Using dynein heavy chain 5 and creatine kinase levels in cervical fluid and blood for early diagnosing of ectopic pregnancy

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dc.contributor.authorSahin, Cagdas
dc.contributor.authorUygun, Zihni O.
dc.contributor.authorHortu, Ismet
dc.contributor.authorAkdemir, Ali
dc.contributor.authorKocamanoglu, Meltem
dc.contributor.authorErgenoglu, Ahmet M.
dc.contributor.authorAkcay, Yasemin
dc.date.accessioned2021-05-03T20:33:36Z
dc.date.available2021-05-03T20:33:36Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractAim Ectopic pregnancy is a life-threatening problem in reproductive ages. Diagnosing ectopic pregnancy in the early period provides to reducing mortality and morbidity and gives an opportunity for medical treatment to preserve fallopian tubes. Evaluation of cervical fluid for determining ectopic pregnancy with new promising markers provided different aspects for diagnosing ectopic pregnancy in the present study. Methods in this prospective clinical study, ectopic pregnant patients as ectopic pregnancy group (n = 46), intrauterine pregnant patients as intrauterine pregnancy group (n = 29) and not-pregnant patients as nonpregnancy group (n = 10) participated to study. Cervical fluid samples were collected with using merocel sponge. in addition, serum samples were obtained from patients. Dynein heavy chain 5 (DNAH5) and creatine kinase (CK) levels were determined by enzyme-linked immunosorbent assay kits in samples. Results Reduced cervical fluid DNAH5 levels was diagnosed in ectopic pregnancy group compared to intrauterine pregnancy group (median 3.42 ng/mL; 25-75% percentile 0-9.56 ng/mL vs median 6.14 ng/mL; 1.40-8.31 ng/mL; P < 0.001). on the other hand, DNAH5 protein was not detected in nonpregnant patients' samples. in addition, statistical significant increased cervical fluid CK levels were diagnosed in ectopic pregnancy group compared to intrauterine pregnancy group (median 4477.61 IU/L; 0-64 925.37 IU/L vs 0 IU/L; 0-6832.30 IU/L; P = 0.006). Conclusion Measuring of CK and DNAH5 in cervical fluid could be promising markers for early diagnosing of ectopic pregnancy. Decreased DNAH5 levels in cervical fluid might be result from abnormal cilia function in ectopic pregnant patients. ClinicalTrials.gov ID. NCT02995356.en_US
dc.identifier.doi10.1111/jog.14616en_US
dc.identifier.endpage927en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue3en_US
dc.identifier.pmid33336538en_US
dc.identifier.scopus2-s2.0-85097660507en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage921en_US
dc.identifier.urihttps://doi.org/10.1111/jog.14616
dc.identifier.urihttps://hdl.handle.net/11454/70084
dc.identifier.volume47en_US
dc.identifier.wosWOS:000599522600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcervical fluiden_US
dc.subjectcreatine kinaseen_US
dc.subjectdynein heavy chain5en_US
dc.subjectectopic pregnancyen_US
dc.titleUsing dynein heavy chain 5 and creatine kinase levels in cervical fluid and blood for early diagnosing of ectopic pregnancyen_US
dc.typeArticleen_US

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