Effect of essential oils and isolated compounds from Pimpinella species on NF-?B: A target for antiinflammatory therapy
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Pimpinella essential oils and isolated compounds were screened for their inhibitory activity against NF-?B mediated transcription in SW1353 cells. Twelve oils were effective in inhibiting NF-?B mediated transcription. Especially the roots of P. corymbosa, P. tragium and P. rhodanta showed potent activities with IC50 values of 2, 3 and 6 µg/mL, respectively. Five pure compounds, 7 (4-(2-propenyl)phenylangelate), 12 (4-(3-methyloxiranyl) phenyltiglate), 17 (4-methoxy-2-(3-methyloxiranyl)phenyl isobutyrate), 18 (4-methoxy-2-(3-methyloxiranyl)phenylangelate) and 21 (epoxy pseudoisoeugenol-2-methylbutyrate) inhibited NF-?B mediated transcription with IC50 values of 5.5, 1.2, 0.01, 3.6 and 11 µg/mL, respectively. None of the compounds were cytotoxic to mammalian cells. These findings add significant information to the pharmacological activity of Pimpinella species and their beneficial effects and use in disease prevention especially those related to inflammation. Copyright © 2007 John Wiley & Sons, Ltd.
Açıklama
Anahtar Kelimeler
Essential oil, NF-?B mediated transcription, Phenylpropanoid, Pimpinella species
Kaynak
Phytotherapy Research
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
21
Sayı
8
