Embryonic microenvironment suppresses YY1 and YY1-related genes in prostate cancer stem cells

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dc.authoridTaskiran, Aysegul/0000-0001-9780-6948
dc.contributor.authorTaskiran, Aysegul
dc.contributor.authorOktem, Gulperi
dc.contributor.authorDemir, Aleyna
dc.contributor.authorOltulu, Fatih
dc.contributor.authorOzcinar, Emine
dc.contributor.authorDuzagac, Fahriye
dc.contributor.authorGuven, Ummu
dc.date.accessioned2024-08-31T07:50:44Z
dc.date.available2024-08-31T07:50:44Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractYin yang 1 (YY1), a transcription factor, plays crucial roles in cell fate specification, differentiation, and pluripotency during embryonic development. It is also involved in tumorigenesis, drug resistance, metastasis, and relapse caused by cancer stem cells (CSCs), particularly in prostate cancer (PCa). Targeting YY1 could potentially eliminate prostate CSCs (PCSCs) and provide novel therapeutic approaches. PCa tissues often exhibit elevated YY1 expression levels, especially in high-grade cases. Notably, high-grade PCa tissues from 58 PCa patients and CD133high/CD44high high /CD44 high PCSCs isolated from DU145 PCa cell line by FACS both showed significantly increased YY1 expression as observed through immunofluorescence staining, respectively. To investigate the embryonic microenvironment impact on YY1 expression in CSC populations, firstly PCSCs were microinjected into the inner cell mass of blastocysts and then PCSCs were co-cultured with blastocysts. Next Generation Sequencing was used to analyze alterations in YY1 and related gene expressions. Interestingly, exposure to the embryonic microenvironment significantly reduced the expressions of YY1, YY2, and other relevant genes in PCSCs. These findings emphasize the tumor-suppressing effects of the embryonic environment by downregulating YY1 and YY1-related genes in PCSCs, thus providing promising strategies for PCa therapy. Through elucidating the mechanisms involved in embryonic reprogramming and its effects on YY1 expression, this research offers opportunities for further investigation into focused therapies directed against PCSCs, therefore enhancing the outcomes of PCa therapy. As a result, PCa tumors may benefit from YY1 and associated genes as a novel therapeutic target.en_US
dc.identifier.doi10.1016/j.prp.2024.155467
dc.identifier.issn0344-0338
dc.identifier.issn1618-0631
dc.identifier.pmid39047662en_US
dc.identifier.scopus2-s2.0-85199310983en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.prp.2024.155467
dc.identifier.urihttps://hdl.handle.net/11454/105335
dc.identifier.volume260en_US
dc.identifier.wosWOS:001280630200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofPathology Research and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectYin Yang 1en_US
dc.subjectProstate Canceren_US
dc.subjectCancer Stem Cellen_US
dc.subjectEmbryonic Microenvironmenten_US
dc.subjectReprogrammingen_US
dc.titleEmbryonic microenvironment suppresses YY1 and YY1-related genes in prostate cancer stem cellsen_US
dc.typeArticleen_US

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