Emergence of phenotypic resistance to ciprofloxacin and levofloxacin in methicillin-resistant and methicillin-sensitive Staphylococcus aureus strains

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dc.contributor.authorLimoncu, MH
dc.contributor.authorErmertcan, S
dc.contributor.authorCetin, CB
dc.contributor.authorCosar, G
dc.contributor.authorDinc, G
dc.date.accessioned2019-10-27T19:00:50Z
dc.date.available2019-10-27T19:00:50Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractThe emergence of phenotypic resistance to ciprofloxacin and levofloxacin in methicillin-sensitive and methicillin-resistant Staphylococcus aureus (MRSA) strains was studied. Twenty MRSA and 77 methicillin-sensitive S.aureus (MSSA) strains susceptible to both quinolones were investigated for resistance after single step or serial passages. No growth of 20 MRSA strains was observed at 4 x MIC of levofloxacin after 48 h incubation, but 4 of 77 (5%) MSSA strains grew at the same concentration. At 4 x MIC concentration of ciprofloxacin, 10 MSSA (13%) and five MRSA (25%) strains were grown. In the serial passages of MRSA strains, resistance to ciprofloxacin was 75 and 5% for levofloxacin by the third passage. In the seventh passage this resistance was 100 and 15%, respectively. In MSSA strains, resistance to ciprofloxacin was 75 and 19% to levofloxacin at the third passage and at the seventh passage, 100 and 61%, respectively. Emergence of ciprofloxacin resistance was more common and developed more rapidly than resistance to levofloxacin in both MRSA and MSSA strains. (C) 2003 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.en_US
dc.identifier.doi10.1016/S0924-8579(03)00006-2en_US
dc.identifier.endpage424en_US
dc.identifier.issn0924-8579
dc.identifier.issue5en_US
dc.identifier.pmid12727074en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage420en_US
dc.identifier.urihttps://doi.org/10.1016/S0924-8579(03)00006-2
dc.identifier.urihttps://hdl.handle.net/11454/37831
dc.identifier.volume21en_US
dc.identifier.wosWOS:000183033400005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal of Antimicrobial Agentsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectphenotypic resistanceen_US
dc.subjectlevofloxacinen_US
dc.subjectciprofloxacinen_US
dc.titleEmergence of phenotypic resistance to ciprofloxacin and levofloxacin in methicillin-resistant and methicillin-sensitive Staphylococcus aureus strainsen_US
dc.typeArticleen_US

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