Yazar "Tatli I.I." seçeneğine göre listele

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    Antimicrobial and antimalarial activities of some endemic Turkish Verbascum species
    (2004) Akdemir Z.Ş.; Tatli I.I.; Bedir E.; Khan I.A.
    The antimicrobial activities of ethyl acetate and methanol extracts of five Verbascum species were studied. The dried extracts of the aerial parts of Verbascum chionophyllum Hub.-Mor., V. cilicicum Boiss., V. pterocalycinum var. mutense Hub.-Mor., V. pycnostachyum Boiss. & Helder. and V. splendidum Boiss. were tested in vitro against Candida albicans (ATCC 90028), Cryptococcus neoformans (ATCC 90113), Staphylococcus aureus (ATCC 29213), methicillin-resistant S. aureus (ATCC 43300), Pseudomonas aeruginosa (ATCC 27853), Aspergillus fumigatus (ATCC 90906) and Mycobacterium intracellulare (ATCC 23068) using a 96-well microplate assay. Amphotericin B, ciprofloxacin and rifampin were used as positive controls. The antimalarial activities of the same extracts were also tested to Plasmodium falciparum clone [Sierra Leone D6 (chloroquine-sensitive)]. The antimalarial agents chloroquine and artemisinin were used as positive controls. None of the tested extracts showed important antimicrobial or antimalarial activities.
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    Antioxidant flavonoids from Verbascum salviifolium boiss
    (2004) Akdemir Z.S.; Tatli I.I.; Bedir E.; Khan I.A.
    Phenolic natural products such as flavonoids are known as potential antioxidant compounds. The aim of this study was the isolation, structure elucidation and determination of radical scavenging properties of flavonoids which were guided by DPPH autographic assay from the methanolic extract of the aerial parts of Verbascum salviifolium. From the titled plant, four flavonoid glucosides, apigenin-7-O-ß-glucopyranoside (1), luteolin-7-O-ß- glucopyranoside (2), luteolin-3'-O-ß-glucopyranoside (3), and chrysoeriol-7-O-ß-glucopyranoside (4), were isolated. The structures of the compounds were established on the basis of the spectroscopic evidence. Compounds 1-4 demonstrated scavenging properties toward the 1,1-diphenyl-2- picrylhydrazyl (DPPH) radical in TLC autographic assays.
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    Brine shrimp lethality bioassay of some Verbascum species growing in Turkey
    (2008) Tatli I.I.; Erdogan T.F.; Kahraman C.; Kivcak B.; Akdemir Z.S.
    Verbascum L. (Scrophulariaceae) species are medicinal plants that have been used for the treatment of inflammatory diseases, asthma, spasmodic coughs and other pulmonary problems in Anatolia and in several countries. The objective of this study was to assess the in vivo cytotoxic activities of thirteen Verbascum extracts including V. chionophyllum Hub.-Mor., V. cilicicum Boiss., V. dudleyanum (Hub.-Mor.) Hub.-Mor., V. lasianthum Boiss., V. latisepalum Hub.-Mor., V. mucronatum Lam., V. olympicum Boiss., V. pterocalycinum var. mutense Hub.-Mor., V. pycnostachyum Boiss. & Heldr., V. salviifolium Boiss., V. splendidum Boiss., V. stachydifolium Boiss. & Heldr and V. uschackense (Murb.) Hub.-Mor. using brine shrimp (Artemia salina) lethality bioassay. The methanolic extracts of V. chionophyllum flowers and leaves, V. cilicicum flowers, V. lasianthum flowers, V. mucronatum flowers, V. pycnostachyum flowers and V. splendidum flowers showed the highest inhibitory activities against the brine shrimp. On the other hand, the rest of the species did not show any remarkable cytotoxic activity.
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    Search for antifungal compounds from some Verbascum species growing in Turkey
    (2004) Tatli I.I.; Akdemir Z.Ş.; Bedir E.; Khan I.A.
    Turkish medicinal plants provide a rich source of biologically-active natural products. With the use of simple bioassays, it is possible to evaluate the bioactivity of the natural compounds. Antifungal screening of 16 compounds in a matrix format from two Verbascum species growing in Turkey was conducted directly on thin-layer chromatographic (TLC) plates sprayed with a spore suspension. Compounds possessing strong antifungal activity produced a clear zone of inhibition bounded by a sharp margin regardless of the size of the inhibitory zone. Ilwensisaponin A and C from Verbascum pterocalycinum var. mutense Hub.-Mor. were found to be active. Bioautographic assay indicated that the saponins appeared to be the most effective against Colletotrichum acutatum, C. fragariae and C. gloeosporioides.