Effects of ozone treatment to the levels of neurodegeneration biomarkers after rotenone induced rat model of Parkinson's disease
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The study investigated the effects of ozone treatment on the neurodegeneration of stereotaxic rotenone-induced parkinson's disease (PD) model. The model was confirmed using the apomorphine rotation test. ?-synuclein, amyloid-?, Tau, phosphorylated Tau, as well as tyrosine hydroxylase(+), nNOS(+), and glial cell counts were used to evaluate neurodegeneration in the substantia nigra pars compacta and ventral tegmental area. The experiment involved 48 Sprague-Dawley rats divided into four groups: dimethyl sulfoxide (DMSO), DMSO with ozone (O), DMSO/rotenone (R), and D/R/O. Ozone treatment significantly improved tissue ?-synuclein level and TH+, nNOS+, and glial cell counts compared to the rotenone-only group. The study suggests that ozone treatment may have beneficial effects on PD biomarkers in the rotenone model. Further studies on ozone dosage, duration, and administration methods in humans could provide more evidence for its potential use in Parkinson's disease treatment. © 2023 Elsevier B.V.
Açıklama
Anahtar Kelimeler
Neurodegenerative disease, Ozone, Parkinson's disease, Rotenone, alpha synuclein, amyloid beta protein, amyloid beta protein[1-42], biological marker, dimethyl sulfoxide, ketamine, ozone, rotenone, tau protein, tyrosine, xylazine, animal cell, animal experiment, animal model, apomorphine test, Article, biochemistry, cell count, controlled study, gene expression, glia cell, immunohistochemistry, male, nerve degeneration, nonhuman, Parkinson disease, protein phosphorylation, rat, Sprague Dawley rat, stereotactic treatment, substantia nigra pars compacta, ventral tegmentum
Kaynak
Neuroscience Letters
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
814
