Chemical Composition and Tyrosinase Inhibitory Activities of Fatty Acids Obtained from Heterotrophic Microalgae, S. limacinum and C. cohnii
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Tyrosinase is the rate-limiting enzyme for melanin production in plant and mammalian cells. Upregulation of this enzyme results in hyperpigmentation disorders. In order to treat pigmentation problems, novel skin whitening compounds are extremely screened. It is found that fatty acids based on their saturation levels either increase or decrease tyrosinase enzyme activity. Thus, fatty acids and their compositions are promising candidates for the treatment of hyperpigmentation or hypopigmentation disorders. Microalgae are rich in both saturated and unsaturated fatty acids, as well. In this study, C. cohnii and S. limacinum fatty acids were evaluated as tyrosinase inhibitor candidates. Mushroom tyrosinase activity studies displayed that both extracts increase tyrosinase enzyme activity dose-dependently. On the other hand, S. limacinum at 200 mu g ml(-1) concentration almost decreased half of tyrosinase enzyme activity in B16-F10 cells. Besides, it was 3 times more efficient for tyrosinase enzyme activity inhibition and 2 times more effective to decrease melanin synthesis compared to C. cohnii. Considering low toxicity to B16-F10 melanoma and healthy keratinocyte cells (HaCaT), S. limacinum fatty acids could be a suitable source for lipid-based tyrosinase inhibitory functional cosmetics products.
Açıklama
Anahtar Kelimeler
Tyrosinase, B16-F10 melanoma cells, Fatty acids, Microalgae, Melanogenesis, Melanin Synthesis, Lipid Production, Linoleic-Acid, Melanogenesis, Antioxidant, Cells, Anticholinesterase, Improvement, Growth, Oil
Kaynak
Applied Biochemistry and Biotechnology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
