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Öğe The effects of IGF-1 and erythropoietin on apoptosis and telomerase activity in necrotizing enterocolitis model(Springer Nature, 2020) Akisu, M.; Durmaz, B.; Koroglu, O.A.; Unlubay, S.; Yalaz, M.; Akin, H.; Kultursay, N.Background: Apoptosis that occurs after hypoxia/reoxygenation (H/R) has an important role in the pathogenesis of necrotizing enterocolitis (NEC). Telomerase activity, showing the regeneration capacity, may also be important in the recovery process. Therefore, we aimed to investigate the effects of insulin-like growth factor-1 (IGF-1) and erythropoietin (EPO) on apoptosis and telomerase activity in an H/R model. Methods: Young mice were divided into four groups each containing ten Balb/c mice. Group 1 (H/R) were exposed to H/R; group 2 and group 3 were pretreated with IGF-1 and EPO, respectively, for 7 days before H/R. Group 4 served as control. Intestinal injury was evaluated by histological scoring and assessment of apoptosis was performed by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) test. Proapoptotic and antiapoptotic gene expressions and telomerase activity were analyzed by real-time PCR. Results: IGF-1- and EPO-treated animals had decreased histological damage and apoptosis, confirmed by TUNEL test and caspase activity. Telomerase activity was increased in these animals in addition to increased expression of antiapoptotic genes. However, proapoptotic gene expressions were not statistically different. Conclusions: The protective effects of IGF-1 and EPO in H/R damage may be through increased expression of antiapoptotic genes and increased telomerase activity, especially for IGF-1. Impact: This is a comprehensive study measuring various variables, namely IGF-1, EPO, apoptosis, apoptotic and antiapoptotic genes, and telomerase activity in the NEC model. The intestinal protective effects of IGF-1 and EPO in H/R damage may occur through increased expression of antiapoptotic genes and increased telomerase activity. To the best of our knowledge, telomerase activity has not been investigated in the NEC model before. Regarding our results, novel strategies may be implemented for the early definitive diagnosis, robust preventive measures, and effective treatment modalities for NEC. © 2020, International Pediatric Research Foundation, Inc.Öğe THE EFFECTS OF INSULIN LIKE GROWTH FACTOR-1 AND ERITHROPOETIN ON APOPTOSIS AND TELOMERASE ACTIVITY IN AN EXPERIMENTAL NECROTIZING ENTEROCOLITIS MODEL(Nature Publishing Group, 2011) Koroglu, O. Altun; Akisu, M.; Unlubay, S.; Yalaz, M.; Baka, M.; Cogulu, O.; Akin, H.; Ates, U.; Kultursay, N.Öğe EVALUATION OF CEREBRAL AND MESENTERIC BLOOD FLOW DURING RETINOPATHY OF PREMATURITY EXAMINATIONS(Springer, 2016) Yasar, B. E.; Terek, D.; Ergin, F.; Koroglu, O. Altun; Yalaz, M.; Akisu, M.; Kultursay, N.Öğe Genetic Factors that Influence Short-term Neurodevelopmental Outcome in Term Hypoxic-Ischaemic Encephalopathic Neonates(Sage Publications Ltd, 2011) Calkavur, S.; Akisu, M.; Olukman, O.; Balim, Z.; Berdeli, A.; Cakmak, B.; Koroglu, O.; Yalaz, M.; Kultursay, N.It is difficult to predict outcome in neonates that experience perinatal hypoxic ischaemia. Morbidity and mortality may be affected by genetic factors that augment inflammatory and coagulative responses. This prospective study analysed the effects of proinflammatory cytokine gene polymorphisms (tumour necrosis factor-alpha [TNFA] 308G>A and interleukin-6 [IL6] 174G>C) and prothrombotic factor gene mutations (prothrombin G20210A, factor V Leiden G1691A and methylenetetrahydrofolate reductase [MTHFR] C677T) on the early neurological prognosis in 40 term hypoxic ischaemic encephalopathic neonates. There were significant relationships for Sarnat and Sarnat staging with electroencephalographic findings, transfontanelle ultrasound (US) results, early neonatal outcome and neurological morbidity. Genetic mutations in the prothrombotic proteins, the TNFA 308G>A polymorphism and the cerebrospinal fluid levels of TNF-alpha protein were not related to clinical stage, electroencephalography, transfontanelle US or neurological status at discharge or at postnatal months 6 and 12. The IL6 174GC genotype demonstrated a protective role, being significantly correlated with normal electroencephalography, transfontanelle US and normal neurological findings at discharge. In conclusion, the IL6 174GC gene polymorphism seems to play a role in determining the risk and/or severity of perinatal cerebral injury.Öğe IMPACT OF PHARMACOLOGICAL PDA TREATMENT ON THE MESENTERIC AND CEREBRAL CIRCULATION(Springer, 2016) Ergin, F.; Sahan, Y.; Terek, D.; Yalaz, M.; Koroglu, O. Altun; Levent, E.; Akisu, M.; Kultursay, N.Öğe Improved neonatal prognosis following restriction in the number of transferred embryos in assisted reproduction - single center yearly comparison from Turkey(I R O G Canada, Inc, 2015) Kultursay, N.; Koroglu, O. A.; Uygur, O.; Terek, D.; Tannverdi, S.; Akisu, M.; Yalaz, M.Purpose: To evaluate the impact of new legislation for assisted reproductive technology (ART) restricting the number of transferred embryos on neonatal prognosis of infants born after infertility treatments. Materials and Methods: Neonatal records of all live born infants in Ege University Maternity Ward were reviewed for 2006 and 2012. Neonatal outcome measures such as birth weight (BW), gestational age (GA), preterm birth (PTB), very low birth weight (VLBW), and neonatal intensive care unit (NICU) admission were evaluated. Results: Compared to 2006 percentage of newborns conceived by medically assisted reproduction (MAR) decreased from 14.6% to 5% in all live births, from 23.8% to 8.2% in NICU patients in 2012. The number of fetuses in the last pregnancy, frequency of intrauterine reductions, spontaneous pregnancy losses, antenatal bleeding, and premature delivery decreased. Percentage of multiples among MAR newborns (31.7% vs. 55.7%), twins from 51.4% to 30.9%, triplets from 4.3% to 0.8% all decreased significantly. Mean BW and gestational age increased resulting in decreased frequency of PTB and VLBW. Consequently Level 3 NICU admission rate significantly decreased from 44.3% to 22%. Conclusion: The new ART legislation in Turkey resulted in decreased rate of multiple births, prematurity and related complications, and NICU admissions in MAR newborns. However the twin rates are still high. Since uncontrolled ovulation stimulation and intrauterine insemination techniques are also associated with multiple births and unfavorable neonatal outcomes, these procedures deserve close monitorization.Öğe Incidence and prognosis of intraabdominal hypertension and abdominal compartment syndrome in children(W B Saunders Co-Elsevier Inc, 2016) Divarci, E.; Karapinar, B.; Yalaz, M.; Ergun, O.; Celik, A.Purpose: Intraabdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are associated with high mortality rates in children (40-60%). However, literature lacks comprehensive series in childhood. In this study, we aimed to determine the incidences of IAH and ACS, to identify high risk disorders for the development of IAH/ACS and to decrease ACS-associated mortality by early diagnosis and timely intervention. Methods: A prospective study was performed between December 2009 and October 2010 in our institution. IAH was defined by a sustained or repeated pathological elevation in IAP >= 12 mmHg without a new organ failure. ACS was identified as a sustained IAP > 15 mmHg with a new organ dysfunction/failure. After recognition of IAH or ACS, patients underwent prompt decompressive interventions as medical or surgical procedures. Results: 150 patients were enrolled to the study (86 M, 64 F). The incidences of IAH and ACS were 9% and 4%, respectively. High risk disorders were trauma, ileus, necrotizing enterocolitis, abdominal wall defects, diaphragmatic hernia and septic shock with massive fluid resuscitation. 14 patients with IAH were treated and mean IAP was decreased from 13.9 +/- 1.9 mmHg to 9.2 +/- 2.1 mmHg (p < 0.001). None of them progressed to ACS. Six patients with ACS underwent decompressive laparotomy. Mean IAP decreased significantly from 20 +/- 3 mmHg to 9 +/- 1.4 mmHg (p = 0.001). Vital signs like mean urine output, abdominal perfusion pressure (APP) and respiratory rate were significantly improved after surgery (p < 0.05). ACS-associated mortality rate was determined as 16%. Conclusions: IAH or ACS was occurred in nearly one tenth of patients admitted to neonatal and pediatric intensive care units. High clinical suspect must be drawn on to recognize and treat these clinical complications more efficiently. Regular and frequent IAP measurement in high risk disorders is essential for early diagnosis. Lower mortality rates can be achieved by early recognition and timely intervention in children. (C) 2016 Elsevier Inc. All rights reserved.Öğe MUCOPOLYSACCHARIDOSIS TYPE VII (SLY DISEASE): TWO DIFFERENT CLINICAL PRESENTATIONS(Springer, 2010) Kalkan, Ucar S.; Koroglu, O.; Yalaz, M.; Kultursay, N.; Coker, M.Öğe The net impact of clinical seizures on outcome characteristics in infants with neonatal encephalopathies at 12 months of age(W.B. Saunders Ltd, 2023) Tekgul, H.; Koroğlu, O.A.; Tanrıverdi, M.; Yalaz, M.; Terek, D.; Aktan, G.; Akisu, M.Purpose: To assess the impact of clinical neonatal seizures on outcome characteristics of preterm and term newborns with neonatal encephalopathy (NE). Methods: We designed a prospective comparative study with 53 babies (preterm neonates: 26 and term neonates: 27) with NE: group 1 (preterm neonates with seizures, n = 13), group 2 (preterm neonates without seizures, n = 13), group 3 (term neonates with seizures, n = 13) and group 4 (term neonates without seizures, n = 14). The functional outcome characteristics of the survivors were assessed by the Ankara Developmental Screening Inventory (ADSI) and the Guide for Monitoring Child Development (GMCD) at 12 months of age. Results: Clinically defined acute symptomatic seizures were diagnosed with prompt conventional EEG / amplitude-integrated EEG in preterm (92.3%) and term neonates (81.4%) with etiology-specific diagnoses of NE. There were no differences between the study groups regarding seizure semiology and EEG characteristics. A primary adverse outcome was defined in 22 (41.5%) of the cohort. However, only 15.3% of infants had an unfavorable functional outcome with ADSI at 12 months. Among the survivors, there was no significant difference between the study groups regarding ADSI scores. The GMDC test revealed normal development in 50% of survivors with seizures in the preterm group and 83% in the term group. Conclusion: There was no significant difference between the characteristics of functional outcomes at 12 months in preterm and term neonates with NE for clinical seizures. © 2022Öğe Polycythaemia in Infants of Diabetic Mothers: beta-Hydroxybutyrate Stimulates Erythropoietic Activity(Field House Publishing Llp, 2011) Cetin, H.; Yalaz, M.; Akisu, M.; Kultursay, N.This study tested whether elevated maternal beta-hydroxybutyrate (beta-OHB) levels contribute to polycythaemia in infants of diabetic mothers. Pregnant diabetic women (n = 27) and non-diabetic controls (n = 20) and their singleton infants were included. Maternal glycosylated haemoglobin and beta-OHB levels were studied at 34 - 36 weeks' gestation; levels were significantly higher in mothers with diabetes than in controls. Birth weights and cord blood levels of insulin and fetal haemoglobin were significantly higher in infants from diabetic mothers compared with control infants, as were haematocrit levels in venous blood samples taken from each infant at 4 h following delivery. Cord blood erythropoietin levels were similar in both groups. There was a positive strong correlation between maternal beta-OHB levels and polycythaemia in newborn infants, indicating that beta-OHB could activate erythropoiesis independently from intrauterine hyperinsulinaemia and/or erythropoietin levels, and may be important in the pathogenesis of polycythaemia in infants born to diabetic mothers.Öğe SINGLE VERSUS MULTIPLE DOSES OF SURFACTANT TREATMENT IN PRETERM INFANTS(Springer, 2016) Bilgin, B. Siyah; Koroglu, O. Altun; Terek, D.; Yalaz, M.; Akisu, M.; Kultursay, N.Öğe SOLUBLE CD14 SUBTYPE (SCD14-ST) PRESEPSIN LEVELS IN PRETERM NEWBORNS WITH RDS(Springer, 2016) Ergor, S.; Koroglu, O. Altun; Yalaz, M.; Akisu, M.; Kultursay, N.
