The Association of Minor Congenital Anomalies and Childhood Cancer

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dc.contributor.authorDurmaz, Asude
dc.contributor.authorDurmaz, Burak
dc.contributor.authorKadioglu, Bengu
dc.contributor.authorAksoylar, Serap
dc.contributor.authorKarapinar, Deniz
dc.contributor.authorKoturoglu, Guldane
dc.contributor.authorOrman, Mehmet N.
dc.contributor.authorÖzkınay, Ferda
dc.contributor.authorCogulu, Ozgur
dc.date.accessioned2019-10-27T21:24:02Z
dc.date.available2019-10-27T21:24:02Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground. Although the association of some congenital malformations and specific genetic syndromes is well understood, the association between minor anomalies and cancer is not well known. In recent years some researchers have reported studies establishing this association in different types of cancer. In this study, we aimed to investigate the prevalence and patterns of age-independent minor anomalies in childhood cancer patients. Procedure. Two hundred patients with various types of cancer and 200 healthy controls were examined by two different medical geneticists for minor anomalies who evaluated all the cases and controls simultaneously. Besides minor anomalies, information on the consanguinity between the parents and occurrence of cancer in relatives were also recorded. The types of minor anomalies in different types of cancer, the number of minor anomalies in patients and controls, the association between cancer and the occurrence of different types of minor anomalies were also evaluated. Results. The consanguinity and the history of cancer in relatives were significantly more prevalent in patients (P = 0.04 and P < 0.001, respectively). The number of minor anomalies in patients were significantly higher compared to the controls (P < 0.01). Particularly, the presence of hypertelorism, high-arched palate (approximately 40-fold higher, 95% CI: 12.895-125.037) and hand-foot anomalies were found to be more prevalent in patients having cancer compared to the controls. Conclusion. The common pathways during the embryogenesis may play a role in the development of cancer. The presence and the combination of minor anomalies seem to be associated with a higher prevalence of cancer. Pediatr Blood Cancer 2011;56:1098-1102. (C) 2011 Wiley-Liss, Inc.en_US
dc.identifier.doi10.1002/pbc.23049en_US
dc.identifier.endpage1102en_US
dc.identifier.issn1545-5009
dc.identifier.issn1545-5017
dc.identifier.issue7en_US
dc.identifier.pmid21360657en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1098en_US
dc.identifier.urihttps://doi.org/10.1002/pbc.23049
dc.identifier.urihttps://hdl.handle.net/11454/44322
dc.identifier.volume56en_US
dc.identifier.wosWOS:000289440800017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Blood & Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildhood canceren_US
dc.subjectminor anomaliesen_US
dc.titleThe Association of Minor Congenital Anomalies and Childhood Canceren_US
dc.typeArticleen_US

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