Which dosing scheme is suitable for the taxanes? An in vitro model

Basit Öğe Kaydı
dc.contributor.authorSanli, UA
dc.contributor.authorUslu, R
dc.contributor.authorKarabulut, B
dc.contributor.authorSezgin, C
dc.contributor.authorSaydam, G.
dc.contributor.authorOmay, SB
dc.contributor.authorGoker, E
dc.date.accessioned2019-10-27T18:44:01Z
dc.date.available2019-10-27T18:44:01Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractThe discovery and development of the taxane class of antitumor compounds represent significant advances in the treatment of patients with a variety of malignancies. These drugs are effectively used in the treatment of breast cancer. In this study we evaluated the efficacy of fractionated usage of both paclitaxel and docetaxel as a single agent in the breast cancer cell line MCF-7. It has been shown that the cytotoxic effect of paclitaxel was increased when the divided IC50 concentrations were used sequentially and in contrast to paclitaxel, cytotoxic effect of docetaxel was decreased with the same schema and the single dose Of IC50 concentration was optimal. The cause of the difference between the cytotoxic effects of two agents with this schedule is obscure. Demonstrating mechanisms, which are responsible for these differences, will be important for more rational use of taxoids and to provide basis for the following clinical trials.en_US
dc.identifier.doi10.1007/BF02976617en_US
dc.identifier.endpage555en_US
dc.identifier.issn0253-6269
dc.identifier.issue4en_US
dc.identifier.pmid12214871en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage550en_US
dc.identifier.urihttps://doi.org/10.1007/BF02976617
dc.identifier.urihttps://hdl.handle.net/11454/37270
dc.identifier.volume25en_US
dc.identifier.wosWOS:000177881100026en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPharmaceutical Society Koreaen_US
dc.relation.ispartofArchives of Pharmacal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbreast canceren_US
dc.subjectdocetaxelen_US
dc.subjectMCF-7en_US
dc.subjectpaclitaxelen_US
dc.subjectcytotoxicityen_US
dc.titleWhich dosing scheme is suitable for the taxanes? An in vitro modelen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu