Catalase/superoxide dismutase (SOD) and catalase/paraoxonase (PON) ratios may implicate poor glycemic control

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dc.contributor.authorSozmen, EY
dc.contributor.authorSozmen, B
dc.contributor.authorDelen, Y
dc.contributor.authorOnat, T
dc.date.accessioned2019-10-27T18:19:52Z
dc.date.available2019-10-27T18:19:52Z
dc.date.issued2001
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground. Previous studies suggest that elevated oxidative stress implicates poor glycemic control resulting in the development of diabetic complications. By evaluating the relationship between paraoxonase (PON) and antioxidant enzyme activities and glycemic control in diabetic patients with and without complications, we investigated whether there is a role of PON and/or antioxidant status in glycemic control. Methods. A total of 107 patients with type 2 diabetes mellitus (DM) was included in the study. Seventy-five patients had complications including microangiopathy, proliferative retinopathy, and/or nephropathy while 32 had no complications. The control group consisted of 29 age- and sex-matched healthy persons. Serum superoxide dismutase (SOD) and catalase activities were measured according to Sun and Goth, respectively. Basal and salt-stimulated paraoxonase activities and arylesterase activity were determined using the method of Eckerson et al. Results. There was an increase in the catalase activity and a decrease in the basal and salt-stimulated PON activity of patients when compared with controls, while no significant difference was observed in SOD activity. PON phenotypes had no effect on any parameter in patient and control groups. The ratio of catalase/SOD was 2.44 +/- 7.10 and 0.17 +/- 0.09 in diabetics and controls, respectively (p = 0.004); this was associated with an elevation in HbA1c levels. On the other hand, catalase/PON ratio was also enhanced in diabetic patients (2.8 +/- 5.2), showing a relationship with HbA1c levels compared to controls (0.29 +/- 0.3, p = 0.000). Conclusions. The data of this study reveal that enhanced catalase/SOD acid catalase /PON ratios that are correlated with HbA1c levels are observed in diabetic patients; thus, these ratios may be used as markers of poor glycemic control and as risk factors in the development of diabetic complications. (C) 2001 IMSS. Published by Elsevier Science Inc.en_US
dc.identifier.doi10.1016/S0188-4409(01)00285-5en_US
dc.identifier.endpage287en_US
dc.identifier.issn0188-4409
dc.identifier.issue4en_US
dc.identifier.pmid11440784en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage283en_US
dc.identifier.urihttps://doi.org/10.1016/S0188-4409(01)00285-5
dc.identifier.urihttps://hdl.handle.net/11454/35733
dc.identifier.volume32en_US
dc.identifier.wosWOS:000169749700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofArchives of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttype 2 diabetes mellitusen_US
dc.subjectcatalaseen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectparaoxonaseen_US
dc.titleCatalase/superoxide dismutase (SOD) and catalase/paraoxonase (PON) ratios may implicate poor glycemic controlen_US
dc.typeArticleen_US

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