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Öğe An anusual multiple myeloma case presenting as laryngeal edema(Wiley-Blackwell, 2016) Tunakan Dalgic, C.; Dusunur Gunsen, F.; Bulut, G.; Ardeniz, F. O.; Gulbahar, O.; Kokuludag, A.; Sin, A. Z.; Mete Gokmen, E. N.Öğe The aspergillus and alternearia skin prick test positivity in Ege university hospital adult allergy clinic(Wiley, 2018) Camyar, A.; Aytac, H.; Ozisik, M.; Bulut, G.; Dalgic, C. T.; Gunsen, F. D.; Ozgul, S.; Sin, A. Z.Öğe Behcet's disease mimicking drug hypersensitivity(Wiley, 2018) Tunakan Dalgic, C.; Dusunur Gunsen, F.; Bulut, G.; Sin, A. Z.Öğe A case of eosinophilic esophagitis with allergic rhinitis(Wiley-Blackwell, 2016) Gunsen, Dusunur F.; Sin, A. Z.; Bor, S.; Sezak, M.; Koc, Peker Z.; Ardeniz, F. O.; Gokmen, Mete E. N.; Gulbahar, O.; Kokuludag, A.Öğe Comparison of different methods in detection of Anti-DsDNA antibodies and their diagnostic utility(Wiley, 2019) Dalgic, Tunakan C.; Gokmen, Mete E. N.; Sin, A. Z.Öğe Comparison of different methods in detection of antimitochondrial antibodies and their diagnostic utility(Wiley, 2019) Dalgic, Tunakan C.; Gokmen, Mete E. N.; Sin, A. Z.Öğe Cutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish population(Mattioli 1885, 2018) Buyukozturk, S.; Kekik, C.; Gokyigit, A. Z.; Filik, F. I. Tezer; Karakaya, G.; Saygi, S.; Dursun, A. B.; Kirbas, S.; Tufekci, A.; Sin, A. Z.; Aydogdu, I.; Sorgun, M. H.; Aydin, N.; Gelincik, A.; Colakoglu, B.; Celik, G.; Oguz, F.Background and objective. Many studies have shown associations between HLAB*15: 02, HLA-A*31: 01 and carbamazepine (CBZ)-induced delayed cutaneous hypersensitivity reactions. The aim of this study is to evaluate a possible association between delayed cutaneous reactions to antiepileptic drugs (AEDs) and certain HLA-A and HLA-B alleles in the Turkish population. Methods. The study consisted of 3 groups: Group I (reactive group) included the patients who had documented delayed cutaneous reactions to any antiepileptic drug. Group II (non-reactive group) included the patients who have been on antiepileptic treatment at least for three months without any adverse reactions. Group III consisted of healthy subjects. The HLA-A and B alleles were analyzed in all groups. Results. Forty patients (29 female) had experienced different hypersensitivity reactions due to AEDs: maculopapular exanthema (26 patients), Stevens-Johnson syndrome (6 patients), drug rash with eosinophilia and systemic symptoms (7 patients), toxic epidermal necrolysis (1 patient). Lamotrigine (11) and CBZ (10) were the most common culprit drugs involved in the reactions. The HLA-B*15: 02 was not present in any of the study groups. However, HLA-B* 35: 02 was found in 4 patients from the reactive group, while it was not observed in non-reactive patients and was detected in only one healthy subject (p = 0.021). Conclusion. Although our preliminary results did not indicate a strong allele association with AED hypersensitivity, HLA-B* 35: 02 appears to be a candidate allele for MPE /DRESS /DIHSS induced by AED's in Turkish population. Further studies with a larger sample size may result in more comprehensive data about the genetic tendency for AED hypersensitivity in the Turkish population.Öğe Depression in hereditary angioedema can cause sexual morbidity(Wiley, 2019) Yatarkalkmaz, S.; Bulut, G.; Ozisik, M.; Sin, A. Z.; Gulbahar, O.; Ozgul, S.; Kuman, O.; Dilek, E.; Gokmen, Mete E. N.Öğe Do skin tests predict next perioperative allergic reaction after perioperative anaphylaxis?(Wiley, 2017) Dalgic, Tunakan C. D.; Gunsen, Dusunur F.; Bulut, G.; Ardeniz, F. O.; Gulbahar, O.; Gokmen, Mete E. N.; Sin, A. Z.; Kokuludag, A.Öğe Factors affecting response and recurrence in omalizumab treatment (Late Breaking Abstract)(Wiley, 2019) Aytac, H.; Camyar, A.; Ozisik, M.; Gokmen, Mete E. N.; Sin, A. Z.Öğe Factors influencing compliance to specific subcutaneous immunotherapy (SCIT)(Wiley, 2017) Bulut, G.; Gunsen, Dusunur F.; Dalgic, Tunakan C; Ardeniz, F. O.; Gulbahar, O.; Kokuludag, A.; Gokmen, Mete N.; Sin, A. Z.Öğe Food Allergy due to Olive(Esmon Publicidad S A, 2009) Unsel, M.; Ardeniz, Oe; Mete, N.; Ersoy, R.; Sin, A. Z.; Gulbahar, O.; Kokuludag, A.We report the case of a 28-year-old man who presented palatal itching and genaralized urticaria following ingestion of olive 3 years after being diagnosed with olive pollinosis. The patient did not have a history of food allergy or urticaria. The results of skin prick tests with aeroallergens including latex were positive for house dust mite and olive pollen. The results of prick tests and prick-to-prick tests for olive fruit were positive, as were those of specific immunoglobulin E tests to olive pollen and fruit. The results of prick tests to peach, pear, kiwi, melon, and nut were negative. Nasal provocation with olive pollen gave positive results. An open oral provocation test with olive oil did not cause symptoms. This case is unique in that the patient developed olive fruit allergy in the presence of olive pollinosis, and he did not experience allergic symptoms to fruits other than olive, thus enabling us to define a new pollen-food (olive-olive) syndrome.Öğe The frequency of venom re-stings in field and protectiveness of venom immunotherapy: real life results(Wiley, 2017) Dalgic, Tunakan C.; Gunsen, Dusunur F.; Bulut, G.; Ardeniz, F. O.; Gulbahar, O.; Gokmen, Mete E. N.; Kokuludag, A.; Sin, A. Z.Öğe HLA-A and HLA-B alleles in Turkish patients with severe anti-epileptic drug allergy(Wiley-Blackwell, 2016) Buyukozturk, S.; Kekik, C.; Aysen, G. Z.; Karakay, G.; Saygi, S.; Tezer-Filik, I. F.; Dursun, B. A.; Kirbas, S.; Tufekci, A.; Sin, A. Z.; Aydogdu, I; Celik, G.; Aydin, N.; Gelincik, A.; Colakoglu, B.; Fatma, O.Öğe The impact of hereditary angioedema on patients' daily life(Wiley-Blackwell, 2013) Gulbahar, O.; Gokmen, N. M.; Erdogan, A. P.; Erdogdu, D.; Koc, Z. P.; Sin, A. Z.; Ardeniz, O.; Gurlek, F.; Buyukozturk, S.; Gelincik, A.; Kokuludag, A.Öğe Misleading allergens in the diagnosis of latex allergy(Wiley, 2017) Gurlek, F.; Unsel, M.; Ardeniz, O.; Koc, Peker Z.; Gulbahar, O.; Sin, A. Z.; Kokuludag, A.; Gokmen, Mete N.Öğe New onset egg allergy in an adult(Esmon Publicidad S A, Dept Allergy & Clin Immunol, Clin Univ Navarra, 2007) Uensel, M.; Sin, A. Z.; Ardeniz, Oe; Erdem, N.; Ersoy, R.; Gulbahar, O.; Mete, N.; Kokuludag, A.We report newly presenting systemic and local allergic reactions to egg in a 55-year-old woman. The patient did not have a history of egg allergy in childhood or occupational exposure to egg proteins; nor did she report any disease that is known to be related to food allergy. A skin prick test with commercial extracts, prick-to-prick test, CAP radioallergosorbent assay, and a double-blind, placebo-controlled food challenge test were used to prove egg allergy. Because egg allergy mainly affects children and symptoms frequently disappear with age, the late onset in this patient is rare.Öğe Prevalence of cypress pollen sensitization and its clinical importance in Izmir, Turkey, with cypress allergy assessed by nasal provocation(Esmon Publicidad S A, 2008) Sin, A. Z.; Ersoy, R.; Gulbahar, O.; Ardeniz, O.; Gokmen, N. M.; Kokuludag, A.Background and objective: Pollens from the Cupressaceae family are considered important allergens in the Mediterranean area, though reports of the prevalence of allergic symptoms have ranged from 1.04% to 35.4%. Our aim was to detect the prevalence of cypress pollen sensitization and determine its clinical importance in patients with seasonal respiratory allergy. Methods: We used skin prick tests (SPT) and serum specific IgE assays to reveal sensitization to cypress pollen. In patients who showed positive results to cypress pollen, a nasal provocation test (NPT) with pollen extract was used to assess the target organ response. Results: Sixty-five (14.3%) of 455 patients showed positive SPT responses to Cupressus sempervirens extract. Only I patient was monosensitized while 64 patients were polysensitized. Among those, 2 pollen cosensitizations were found to be significant (86% were cosensitized to grasses and 72% were cosensitized to olive (P <.001). Serum specific IgE to cypress pollen was measured in 50 of the 65 patients; findings were positive for 37. When these 37 patients underwent NPT with C sempervirens allergen extract, only the single monosensitized patient had a positive NPT. Conclusion: A positive SPT to cypress pollen may not reflect the true prevalence of sensitization. We assume that in the absence of a positive NPT, positive SPT results might be related to the presence of cross-reactivity between pollen species.Öğe A rare food allergy case: anaphylaxis related pomegranate(Wiley-Blackwell, 2016) Gunsen, Dusunur F.; Gokmen, Mete E. N.; Bartolome, B.; Buyuktiryaki, B.; Koc, Peker Z.; Ardeniz, F. O.; Gulbahar, O.; Kokuludag, A.; Sin, A. Z.Öğe Subcutaneous immunotherapy with single or multiple allergens in monosensitised or polysensitised patients: clinical efficacy and the effects on health-related quality of life(Wiley-Blackwell, 2013) Erdogan, A. P.; Sin, A. Z.; Koc, Z. P.; Kose, T.; Gurlek, F.; Ardeniz, O.; Gulbahar, O.; Gokmen, N. M.; Kokuludag, A.
