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Öğe Adsorption of I-131 in urine by using anion exchange resin(Springer, 2006) Unak, P.; Teksoz, S.; Medine, E. I.Öğe Design Of A Radiolabeled Polymeric Drug Carrier System (99)mTc(CO)(3)-Oxaliplatin-PEG-PLA(Springer, 2017) Senocak, K.; Teksoz, S.; Kilcar, A. Yurt; Ucar, E.; Aydin, B.Öğe I-131 labeling of tamoxifen and biodistribution studies in rats(Pergamon-Elsevier Science Ltd, 2008) Muftuler, F. Z. Biber; Unak, P.; Teksoz, S.; Acar, C.; Yolcular, S.; Yurekli, Y.Tamoxifen [TAM ([Z]-2-[4-(1,2-diphenyl-1-di-butenyl)-phenoxy]-N,N-dimethylethanamine)] has been used as an antiestrogen drug for treatment and prevention of human breast cancer. Tamoxifen was labeled with I-131 using iodogen as an oxidizing agent. Mass spectroscopy of the cold standard showed that the labeling occurs in ortho position to the phenyl ether position of TAM as expected. Quality control, radiochemical yield and stability were established using the radioelectrophoresis method. The radiolabeled compound maintained its stability throughout working period of 24 h. Scintigraphic imaging was performed and tissue distribution was determined in Albino Wistar rats. According to biodistribution and imaging experiments the radiolabeled compound presented estrogen receptor (ER) specificity and it was uptaken by endometrium as well as breast tissue. (C) 2007 Elsevier Ltd. All rights reserved.Öğe The influence of stereoisomerism on the biological behavior of Tc-99m labeled penicillamine(Springer, 2009) Acar, C.; Teksoz, S.; Unak, P.; Muftuler, F. Z. Biber; Medine, E. I.The aim of this study is to investigate stereoisomeric behavior of penicillamine and the effect of temperature on labeling. In addition, it was explored how stereoisomerism affected biological behavior of them. In the present work, D- and L-enantiomers of penicillamine(D-PA, L-PA) were labeled with Tc-99m using SnCl2 as reducing agent and their radiopharmaceutical potentials were investigated. Quality control procedures were carried out using thin layer radiochromatography (TLRC), electrophoresis and high performance liquid radiochromatography (HPLRC). HPRLC chromatograms showed two peaks for Tc-99m-D-PA, while a single peak was observed for Tc-99m-L-PA at room temperature. However, the single peak was observed at 90 A degrees C for both isomers. Labeling yields of each isomer were found to be over 98%. Biological activity of these complexes was determined on male Albino Wistar rats by biodistribution studies. While the biodistribution result of Tc-99m-D-PA showed high uptake in the liver, maximum uptake of Tc-99m-L-PA was observed in the kidneys. Both two complexes were cleared rapidly from the blood, mainly by the renal system. Since the activity concentration of Tc-99m-D-PA at the 30th minute in the kidneys and the liver reached a maximum value and at the 120th minute, it was removed by renal and hepatobiliary excretion. As a result, it can be concluded that stereoisomerism affect not only the chemical behavior, but also differs their biological behavior of these compounds.Öğe One-step conjugation of glycylglycine with [F-18]FDG and a pilot PET imaging study(Springer, 2018) Senisik, A. M.; Ichedef, C.; Kilcar, A. Y.; Ucar, E.; Ari, K.; Goksoy, D.; Parlak, Y.; Bilgin, Bedriye Elvan Sayit; Teksoz, S.This study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [F-18]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 A degrees C for 30 min in a vial containing AO-GlyGly and [F-18]FDG solution. The radiolabeled product ([F-18]FDG-GlyGly) was obtained with 98.65 +/- 0.35% yield without any purification step which makes this method more attractive for F-18 radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [F-18]FDG tagged GlyGly in vivo.Öğe Radiopharmaceutical model using Tc-99m-MIBI to evaluate amifostine protection against doxorubicin cardiotoxicity in rats(Springer, 2005) Yurekli, Y.; Unak, P.; Ertay, T.; Biber, Z.; Medine, I.; Teksoz, S.Öğe Synthesis And Radiolabeling Of Temozolomide Loaded Solid Lipid Nanoparticles(Springer, 2017) An, K.; Teksoz, S.; Ichedef, C.; Ucar, E.; Kilcar, A. YurtÖğe Tc-99m-glucoheptonate-guanine: Synthesis, biodistribution and imaging in animals(Springer, 2008) Unak, P.; Teksoz, S.; Muftuler, F. Z. Biber; Medine, E. I.; Acar, C.; Yurekli, Y.The aim of the current study was to design a nucleotide-based radiopharmaceutical which could be labeled with Tc-99m and to investigate its radiopharmaceutical efficiency and stability. GHA (glucoheptonate) was used as bifunctional chelate. GHA was labeled with Tc-99m by SnCl2 reduction method first, and then G (guanine) was conjugated with Tc-99m-GHA at 90 C. In order to determine its radiopharmaceutical stability, thin layer radio chromatography (TLRC) and electrophoresis were employed. In addition, the results were confirmed using high performance liquid radio chromatography (HPLRC). Scintigraphic imaging was performed on rats with mammary tumors, while tissue distribution was determined on Albino Wistar rats. Labeling yield was found to be over 95% and the labeled complex maintained its stability during the study period. The lipophilicity of the Tc-99m-GHG was measured and the partition coefficient (logP) of the labeled compound calculated. The results demonstrated that the uptake of Tc-99m-GHG (Tc-99m-glucoheptonate-guanine) reached its maximum at 3 hours p.i. in stomach and intestines. Main way of excretion was renal. Hepatobiliary excretion was also observed. In conclusion, Tc-99m-GHG may be useful as a nucleotide-based radiopharmaceutical for in vivo applications.Öğe Thymidine kinase enzyme selective imaging radiopharmaceutical: Tc-99m(CO)(3)-Ganciclovir(Walter De Gruyter Gmbh, 2013) Gedik, B.; Teksoz, S.; Ichedef, C.; Kilcar, A. Y.; Medine, E. I.; Ucar, E.The aim of this study is to radiolabel ganciclovir, known as having selective antiviral properties against thymidine kinase, with technetium tricarbonylcore (Tc-99m(CO)(3)(+)) and to investigate the biological behavior of this complex in vitro and in vivo. Commercially provided Ganciclovir (GCV) was radiolabeled with Tc-99m(CO)(3)(+). Initially, optimum radiolabeling conditions were determined by analyzing factors such as temperature, pH and time. Quality control of the radiolabeled compound was performed. The radiolabeling yield was found to be 97%. The Tc-99m(CO)(3)-GCV complex also displayed good in vitro stability during the 24 h period. In vitro cell uptake studies showed that the Tc-99m(CO)(3)-GCV complex is highly uptaken in A-549, PC-3, HeLa cell lines according to the control group Tc-99m(I)-tricarbonyl core. The knowledge gained from in vivo and in vitro studies of Tc-99m(CO)(3)-GCV could contribute to the development of a new HSV1-tk gene imaging agent.
