Sepsis-induced changes in behavioral stereotypy in rats; Involvement of tumor necrosis factor-alpha, oxidative stress, and dopamine turnover

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dc.contributor.authorErbaş O.
dc.contributor.authorTaşkiran D.
dc.date.accessioned2019-10-27T08:22:02Z
dc.date.available2019-10-27T08:22:02Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Sepsis-associated encephalopathy (SAE) is defined as a diffuse or multifocal cerebral dysfunction that generally occurs early during severe sepsis. The complete pathophysiology of SAE is unknown, but several mechanisms including endotoxins, inflammatory mediators, the alteration of amino acids and of neurotransmitters, apoptosis, oxidative stress, and blood-brain barrier dysfunction have been suggested. The aim of the present study was to explore the relationship between behavioral stereotypy and plasma levels of tumor necrosis factor-alpha (TNF-?) and malondialdehyde (a marker of lipid peroxidation), and brain homovanillic acid content (a marker of dopamine turnover) in a surgically induced sepsis model in rats. Materials and methods Twenty-two adult male Sprague Dawley rats were included in the study. The cecal ligation and puncture procedure was performed to induce sepsis model. Apomorphine-induced stereotypy test was achieved 24 h after cecal ligation and puncture surgery and then, blood and brain samples were collected for biochemical measurements. Results Significantly higher stereotypy score was found in sepsis group than in the sham group (P = 0.008). Furthermore, septic rats revealed significantly higher plasma TNF-? (P = 0.002) and malondialdehyde levels (P = 0.002), and brain homovanillic acid (P = 0.004) compared with sham rats. There was a significant and positive correlation between the behavioral and biochemical parameters. Conclusions Taken together, these results demonstrate the association between inflammatory response, oxidative stress, and stereotypic behavior in an experimental sepsis model. More comprehensive experimental and clinical studies are required to clarify the specific mechanisms underlying SAE. © 2014 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2013.08.001en_US
dc.identifier.endpage268en_US
dc.identifier.issn0022-4804
dc.identifier.issue1en_US
dc.identifier.pmid24007816en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage262en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2013.08.001
dc.identifier.urihttps://hdl.handle.net/11454/26167
dc.identifier.volume186en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthomovanillic aciden_US
dc.subjectoxidative stressen_US
dc.subjectSepsisen_US
dc.subjectsepsis-associated encephalopathyen_US
dc.subjectstereotypyen_US
dc.subjectTNF-?en_US
dc.titleSepsis-induced changes in behavioral stereotypy in rats; Involvement of tumor necrosis factor-alpha, oxidative stress, and dopamine turnoveren_US
dc.typeArticleen_US

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