PDCD1 polymorphisms are not associated with Takayasu's arteritis in Turkey

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dc.contributor.authorDireskeneli, H.
dc.contributor.authorTuna-Erdogan, E.
dc.contributor.authorGunduz, F.
dc.contributor.authorBandurska-Luque, A.
dc.contributor.authorAlparslan, B.
dc.contributor.authorKebe, M.
dc.contributor.authorUyar, F. A.
dc.contributor.authorBicakcigil, M.
dc.contributor.authorAksu, K.
dc.contributor.authorKamali, S.
dc.contributor.authorOzbalkan, Z.
dc.contributor.authorAtes, A.
dc.contributor.authorKaradag, O.
dc.contributor.authorOzer, H. T. E.
dc.contributor.authorAkar, S.
dc.contributor.authorOnen, F.
dc.contributor.authorSeyahi, E.
dc.contributor.authorOnat, A. M.
dc.contributor.authorAydin, S. Z.
dc.contributor.authorYilmaz, N.
dc.contributor.authorCefle, A.
dc.contributor.authorCobankara, V.
dc.contributor.authorTunc, E.
dc.contributor.authorOzturk, M. A.
dc.contributor.authorFresko, I.
dc.contributor.authorKaraaslan, Y.
dc.contributor.authorAkkoc, N.
dc.contributor.authorYucel, A. E.
dc.contributor.authorKiraz, S.
dc.contributor.authorKeser, G.
dc.contributor.authorInanc, M.
dc.contributor.authorSaruhan-Direskeneli, G.
dc.date.accessioned2019-10-27T21:34:05Z
dc.date.available2019-10-27T21:34:05Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives. Takayasu's arteritis (TA) is a chronic arterial inflammation of unknown etiology involving mainly the aorta and its major branches. Based on the associations of programmed death-1 (PD-1) protein encoding gene (PDCD1) with connective tissue diseases and vasculitides, PDCD1 polymorphisms are studied for susceptibility to TA in this study. Methods. The study group is made up of TA patients (n=229) fulfilling the 1990 ACR classification criteria and compared to 193 healthy controls (HC). PD-1.3, PD-1.5 and PD-1.6 single nucleotide polymorphisms of PDCD1 gene are genotyped by polymerase chain reaction and restriction analysis (PCR-RFLP). Results. The distribution of PD-1.5 polymorphism in TA patients and HC revealed a similar presence of TT genotype in patients and controls (13.3% vs. 11.4%). PD-1.3 and PD-1.6 were less polymorphic and did not differ between the groups. Rare AA genotype of PD-1.3 (1.4% vs. 1.0%) and AG genotype of PD-1.6 was again similarly (22.4% vs. 19.2%) present in TA and HC. Conclusion. PD-1.3, 1.5 and 1.6 polymorphisms of PDCD1 gene, which were shown to be associated with various autoimmune disorders and vasculitides, are not associated with a susceptibility to TA in Turkish population.en_US
dc.description.sponsorshipIstanbul UniversityIstanbul University; Marmara UniversityMarmara Universityen_US
dc.description.sponsorshipThis study was supported by Istanbul and Marmara University Research Funds.en_US
dc.identifier.endpageS14en_US
dc.identifier.issn0392-856X
dc.identifier.issue1en_US
dc.identifier.pmid22274654en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageS11en_US
dc.identifier.urihttps://hdl.handle.net/11454/45549
dc.identifier.volume30en_US
dc.identifier.wosWOS:000304499000005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClinical & Exper Rheumatologyen_US
dc.relation.ispartofClinical and Experimental Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTakayasu's arteritisen_US
dc.subjectPDCD1en_US
dc.subjectprogrammed cell deathen_US
dc.titlePDCD1 polymorphisms are not associated with Takayasu's arteritis in Turkeyen_US
dc.typeArticleen_US

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