Might there be a link between mannose binding lectin and vitiligo?

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dc.contributor.authorOnay, Huseyin
dc.contributor.authorPehlivan, Mustafa
dc.contributor.authorAlper, Sibel
dc.contributor.authorÖzkınay, Ferda
dc.contributor.authorPehlivan, Sacide
dc.date.accessioned2019-10-27T19:35:51Z
dc.date.available2019-10-27T19:35:51Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractMannose binding lectin (MBL) is a calcium dependent lectin that causes predisposition to infections and autoimmune diseases. This study aimed to examine the presence of any association between MBL2 gene variants and vitiligo. Codon 54 (allele B) and codon 57(allele C) polymorphisms in the exon 1 of the MBL2 gene were investigated in samples belonged to 50 healthy controls and 40 patients diagnosed as vitiligo. The PCRRFLP method was used to investigate the polymorphisms in the MBL2 gene. Codon 57 polymorphism was not detected in any of the subjects from either group. The frequencies of low level MBL2 genotypes for codon 54 (AB and 1313) polymorphisms were found to be significantly higher in the patient group compared to controls (37.5% vs. 6%) (p < 0.001). B allele frequency was also significantly higher in the patient group (20%) compared to the control group (3%). These results suggested that codon 54 polymorphism in the MBL2 gene may play a role in susceptibility to vitiligo.en_US
dc.identifier.doi10.1684/ejd.2007.0128en_US
dc.identifier.endpage148en_US
dc.identifier.issn1167-1122
dc.identifier.issue2en_US
dc.identifier.pmid17337399en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage146en_US
dc.identifier.urihttps://doi.org/10.1684/ejd.2007.0128
dc.identifier.urihttps://hdl.handle.net/11454/39784
dc.identifier.volume17en_US
dc.identifier.wosWOS:000245824000007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohn Libbey Eurotext Ltden_US
dc.relation.ispartofEuropean Journal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMBLen_US
dc.subjectvitiligoen_US
dc.subjectsusceptibilityen_US
dc.subjectpolymorphismen_US
dc.titleMight there be a link between mannose binding lectin and vitiligo?en_US
dc.typeArticleen_US

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