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Öğe Association of arms2 gene rs10490924 and htra1 gene rs11200638 polymorphisms with exudative age-related macular degeneration in western aegean population of turkey(Gazi Eye Foundation, 2021) Hazan F.; Nalçaci S.; Akin H.; Menteş J.; Afrashi F.; Erakgün T.; Itirli G.Purpose: The purpose of the study was to investigate the relation between ARMS2 rs10490924 and HTRA1 rs11200638 polymorphisms, gender and exudative Age-Related Macular Degeneration (AMD) in Western Aegean population of Turkey. Materials and Methods: Diagnosis of exudative AMD was established on the basis of fundus examination, spectral domain optical coherence tomography and fl uorescein angiography. Genomic DNA samples were extracted from 75 patients with exudative AMD and 75 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism method was used to determine genotype frequencies of the rs10490924 and rs11200638 polymorphisms. Results: In the evaluations regardless of gender, thymine risk allele of the rs10490924 was slightly frequent in the exudative AMD group than in controls (p:0.028; OR: 1.291). Women with risk allel for rs10490924 had a higher risk for exudative AMD (p= 0.009, OR= 2.527) than men (p=0.504, OR= 1.233). The disease risk in those with TT genotype was higher in women (p:0.025, OR:5.14) than in men (p= 0.621, OR= 1.54). The risk allele (A) of rs11200638 was signifi cantly associated with the disease in women (p= 0.004, OR= 2.917). Additionally, the frequency of AA genotype was higher in women patients (p= 0.016, OR= 4.53) than in men (p= 0.666, OR= 0.88). Conclusions: To our knowledge, our study is the fi rst one showing that the relation between the rs11200638 and exudative AMD development is more in female gender. We suggest that the relation between rs11200638 polymorphism and this disease be investigated in larger populations. © 2021 Gazi Eye Foundation. All rights reserved.Öğe Evaluation of macular thickness changes after uneventful cataract surgery using optical coherence tomography [Komplikasyonsuz katarakt cerrahisi Sonrası Maküla kalınlığındaki değişimin optik koherens tomografi ile değerlendirilmesi](Gazi Eye Foundation, 2015) Değirmenci C.; Afrashi F.; Öztaş Z.; Nalçaci S.; Menteş J.; Akkin C.Purpose: To investigate macular thickness changes after uneventful cataract surgery performed with phacoemulsification method using optical coherence tomography. Materials and Methods: This prospective study was carried out on 30 eyes of 30 patients (15 men, 15 women, mean age 62.63±7.15 years) who underwent phacoemulsification surgery. A complete ophthalmic examination and OCT were performed to all patients preoperatively and at 1 month, 3 month, and 6 month postoperatively. The obtained data were statistically evaluated. Results: The mean values of preoperative and postoperative best corrected visual acuity were statistically different (p<0.01). The mean values of preoperative and postoperative intraocular pressure were not statistically different (p>0.05). Mean macular thickness and central macular thickness measurements were performed before surgery and postoperatively at month 1,3,6. Preoperative mean macular thickness was not statistically different from postoperative 1 month mean macular thickness (p=0.09). There was no difference in mean macular thickness between OCT measurements preoperative and postoperative at 1 month, while mean macular thickness at 3 month and 6 month were significantly higher than properative values(p=0.006 and 0.007 respectively). Central macular thickness values were not different preoperatively and postoperative at month 1,3, and 6, by OCT examinations. Conclusion: Macular thickness changes were detected after phacoemulsification surgery. To detect pathologic conditions which come from these changes further studies required. © 2015 Gazi Eye Foundation. All Rights Reserved.Öğe Outcomes of pneumatic retinopexy in rhegmatogenous retinal detachment [Yirtikli retina dekolmaninda pnömatik retinopeksi sonuçlari](2012) Nalçaci S.; Kaya E.; Afrashi F.; Erakgün T.; Menteş J.; Akkin C.Purpose: To evaluate the anatomic success rate of pneumatic retinopexy in rhegmatogenous retinal detachment and to determine the factors related to anatomic success. Material and Methods: 35 eyes of 35 phakic patients who had rhegmatogenous retinal detachment and who had been treated with pneumatic retinopexy were analysed retrospectively. In 28 eyes 0.3 cc pure perfluoropropane (C3F8) gas and in 7 eyes 0.3 cc pure sulfur hexafluoride (SF6) gas were injected intravitreally. The rate of anatomic success and complications were analyzed. Data was evaluated statistically with Chi-square and Fisher's exact test. Results: The mean age of patients was 55.97±10.71 (16 -75 year). All of 35 eyes were phakic. The mean number of retinal tears was 1.3 (1-3). All of them were located in the upper quadrant. The mean follow up period was 16.69±17.96 months (1-72 month). After the intravitreal gas injection; cryopexy was performed in 11 eyes and argon laser photocoagulation was performed in 24 eyes as additional treatment. Anatomic success rate was 65.7% following pneumatic retinopexy. 12 eyes needed additional operations such as pars plana vitrectomy or scleral buckling surgery. Anatomic success was obtained in all of the eyes with second surgery. The factors related to anatomic success rate were analyzed. Conclusions: Pneumatic retinopexy is an effective treatment in selected patients with phakic rhegmatogenous retinal detachment.Öğe The retinal nerve fiber layer thickness changes evaluated by optical coherence tomography after phacoemulsification surgery [Optik koherens tomografi ile degerlendirilen retina sinir lifi kali{dotless}nli{dotless}gi{dotless}ni{dotless}n fakoemülsifikasyon cerrahisi Sonrasi Degişimi](Turkish Ophthalmology Society, 2014) Degirmenci C.; Afrashi F.; Nalçaci S.; Yilmaz S.G.Objectives: To evaluate the retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT) before and after cataract surgery. Materials and Methods: In our study, we included 44 eyes of 44 patients who underwent uncomplicated cataract surgery and had no preexisting pathology involving the retina, optic nerve, or cornea. All patients were scanned by OCT for RNFL measurements 1 day before and 1 month after cataract surgery. The grading of cataract was based on the Lens Opacities Classification System III (LOCS III). Results: The mean age of patients was 62.68±9.46 years. The mean best-corrected visual acuity (BCVA) was 0.29±0.12 preoperatively and 0.93±0.12 at postoperative one month. The mean RNFL thickness preoperatively was 89.43±23.0 µ and postoperatively was 106.57±12.5 µ. The difference was statistically significant. The mean image quality preoperatively was 44.53% and postoperatively was 63.51%. The difference was also statistically significant. Conclusion: The presence of cataract may affect the image quality of OCT leading to lower RNFL thickness values than expected. Cataract surgery increases the image quality of OCT and allows accurate RNFL measurements.Öğe Scleral buckling versus primary vitrectomy in the management of retinal detachment associated with mild vitreous hemorrhage [Hafif derecede vitreus hemorajisinin eşlik ettigi retina dekolmani{dotless}ni{dotless}n tedavisinde skleral çökertme ile primer vitrektominin karşi{dotless}laşti{dotless}ri{dotless}lmasi{dotless}](Turkish Ophthalmology Society, 2014) Erakgün T.; Nalçaci S.; Afrashi F.; Menteş J.; Akkin C.Objectives: The aim of this study was to compare the surgical impact of scleral buckling (SB) and pars plana vitrectomy (PPV) on the anatomic results and visual recovery in cases of rhegmatogenous retinal detachment with mild vitreous hemorrhage. Materials and Methods: In this study, we included 78 eyes of 78 phakic patients who underwent primary surgery for rhegmatogenous retinal detachment complicated by mild vitreous hemorrhage (38 eyes by SB,40 eyes by PPV);all patients had been followed for longer than 6 months after surgery. The surgical outcome and the rate of complications were retrospectively compared. Mann-Whitney U-test and chi-square test were used for the statistical analysis. Results: The reattachment rate after the first surgery was 78.9% (30/38) in the SB group and 95% (38/40) in the PPV group. The difference between the groups was statistically significant (p=0.035). Unseen retinal breaks in 4 eyes, malpositioned buckle in 2 eyes and insufficient closure of the break in 2 eyes of SB cases, as well as reopening of the original break in 2 eyes of PPV cases were the causes of failure. Visual improvement in the PPV group was significantly better than in the SB group in the third and sixth postoperative months (p?0.001 and p=0.026, respectively). Peroperative and postoperative complications were as follows: in the SB group-subretinal hemorrhage (5.2%), PVR of grade B or worse (10.5%), macular pucker (7.8%), and postoperative cataract (13%); in the PPV groupiatrogenic breaks (10%), lens damage (5%), PVR of grade B or worse (5%),macular pucker (5%), and postoperative cataract (35%). Conclusion: Even though the high incidence of peroperative complications such as iatrogenic breaks or postoperative complications such as cataract formation was the major drawback, the results indicate that PPV performed to alleviate peripheral vitreoretinal tractions and clear vitreous hemorrhage offers better anatomic and functional results than SB in the management of rhegmatogenous retinal detachment associated with mild vitreous hemorrhage.
