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Öğe Effect of tube drainage compared with conventional suturing on postoperative discomfort after extraction of impacted mandibular third molars(Churchill Livingstone, 2015) Koyuncu, B. O.; Zeytinoglu, M.; Tetik, A.; Gomel, M. M.The aim of this prospective randomised study was to assess the effects of tube drainage on postoperative discomfort after the extraction of impacted mandibular third molars. We studied 40 patients(11 men and 29 women) 18 years or older (mean(SD) 21(3), range 18-29) who required extraction of mandibular third molars. We used a randomised crossover design by which if a drain was inserted on one side, then the other side was managed with out a drain on a later occasion. Pain, swelling, and mouth opening were evaluated after 48h and 7 days postoperatively in both groups. Facial swelling(p = 0.001), pain p = 0.001), and trismus(p = 0.001) were significantly less common in the drained group compared with those not drained. We conclude that the use a tube drain is of benefit in minimising postoperative swelling, pain, and trismus after extraction of mandibular third molars. (C) 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.Öğe Effects of Perioperative Hypothermia on Extubation, Recovery Time, and Postoperative Shivering in Breast Surgery(Mary Ann Liebert Inc., 2023) Huniler, H.C.; Deniz, M.N.; Günişen, İ.; Yakut, Özdemir, I.; Tetik, A.; Ulukaya, S.Women undergoing breast surgery seem to be under the risk for hypothermia (central body temperature <36°) due to the uncertainty caused by the preoperative preparation time and the variety of operations, leading to neglect of warming precautions. The study examines the perioperative hypothermia (PH) in breast surgery and the relationships between the depth of decrease in body temperature and individual or clinical variables. This prospective, cross-sectional, observational study includes 120 female patients 18-65 years of age who were given general anesthesia for breast surgery. The incidence of hypothermia was 68.1%. The given patients were discriminated as body temperature <36°, hypothermia was significantly related with lower weight, body mass index, American Society of Anesthesiology (ASA) score, baseline body temperatures, higher extubation, and recovery times. When patients' temperature decreases by >1 or 1.5°, lower age and longer durations of operation and anesthesia were also significant variables. The incidence of shivering is quite high at temperatures below 36°C or at 1 and 1.5°C reductions from baseline (72.7%, 84%, 94.1%, respectively). Body temperature changes of the patients had no effect on nausea-vomiting and pain scores. It turned out that the incidence of PH and shivering is high in women who underwent breast surgery. We think that the depth of decrease in body temperature should be taken into account when evaluating the predictors or clinical consequences of hypothermia, except for the 36°C limit for body temperature. Copyright 2023, Mary Ann Liebert, Inc., publishers.Öğe Evaluation of the Brain Cellular Damage during Liver Transplantations(Wolters Kluwer Medknow Publications, 2023) Deniz, M. N.; Sezer, E.; Tetik, A.; Ulukaya, S.Background:Neuroinflammation in patients undergoing major surgery can lead to neuronal damage, and neuronal damage can be detected through the measurement of biochemical markers of brain damage. S100 beta (S100 & beta;), neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP) levels are considered good biomarkers to detect brain damage that emerged with neurotoxicity. Aim:To evaluate neuronal damage during liver transplantations. Materials and Methods:After approval of the ethics committee and patient consents, preoperative and postoperative cognitive functions of 33 patients undergoing liver transplantation were measured using the Mini Mental State Examination (MMSE), whereas simultaneous neuronal damage was evaluated through the measurement of S100 & beta;, NSE, and GFAP levels. Results:There was no statistically significant difference between preoperative and postoperative MMSE. There was a statistically significant decrease in postoperative GFAP (P < 0.05) and a statistically significant increase in NSE (P < 0.05) compared to preoperative values. The decrease in S100 & beta; (P > 0.05) level was statistically insignificant. Conclusions:Neuroprotective approaches in anesthesia protocol protect patients from brain damage during liver transplantation and prevent the development of postoperative cognitive dysfunction. Since the significant increase in NSE levels during liver transplantations was deemed to have been associated with causes other than neuronal damage, NSE should not be evaluated as a marker of brain damage in these operations.Öğe Influence of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms on male infertility in Turkish infertile men with azoospermia and oligozoospermia(Elsevier Science Bv, 2008) Tetik, A.; Aliyeva, U.; Cetintas, V. B.; Semerci, B.; Topcuoglu, N.; Eroglu, Z.Öğe Influence of methylenetetrahydrofolate reductase gene polymorphisms on methotrexate toxicity in patients with rheumatoid arthritis(B M J Publishing Group, 2007) Tetik, A.; Keser, G.; Inal, V.; Aksu, K.; Eroglu, Z.Öğe Optimisation of diagnostic real time PCR assays for ITS-1 and ITS-2 regions of Leishmania Genus(Wiley-Blackwell Publishing, Inc, 2009) Toz, S. Ozensoy; Tetik, A.; Ertabaklar, H.; Zeyrek, F. Yildiz; Culha, G.; Ozbel, Y.Öğe Optimisation of diagnostic real time PCR assays for ITS-1 and ITS-2 regions of Leishmania Genus(Wiley-Blackwell Publishing, Inc, 2009) Toz, S. Ozensoy; Tetik, A.; Ertabaklar, H.; Zeyrek, F. Yildiz; Culha, G.; Ozbel, Y.Öğe The relationship of the methylenetetrahydrofolate reductase C6(77)T gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy(Wiley, 2007) Eroglu, Z.; Erdogan, M.; Tetik, A.; Karadeniz, M.; Cetinalp, S.; Kosova, B.; Sev, C. G. D. Correlated With Hyperhomocysteinemia The; Gunduz, C.; Ozgen, A. G.; Yilmaz, C.Background Poor glycaemic control, hypertension and duration of diabetes are risk factors for the development of diabetic nephropathy, but there may be genetic factors. Recently, a common C to T mutation at nucleotide position 677 of the MTHFR gene (MTHFR677C>T) has been reported to be correlated with hyperhomocysteinemia and the severity of coronary artery disease as macroangiopathy. We aim to investigate Turkish type 2 diabetic patients with/without diabetic nephropathy and healthy group and examine the contribution of the MTHFR gene polymorphism to the development of diabetic nephropathy. Methods DNA was extracted from peripheral leukocytes of the subjects. Genotyping of the MTHFR C677T polymorphism for all individuals was performed by melting curve analysis of the generated amplicons after realtime online PCR. Results This genotype distribution did not differ between control subjects and type 2 diabetic patients in which 6.8% were TT, 43.7% were CT and 49.5% were CC (chi(2) = 0.201, p > 0.05). The frequency of the mutant T allele was 23.4% in diabetic patients with nephropathy versus 33.0% in those without nephropathy. The genotype frequencies were TT, 2.1%; CT, 46.6%; CC, 55.3% in diabetic patients with nephropathy versus TT, 10.7%; CT, 44.6%; CC, 44.6% in those without nephropathy. Conclusions The MTHFR genotype and allele frequencies were not different between diabetic patients with and without nephropathy (chi(2) = 3, 386, p > 0.005; chi(2) = 2.320, p > 0.005, respectively). Therefore, we conclude that the MTHFR gene polymorphism is not associated with the development of diabetic nephropathy in Turkish type 2 diabetic patients. Copyright (D 2007 John Wiley & Sons, Ltd.
