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Öğe Analysis of genetic mutations in patients with hereditary angioedema (HAE) type I identified one family with novel homozygous mutation indicating rare instance of autosomal recessive inheritance(Blackwell Publishing, 2008) Kesim, B.; Buyukozturk, S.; Gelincik, A.; Eraslan, S.; Uzumcu, A.; Mete, N.; Sin, A.; Ozseker, F.; Erdenen, F.; Colakoglu, B.; Dal, M.; Uyguner, O.Öğe Food Allergy due to Olive(Esmon Publicidad S A, 2009) Unsel, M.; Ardeniz, Oe; Mete, N.; Ersoy, R.; Sin, A. Z.; Gulbahar, O.; Kokuludag, A.We report the case of a 28-year-old man who presented palatal itching and genaralized urticaria following ingestion of olive 3 years after being diagnosed with olive pollinosis. The patient did not have a history of food allergy or urticaria. The results of skin prick tests with aeroallergens including latex were positive for house dust mite and olive pollen. The results of prick tests and prick-to-prick tests for olive fruit were positive, as were those of specific immunoglobulin E tests to olive pollen and fruit. The results of prick tests to peach, pear, kiwi, melon, and nut were negative. Nasal provocation with olive pollen gave positive results. An open oral provocation test with olive oil did not cause symptoms. This case is unique in that the patient developed olive fruit allergy in the presence of olive pollinosis, and he did not experience allergic symptoms to fruits other than olive, thus enabling us to define a new pollen-food (olive-olive) syndrome.Öğe The importance of nasal provocation test in the diagnosis of natural rubber latex allergy(Wiley-Blackwell Publishing, Inc, 2009) Uensel, M.; Mete, N.; Ardeniz, Oe; Goeksel, S.; Ersoy, R.; Sin, A.; Gulbahar, O.; Kokuludag, A.Most studies regarding natural rubber latex (NRL) allergy have concentrated on the prevalance using skin prick test (SPT) and specific IgE assay. The objective of this study is to examine the target organ (skin, nasal mucosa) responses in patients with positive SPT to NRL using the nasal provacation test (NPT) and glove use test (GUT). Four thousand four hundred and twenty patients presented to our polyclinic between July 2003 and January 2007 were evaluated. One thousand six hundred and ninety-nine patients had positive SPT to one or more allergens (NRL and other inhaler allergens). Twenty-nine patients with positive SPT to NRL comprised the NRL sensitive group (group 1). Thirty-five randomized patients with positive SPT to an inhaler allergen other than NRL and negative NRL-specific IgE comprised atopic control group (group 2). Thirty healthy individuals who had no allergic diseases and had negative SPT and NRL-specific IgE comprised the healthy control group (group 3). The lowest NRL allergen concentration leading to NPT positiveness was 0.05 mu g/mL. NPT was negative in groups 2 and 3. NPT was found to have a sensitivity of 96%, specificity of 100%, negative predictive value of 98% and positive predictive value of 100%. GUT was found to have a sensitivity of 81%, specificity of 90%, negative predictive value of 75% and positive predictive value of 93%. Nasal provocation test was successfully used for the first time in the diagnosis of NRL allergy. NPT is a more sensitive method as compared to GUT.Öğe New onset egg allergy in an adult(Esmon Publicidad S A, Dept Allergy & Clin Immunol, Clin Univ Navarra, 2007) Uensel, M.; Sin, A. Z.; Ardeniz, Oe; Erdem, N.; Ersoy, R.; Gulbahar, O.; Mete, N.; Kokuludag, A.We report newly presenting systemic and local allergic reactions to egg in a 55-year-old woman. The patient did not have a history of egg allergy in childhood or occupational exposure to egg proteins; nor did she report any disease that is known to be related to food allergy. A skin prick test with commercial extracts, prick-to-prick test, CAP radioallergosorbent assay, and a double-blind, placebo-controlled food challenge test were used to prove egg allergy. Because egg allergy mainly affects children and symptoms frequently disappear with age, the late onset in this patient is rare.Öğe The prevalence of Sjogren's syndrome in adult women(Taylor & Francis As, 2006) Kabasakal, Y.; Kitapcioglu, G.; Turk, T.; Oder, G.; Durusoy, R.; Mete, N.; Egrilmez, S.; Akalin, T.Objectives: The aim of this study was to determine the prevalence of primary Sjogren's syndrome (pSS) according to European criteria (1993) and to the US-European Consensus Group (US-EU) criteria (2002) in adult women in Bornova, Izmir, Turkey. Materials and method: The study was designed as a two-phase cross-sectional survey consisting of a baseline questionnaire and collection of blood samples and clinical examination. In the initial phase, positivity for autoantibodies Ro(SS-A), La(SS-B), rheumatoid factor (RF), and anti-nuclear antibodies (ANA) was determined, and in the clinical phase, clinical examination, salivary and ocular tests were performed. Minor salivary gland biopsy was performed for those who had at least three of these five criteria positive. Results: In our sample the prevalence of SS was 1.56% [95% confidence interval (CI) 0.92-2.66] according to the European criteria and 0.72% (95% CI 0.33-1.57) according to the US-EU criteria. Conclusion: To prevent the loss in diagnosis of pSS, the addition of ANA, RF, and tear break-up time (BUT) tests to US-EU criteria would be appropriate.
