The Effect of Lavandula stoechas on Wound Healing in an Experimental Diabetes Model

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dc.authoridTOYGAR, İsmail/0000-0003-3065-5756
dc.authoridSoylu, Fahri Emrah/0000-0002-8405-5468
dc.contributor.authorDemir, Derya
dc.contributor.authorToygar, Ismail
dc.contributor.authorSoylu, Emrah
dc.contributor.authorAksu, Ali Tarik
dc.contributor.authorTureyen, Aynur
dc.contributor.authorYildirim, Ilgin
dc.contributor.authorCetinkalp, Sevki
dc.date.accessioned2024-08-31T07:50:43Z
dc.date.available2024-08-31T07:50:43Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Diabetic foot is a consequential and dangerous complication of diabetes, contributing to decreased quality of life, escalated hospitalizations, and increased mortality rates. Using an experimental model of diabetes, this study aims to investigate the effect of Lavandula stoechas on wound healing.Methods: A total of 35 albino Wistar rats, 250-350 grams in weight, were used. The rats were divided into five groups, seven rats in each group. Of these, 21 rats were induced with 50 mg/kg streptozotocin (STZ) to mimic the diabetic condition. Additionally, 14 rats remained non-diabetic and served as the control group. The diabetic rats were further divided into three subgroups. The non-diabetic group was split into two subgroups based on the dressing materials used (allicin, physiological serum, and control). Wound dimensions were assessed on Days 0, 7, 14, and 21. Biopsies were taken from the wound sites at the same time.Results: There were significant differences between groups on Days 7, 14, and 21. The percentage of healing was highest in the Lavandula Stoechas group on Days 7, 14, and 21. Microscopic examination of the biopsies supported accelerated wound healing on Days 7 and 14. Reduced mononuclear cell density and increased hair follicle and adipose tissue development were observed in the DM (diabetes mellitus)-Lavandula Stoechas group on Day 7. On Day 14, the DM-Lavandula Stoechas group increased collagen levels and hair follicles. Similarly, the non-DM-Lavandula Stoechas group showed reduced bullae, dermal edema, and intraepithelial edema on Day 7. This was followed by increased fibroblast levels on Day 14.Conclusions: In conclusion, this study provides compelling evidence for the potential of Lavandula stoechas extract in the enhancement of diabetic wound healing. The multiple interactions revealed here highlight the need for further investigation into the underlying mechanisms. A cost-effective use of Lavandula stoechas opens up promising prospects in managing diabetic foot healing. This warrants additional research and clinical translation.en_US
dc.identifier.doi10.7759/cureus.45001
dc.identifier.issn2168-8184
dc.identifier.issue9en_US
dc.identifier.pmid37829966en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.45001
dc.identifier.urihttps://hdl.handle.net/11454/105331
dc.identifier.volume15en_US
dc.identifier.wosWOS:001106812600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofCureus Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectWound Healingen_US
dc.subjectRaten_US
dc.subjectLavandula Stoechasen_US
dc.subjectDiabetic Footen_US
dc.subjectDiabetesen_US
dc.titleThe Effect of Lavandula stoechas on Wound Healing in an Experimental Diabetes Modelen_US
dc.typeArticleen_US

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