Investigation of the effects of 50 Hz magnetic fields on platelet aggregation using a modified aggregometer

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dc.contributor.authorSagdilek, Engin
dc.contributor.authorSebik, Oguz
dc.contributor.authorCelebi, Gurbuz
dc.date.accessioned2019-10-27T21:33:51Z
dc.date.available2019-10-27T21:33:51Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: Electromagnetic fields have various effects on intracellular calcium levels, free oxygen radicals and various enzymes. The platelet activation pathway involves an increase in intracellular calcium levels and protein kinase C activation; and free oxygen radicals play a mediating role in this pathway. This study investigated whether 1 mT and 6 mT, 50 Hz magnetic fields had any effects on platelet aggregation. Materials and Methods: Blood from healthy volunteers was anticoagulated with either citrate or heparin. Each sample was divided in half and assigned to exposure and control groups. Platelet rich plasma samples in the exposure group were exposed to a 1 mT or a 6 mT, 50 Hz magnetic field for 1.5 or 1 h, respectively. The samples from both exposure and control groups were simultaneously evaluated using a modified optical aggregometer. Adenosine-diphosphate, collagen, and epinephrine were used as inducing agents. The slopes of the aggregation curve, the maximum values and the areas under the curves were recorded and compared. Results: A significant effect was observed only in the 1 mT-citrate group. It was found that magnetic field exposure significantly increased the maximum values and slopes of the collagen-induced aggregations. Conclusions: It was found that magnetic field exposure has an activating effect on platelet aggregation.en_US
dc.description.sponsorshipUludag University Scientific Research UnitUludag University [T-2008/47]; Ege University Committee for Scientific Research ProjectsEge University [2008-TIP-013]en_US
dc.description.sponsorshipThis project was supported by Uludag University Scientific Research Unit (Project Number: T-2008/47) and Ege University Committee for Scientific Research Projects (Project Number: 2008-TIP-013).en_US
dc.identifier.doi10.3109/15368378.2012.681822en_US
dc.identifier.endpage393en_US
dc.identifier.issn1536-8378
dc.identifier.issue4en_US
dc.identifier.pmid22690688en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage382en_US
dc.identifier.urihttps://doi.org/10.3109/15368378.2012.681822
dc.identifier.urihttps://hdl.handle.net/11454/45442
dc.identifier.volume31en_US
dc.identifier.wosWOS:000310808500014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofElectromagnetic Biology and Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectromagnetic Fieldsen_US
dc.subjectPlatelet Aggregationen_US
dc.subjectOptical Aggregometeren_US
dc.titleInvestigation of the effects of 50 Hz magnetic fields on platelet aggregation using a modified aggregometeren_US
dc.typeArticleen_US

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