Associations of Triiodothyronine Levels with Carotid Atherosclerosis and Arterial Stiffness in Hemodialysis Patients

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dc.contributor.authorTatar, Erhan
dc.contributor.authorKircelli, Fatih
dc.contributor.authorAsci, Gulay
dc.contributor.authorCarrero, Juan Jesus
dc.contributor.authorGungor, Ozkan
dc.contributor.authorDemirci, Metem Sezis
dc.contributor.authorOzbek, Suha Sureyya
dc.contributor.authorCeylan, Naim
dc.contributor.authorOzkahya, Mehmet
dc.contributor.authorToz, Huseyin
dc.contributor.authorOk, Ercan
dc.date.accessioned2019-10-27T21:36:37Z
dc.date.available2019-10-27T21:36:37Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and objectives End-stage renal disease is linked to alterations in thyroid hormone levels and/or metabolism, resulting in a high prevalence of subclinical hypothyroidism and low triiodothyronine (T3) levels. These alterations are involved in endothelial damage, cardiac abnormalities, and inflammation, but the exact mechanisms are unclear. In this study, we investigated the relationship between serum free-T3 (fT3) and carotid artery atherosclerosis, arterial stiffness, and vascular calcification in prevalent patients on conventional hemodialysis. Design, setting, participants, & measurements 137 patients were included. Thyroid-hormone levels were determined by chemiluminescent immunoassay, carotid artery intima media thickness (CA-IMT) by Doppler ultrasonography, carotid-femoral pulse wave velocity (c-f PWV), and augmentation index by Sphygrnocor device, and coronary artery calcification (CAC) scores by multi-slice computerized tomography. Results Mean fT3 level was 3.70 +/- 1.23 pmol/L. Across decreasing fT3 tertiles, c-f PWV and CA-IMT values were incrementally higher, whereas CACs were not different. In adjusted ordinal logistic regression analysis, fT3 level (odds ratio, 0.81; 95% confidence interval, 0.68 to 0.97), age, and interdialytic weight gain were significantly associated with CA-IMT. fT3 level was associated with c-f PWV in nondiabetics but not in diabetics. In nondiabetics (11 = 113), c-f PWV was positively associated with age and systolic BP but negatively with fT3 levels (odds ratio = 0.57, 95% confidence interval 0.39 to 0.83). Conclusions fT3 levels are inversely associated with carotid atherosclerosis but not with CAC in hemodialysis patients. Also, fT3 levels are inversely associated with surrogates of arterial stiffness in nondiabetics. Clin J Am Soc Nephrol 6: 2240-2246, 2011. doi:10.2215/CJN.02540311en_US
dc.description.sponsorshipLoo and Hans Ostermans Foundation; Swedish research councilSwedish Research Councilen_US
dc.description.sponsorshipErcan Ok is a member of scientific advisory board of Fresenius Medical Care (Turkey). Juan Jesus Carrero acknowledges support from the Loo and Hans Ostermans Foundation and the Swedish research council. The others declare no conflict of interest.en_US
dc.identifier.doi10.2215/CJN.02540311en_US
dc.identifier.endpage2246en_US
dc.identifier.issn1555-9041
dc.identifier.issue9en_US
dc.identifier.pmid21836150en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2240en_US
dc.identifier.urihttps://doi.org/10.2215/CJN.02540311
dc.identifier.urihttps://hdl.handle.net/11454/46089
dc.identifier.volume6en_US
dc.identifier.wosWOS:000294654200020en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Soc Nephrologyen_US
dc.relation.ispartofClinical Journal of the American Society of Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAssociations of Triiodothyronine Levels with Carotid Atherosclerosis and Arterial Stiffness in Hemodialysis Patientsen_US
dc.typeArticleen_US

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