Effect of verapamil on intimal thickening and vascular reactivity in the collared carotid artery of the rabbit
Küçük Resim Yok
Tarih
1996
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Stockton Press
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
1 Intimal thickening is a common site for atherosclerosis. Therefore, we investigated whether the calcium entry blocker verapamil (10 mg kg(-1) body weight day(-1), s.c.) can retard intimal thickening and changes in vascular reactivity induced by a non-occlusive, silicone collar positioned around the left carotid artery of rabbits. The contralateral carotid artery was sham-operated and served as a control. 2 Verapamil and placebo (saline 0.1 ml kg(-1) day(-1), s.c.) treatments were initiated 7 days before placing the collar and lasted 3 weeks. Thereafter, segments were cut from collared and sham-treated arteries for histology and isometric tension recording. 3 The intima/media (I/M) ratio increased after 14 days of collar treatment, but intimal thickening was not inhibited by verapamil (I/M ratio placebo 0.31+/-0.07, verapamil 0.32+/-0.09). 4 The collar decreased the capacity to develop force, as indicated by the response to a supramaximal concentration of KCl, decreased the sensitivity (pD(2)) to acetylcholine (ACh) and phenylephrine (Phe), but increased the sensitivity to 5-hydroxytryptamine (5-HT). 5 Although verapamil did not affect intimal thickening, it normalized the hypersensitivity to 5-HT in collared arteries. 6 The contraction to the supramaximal concentration of KCl was not affected by verapamil. Verapamil decreased the E(max) of ACh, but this was only seen in collar-treated arteries. Verapamil also decreased the sensitivity to ACh and Phe, in both sham- and collar-treated arteries. 7 We conclude that verapamil, without preventing thickening of the intima, can modify collar-induced changes in vascular reactivity.
Açıklama
Anahtar Kelimeler
atherosclerosis, intima, collar, endothelium, 5-hydroxytryptamine, acetylcholine, phenylephrine, verapamil, vascular reactivity, calcium antagonist
Kaynak
British Journal of Pharmacology
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
118
Sayı
7
