Varicella rates among unvaccinated and one-dose vaccinated healthy children in Izmir, Turkey

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dc.contributor.authorKurugol, Zafer
dc.contributor.authorHalicioglu, Oya
dc.contributor.authorKoc, Feyza
dc.contributor.authorKoturoglu, Guldane
dc.contributor.authorAksit, Sadik
dc.date.accessioned2019-10-27T21:38:00Z
dc.date.available2019-10-27T21:38:00Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: We aimed to determine the rate of breakthrough varicella in Turkey, a country with low varicella vaccination coverage. Methods: This study was conducted between April 2008 and March 2009 at the Well-Child Clinic at Ege University and pediatricians' offices. We collected information on vaccination status and varicella infection using a questionnaire. In order to elicit more details about the severity of illness, we interviewed all parents and reviewed the clinician records. Vaccination status was verified from the medical records or vaccination cards with dates. Results: A total of 2802 children were evaluated. Of these, 1683 had been vaccinated with a single dose of varicella vaccine and 1119 were unvaccinated. Among vaccinated children, 466 (27.7%) had breakthrough varicella. Vaccinated children tended to have mild varicella. However, about 25% of breakthrough cases had moderate or severe disease. Children who were vaccinated >= 5 years previously had a 3.7-fold higher risk of breakthrough disease than those who were vaccinated <5 years before. Vaccination at younger than 15 months of age was not significantly associated with an increased risk of breakthrough infection. Conclusions: Breakthrough varicella is not rare in Turkey where varicella infections are common. A longer interval since vaccination may be a risk factor for developing breakthrough varicella. Children who had been vaccinated >5 years previously were at risk for breakthrough disease. A two-dose varicella vaccine policy may be needed to provide improved protection. (C) 2011 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijid.2011.03.016en_US
dc.identifier.endpageE480en_US
dc.identifier.issn1201-9712
dc.identifier.issn1878-3511
dc.identifier.issue7en_US
dc.identifier.pmid21592838en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE475en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2011.03.016
dc.identifier.urihttps://hdl.handle.net/11454/46299
dc.identifier.volume15en_US
dc.identifier.wosWOS:000291794100007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofInternational Journal of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVaricellaen_US
dc.subjectVaricella vaccineen_US
dc.subjectBreakthrough varicellaen_US
dc.subjectRisk factorsen_US
dc.titleVaricella rates among unvaccinated and one-dose vaccinated healthy children in Izmir, Turkeyen_US
dc.typeArticleen_US

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