Comparison of Continuous-Flow and Pulsatile-Flow Blood Pumps on Reducing Pulmonary Artery Pressure in Patients With Fixed Pulmonary Hypertension

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dc.contributor.authorOzturk, Pelin
dc.contributor.authorEngin, Aysen Yaprak
dc.contributor.authorNalbantgil, Sanem
dc.contributor.authorOguz, Emrah
dc.contributor.authorAyik, Fatih
dc.contributor.authorEngin, Cagatay
dc.contributor.authorYagdi, Tahir
dc.contributor.authorErkul, Sinan
dc.contributor.authorBalcioglu, Ozlem
dc.contributor.authorOzbaran, Mustafa
dc.date.accessioned2019-10-27T22:08:29Z
dc.date.available2019-10-27T22:08:29Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractPulmonary hypertension (PH) is considered as a risk factor for morbidity and mortality in patients undergoing heart transplantation. Recently, left ventricular assist device (LVAD) implantation has been increasingly used in reducing pulmonary artery pressure (PAP) in patients with PH unresponsive to medical therapy. Herein, we aimed to compare the efficacy of continuous-flow and pulsatile-flow blood pumps on the improvement of PH in mechanical circulatory support patients. Twenty-seven patients with end-stage heart failure who underwent LVAD implantation surgery were enrolled. Fifteen of them (55.6%) had continuous-flow pump (HeartWare Ventricular Assist System, HeartWare, Inc., Miramar, FL, USA), and 12 of them (44.4%) had pulsatile pump (Berlin Heart EXCOR ventricular assist device, Berlin Heart AG, Berlin, Germany). The efficacy of LVADs on the improvement of PH was compared between continuous-flow and pulsatile pumps by the evaluation of systolic PAP, tricuspid annular plane systolic excursion (TAPSE), right ventricular systolic motion (RVSM), right ventricular ejection fraction (RVEF), and grade of tricuspid insufficiency (TI) for each of the study participants. All of the 15 patients who underwent continuous-flow blood pump implantation surgery (Group 1) were male with a mean age of 46.9 +/- 11.7 years, and in pulsatile-flow blood pump implanted participants (Group 2), the mean age was 40.6 +/- 16.8 years, all of whom were also male (P=0.259). Mean follow-up was 313.7 +/- 241.3 days in Group 1 and 448.7 +/- 120.7 days in Group 2 (P=0.139). In Group 1, mean preoperative and postoperative systolic PAP were measured as 51.7 +/- 12.2mmHg and 22.2 +/- 3.4mmHg, respectively, while those in Group 2 were 54.5 +/- 7.5mmHg and 33.9 +/- 6.4mmHg, respectively. A significantly greater decrease in systolic PAP was noticed in patients with continuous-flow blood pumps (P=0.023); however, no statistically significant difference was found when we considered the change in TAPSE between study groups (P=0.112). A statistical significance in the alteration of RVEF, RVSM, and the grade of TI during study visits was not found between the study groups (P=0.472, P=0.887, and P=0.237, respectively). Although the two studied types of LVADs were found to be effective in reducing PAP in heart transplantation candidates with PH, lesser postoperative systolic PAP values were achieved in patients who underwent continuous-flow pump implantation surgery.en_US
dc.identifier.doi10.1111/aor.12164en_US
dc.identifier.endpage767en_US
dc.identifier.issn0160-564X
dc.identifier.issn1525-1594
dc.identifier.issue9en_US
dc.identifier.pmid24033601en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage763en_US
dc.identifier.urihttps://doi.org/10.1111/aor.12164
dc.identifier.urihttps://hdl.handle.net/11454/49188
dc.identifier.volume37en_US
dc.identifier.wosWOS:000325082500005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofArtificial Organsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPulmonary hypertensionen_US
dc.subjectLeft ventricular assist deviceen_US
dc.subjectPulmonary artery pressureen_US
dc.subjectHeart failureen_US
dc.titleComparison of Continuous-Flow and Pulsatile-Flow Blood Pumps on Reducing Pulmonary Artery Pressure in Patients With Fixed Pulmonary Hypertensionen_US
dc.typeArticleen_US

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