyes as a control group. Collected specimens were transferred to the pathology department for evaluation and grading (Nelson's grading system). Results: The mean age of the patients was 57.68 +/- 17.32 years (range, 22-87 years). The impression cytology grade of the inferior bulbar conjunctiva was 1.73 +/- 0.77 (range, 0-3) in the study group and 1.19 +/- 0.98 (range, 0-3) in the control group (p=0.03). The impression cytology grade of the temporal bulbar conjunctiva was 1.69 +/- 0.73 (range, 0-3) in the study group and 1.15 +/- 0.88 (range, 0-3) in the control group (p=0.02). The impression cytology grades of the nasal and superior bulbar conjunctiva did not differ statistically (p values 0.13 and 0.17, respectively). Conclusion: Topical voriconazole is an effective broad-spectrum antifungal drug, but it induces conjunctival squamous metaplasia. Clinicians should be aware of this possible side effect of topical voriconazole and should carefully evaluate the conjunctiva of treated patients at each visit to detect possible metaplastic changes.en_US
dc.description.sponsorshipEge University Scientific Research Project Foundation [18-TIP-005]en_US
dc.description.sponsorshipFinancial Disclosure: The study was funded by the Ege University Scientific Research Project Foundation (project number: 18-TIP-005) .en_US
dc.identifier.doi10.4274/tjo.galenos.2023.20268
dc.identifier.endpage4en_US
dc.identifier.issn1300-0659
dc.identifier.issn2147-2661
dc.identifier.issue1en_US
dc.identifier.pmid38008933en_US
dc.identifier.scopus2-s2.0-85185708693en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.4274/tjo.galenos.2023.20268
dc.identifier.urihttps://hdl.handle.net/11454/104783
dc.identifier.volume54en_US
dc.identifier.wosWOS:001171844900004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurk Oftalmoloji Dergisi-Turkish Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectFungal Keratitisen_US
dc.subjectVoriconazoleen_US
dc.subjectImpression Cytologyen_US
dc.subjectMetaplasiaen_US
dc.titleImpression Cytologic Evaluation of the Conjunctiva in Patients Treated with Topical 1% Voriconazoleen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu