Infliximab in experimental alkali burns of the oesophagus in the rat

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dc.contributor.authorYukselen V.
dc.contributor.authorVardar E.
dc.contributor.authorYukselen O.
dc.contributor.authorOruc N.
dc.contributor.authorYenisey C.
dc.contributor.authorKaraoglu A.
dc.contributor.authorOzutemiz O.
dc.date.accessioned2019-10-26T23:58:44Z
dc.date.available2019-10-26T23:58:44Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractBackgrounds : We aimed to investigate the efficacy of infliximab, a chimeric TNF-? antibody, in the prevention of fibrosis in an experimental alkaline burn of the oesophagus in the rat. Methods : Thirty-two Wistar albino rats divided into four experimental groups. Caustic oesophageal burn was induced by applying 37.5% NaOH to the distal oesophagus. Infliximab was given at a dose of 5 mg/kg via the intraperitoneal route. Group A (sham) animals were uninjured, group B had untreated oesophageal burns, group C had oesophageal burns treated with a single dose of infliximab on the first day, and Group D had oesophageal burns treated with infliximab on the first and 14th days. Efficacy of the treatment was assessed on the 28th-day by measuring stenosis index of the oesophagus and histopathological damage score, and biochemically by determining tissue hydroxyproline content. Results ; There was no significant difference between the Group B and the infliximab treated Groups C and D in means of tissue hydroxyproline content and histopathological damage scores. Stenosis index was not significantly different between the Group B, Group C, and Group D. Conclusion : Anti-TNF-? treatment with infliximab does not ameliorate the degree of fibrosis in alkali burns of the oesophagus in the rat. Further evaluation of inflammatory and immunological events leading to stricture in alkaline oesophageal burns may provide new perspectives for the treatment of alkaline oesophageal burns.en_US
dc.identifier.endpage26en_US
dc.identifier.issn0001-5644
dc.identifier.issue1en_US
dc.identifier.pmid18396745en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://hdl.handle.net/11454/21274
dc.identifier.volume71en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofActa Gastro-Enterologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaustic injuryen_US
dc.subjectCorrosive oesophagitisen_US
dc.subjectFibrosisen_US
dc.subjectInfliximaben_US
dc.subjectOesophageal burnen_US
dc.subjectStrictureen_US
dc.titleInfliximab in experimental alkali burns of the oesophagus in the raten_US
dc.typeArticleen_US

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