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Öğe Antibacterial activity of Salvia tomentosa essential oil(Elsevier Science Bv, 2001) Haznedaroglu, MZ; Karabay, NU; Zeybek, UThe essential oil of Salvia tomentosa aerial parts, consisting of 1,8-cincol (17%), beta -caryophyllene (11%), cyclofenchene (10%) and delta -cadinene (6%), was screened for its antimicrobial activity. The essential oil remarkably inhibited the growth of tested Grampositive and Gram-negative bacteria except for Pseudomonas aeruginosa. (C) 2001 Elsevier Science B.V. All rights reserved.Öğe Hypericum triquetrifolium Turra. extract exhibits antiinflammatory activity in the rat(Elsevier Ireland Ltd, 2002) Ozturk, B; Apaydin, S; Goldeli, E; Ince, I; Zeybek, UThe aim of the present study was to explore the probable antiinflammatory effect of Hypericum triquetrifolium Turra. in a rat model of carrageenan induced inflammation. Male Wistar rats were treated intraperitoneally with 0.4% dimethlsulphoxide (DMSO) (as control group) and H. triquetrifolium extract (25, 50, 60 mg/kg), 30 min before 0.1 ml 1% carrageenan injection. Paw volume was measured before and 1, 2, 3, 4, 5 and 6 h after the injection of carrageenan. The results are expressed as the mean+/-s.e. mean and the statistical significance of differences between groups was analyzed by One Way Analysis of Variance (ANOVA). The intraplantar injection of carrageenan caused a time-dependent paw edema in the rat although saline injection caused no swelling. Intraperitoneal administration of H. triquetrifolium extract (25, 50, 60 mg/kg) inhibited paw swelling dose-dependently at 2. 3. 4. 5 and 6 h after carrageenan injection (P < 0.05). We can conclude that H. triquetrifolium extract may exert an antinflammatory effect in rats. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.Öğe Hypericum triquetrifolium Turra. extract exhibits antinociceptive activity in the mouse(Elsevier Sci Ireland Ltd, 1999) Apaydin, S; Zeybek, U; Ince, I; Elgin, G; Karamenderes, C; Ozturk, B; Tuglular, IThe aim of the present study was to investigate the antinociceptive activity of Hypericum triquerifolium Turra. extract. The lyophilized extract was administered to male Swiss mice. Formalin paw test and tail flick tests were used for the evaluation of the antinociceptive activity. Plant extract (10, 25, 50 and 60 mg kg(-1), i.p.) (n = 16-24 for each group) or vehicle (n = 27) was administered 30 min before the subplantar formalin injection. In the tail flick test, mice were examined for latency to withdraw their tails from a noxious thermal stimulus using a tail flick meter (n = 8 for each group). The effects of the extract on sensorimotor performance was also assessed (n = 16-24 for each group). The extract caused a significant dose-related inhibition of the first phase (50, 60 mg kg(-1), i.p.) and second phase (10, 25, 50 and 60 mg kg(-1), i.p.) of formalin induced hindpaw licking. Additionally, the extract administration (50, 60 mg kg(-1), i.p.) increased the tail flick latencies. No significant change was observed in any of the treatment groups in the sensorimotor performance test. The observed antinociceptive activity of the extract may be due to its noradrenaline and serotonin reuptake blocking activity. Moreover, the probable antiinflammatory activity of the extract may play a role in the dose-related inhibition of the second phase of formalin paw test. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.Öğe Isolation and structure elucidation of novel natural products from Turkish lichens(Scientific Technical Research Council Turkey, 2003) Kirmizigul, S; Koz, M; Anil, H; Icli, S; Zeybek, UThree natural products were isolated from three different Turkish lichens. Microbiological investigations were also examined of these lichens. Compound 1 is known as 2-hydroxy-4-methoxy-3,6-dimethyl benzoic acid, and is isolated from Pseudevernia furfuracea for the first time. Compounds 2 and 3 are detected as new compounds and called, 3-acetyl-4-amino-2-chloro-1-(4-hydroxy-2-methoxy-6-methylphenyl carbonyloxy) benzene and 2-(4-methoxyphenyl)-2-(5-oxo-4-phenyl-2,5-dihydro-2-furaniliden) acetic acid; they were isolated from Evernia prunastri and Letharia vulpina, respectively. All these compounds had different skeletons. Their structures were established by chemical methods and spectroscopic techniques using IR, UV, 1D and 2D NMR and EI and (+) FAB-Mass methods.Öğe On the Chemistry of Lichens From Turkey - Structure of Nemetzon, the Pigment of the Apothecia From Haematomma-Nemetzii(Verlag Z Naturforsch, 1994) Huneck, S; Himmelreich, U; Schmidt, J; John, V; Zeybek, UThe lichens Haematomma nemetzii, a Ramalina species, and Tornabena scutellifera from Turkey have been analysed chemically. Nemetzon is a new anthraquinone from the apothecia of Haematomma nemetzii.
