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Öğe Analysis of genetic mutations in patients with hereditary angioedema (HAE) type I identified one family with novel homozygous mutation indicating rare instance of autosomal recessive inheritance(Blackwell Publishing, 2008) Kesim, B.; Buyukozturk, S.; Gelincik, A.; Eraslan, S.; Uzumcu, A.; Mete, N.; Sin, A.; Ozseker, F.; Erdenen, F.; Colakoglu, B.; Dal, M.; Uyguner, O.Öğe Drug allergy in tertiary care in Turkey: Results of a national survey. The ADAPT study: Adult drug allergy perception in Turkey(Elsevier Doyma Sl, 2014) Celik, G. E.; Karakaya, G.; Ozturk, A. B.; Gelincik, A.; Abadoglu, O.; Sin, A.; Damadoglu, E.; Yilmaz, I.; Demirturk, M.; Dursun, B.; Ozdemir, S. K.; Celikel, S.; Degirmenci, P.; Bozkurt, B.; Goksel, O.; Erkekol, F. O.; Aydin, O.; Kavut, A. B.; Kirmaz, C.; Kalpaklioglu, F.; Buyukozturk, S.; Kalyoncu, F.Background: No data are available on the incidence of drug hypersensitivity (DH) reactions in outpatient settings of tertiary allergy/immunology clinics. Our aims were to document the frequency of outpatient hospital admissions due to DH reactions to allergy/immunology clinics in adults and the management of these reactions in real life. We also investigated whether drug allergy affected social and medical behaviours of the patients. Methods: This multi-centre study was performed for one year with the participation of 11 out of 16 tertiary allergy/clinical immunology clinics in Turkey. The study group consisted of the patients with DH reactions. Results of a questionnaire including drug reactions and management were recorded. Results: Among 54,863 patients, 1000 patients with DH were enrolled with a median of 2.1% of all admissions. In real life conditions, the majority of approaches were performed for finding safe alternatives (65.5%; 1102 out of 1683) with 11.7% positivity. Diagnostic procedures were positive in 27% (154/581) of the patients. The majority of the patients had higher VAS scores for anxiety. A total of 250 subjects (25%) reported that they delayed some medical procedures because of DH. Conclusion: Our results documented the frequency of admissions due to DH reactions to allergy/clinical immunology clinics for the first time. Although physicians mostly preferred to perform drug tests in order to find safe alternatives, considering the fact that DH was confirmed in 27% of the patients, use of diagnostic tests should be encouraged, if no contraindication exists in order to avoid mislabelling patients as DH. (C) 2013 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Genotype has impact on complement proteins in patients with hereditary angioedema(Wiley, 2017) Gokmen, Mete N. M.; Onay, H.; Koc, Peker Z.; Gulbahar, O.; Sin, A.; Buyukozturk, S.; Gelincik, A.Öğe Hereditary angioedema case series(Wiley-Blackwell, 2011) Gokmen, Mete N.; Ardeniz, O.; Sin, A.; Gulbahar, O.; Koc, Peker Z.; Gurlek, F.; Kokuludag, A.Öğe How familiar are doctors in Turkey with hereditary angioedema?(Wiley-Blackwell, 2013) Gokmen, N. M.; Gulbahar, O.; Koc, Z. P.; Ardeniz, O.; Gurlek, F.; Sin, A.; Kokuludag, A.; Gelincik, A.; Buyukozturk, S.Öğe IgE dependent immediate hypersensitivity to monoclonal antibodies: do they occur as frequently as we have expected?(Wiley, 2017) Dalgic, Tunakan C.; Gunsen, Dusunur F.; Bulut, G.; Zihni, Yargucu F.; Turgutkaya, K.; Kokuludag, A.; Sin, A.Öğe The importance of nasal provocation test in the diagnosis of natural rubber latex allergy(Wiley-Blackwell Publishing, Inc, 2009) Uensel, M.; Mete, N.; Ardeniz, Oe; Goeksel, S.; Ersoy, R.; Sin, A.; Gulbahar, O.; Kokuludag, A.Most studies regarding natural rubber latex (NRL) allergy have concentrated on the prevalance using skin prick test (SPT) and specific IgE assay. The objective of this study is to examine the target organ (skin, nasal mucosa) responses in patients with positive SPT to NRL using the nasal provacation test (NPT) and glove use test (GUT). Four thousand four hundred and twenty patients presented to our polyclinic between July 2003 and January 2007 were evaluated. One thousand six hundred and ninety-nine patients had positive SPT to one or more allergens (NRL and other inhaler allergens). Twenty-nine patients with positive SPT to NRL comprised the NRL sensitive group (group 1). Thirty-five randomized patients with positive SPT to an inhaler allergen other than NRL and negative NRL-specific IgE comprised atopic control group (group 2). Thirty healthy individuals who had no allergic diseases and had negative SPT and NRL-specific IgE comprised the healthy control group (group 3). The lowest NRL allergen concentration leading to NPT positiveness was 0.05 mu g/mL. NPT was negative in groups 2 and 3. NPT was found to have a sensitivity of 96%, specificity of 100%, negative predictive value of 98% and positive predictive value of 100%. GUT was found to have a sensitivity of 81%, specificity of 90%, negative predictive value of 75% and positive predictive value of 93%. Nasal provocation test was successfully used for the first time in the diagnosis of NRL allergy. NPT is a more sensitive method as compared to GUT.Öğe No effect of antihypertensive drugs on severity of anaphylaxis and side-effects during venom immunotherapy(Wiley, 2019) Arzt-Gradwohl, L.; Schrautzer, C.; Laipold, K.; Herzog, S. A.; Stoevesandt, J.; Trautmann, A.; Vachova, M.; Hawranek, T.; Lang, R.; Alfaya Arias, T.; Chelminska, M.; Kita, K.; Pravettoni, V; Gawlik, R.; Ruiz-Leon, B.; Antolin-Amerigo, D.; Mauro, M.; Boni, E.; Preziosi, D.; Bonadonna, P.; Ernst, B.; Sin, B. A.; Kendirlinan, R.; Gelincik, A.; Sin, A.; Nittner-Marszalska, M.; Rosiek-Biegus, M.; Quercia, O.; Bozek, A.; Reider, N.; Marchi, F.; Poziomkowska-Gesicka, I; Serrano, P.; Jimenez Blanco, A.; Kosnik, M.; Frelih, N.; Hoetzenecker, W.; Sturm, G.Öğe The role of component resolved diagnosis in hymenoptera venom allergy(Wiley, 2019) Engin, A.; Oktelik, F. B.; Gelincik, A.; Sin, A.; Sin, B. A.; Dursun, B. A.; Beyaz, S.; Gorgulu, B.; Cetin, E.; Deniz, G.Öğe Short-term statin treatment has beneficial effects on cardiac functions and inflammation in chronic heart failure(Oxford Univ Press, 2006) Gurgun, C.; Ildizli, M.; Yavuzgil, O.; Sin, A.; Apaydin, A.; Cinar, C.; Kultursay, H.Öğe What do we know about systemic hymenoptera allergy in Turkey? What happens before the patients reach an allergy clinic?(Wiley-Blackwell, 2011) Gulbahar, O.; Ural, C.; Ersoy, R.; Gurlek, F.; Koc, Z.; Ardeniz, O.; Gokmen, N.; Sin, A.; Kokuludag, A.
