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Öğe Procoagulant Phospholipid Activity, Whole Blood Thromboelastography and Thrombin Generation Assay to Detect Hypercoagulability in Thalassemic Children(Amer Soc Hematology, 2014) Gunes, Burcak Tatli; Turker, Meral; Gozmen, Salih; Oymak, Yesim; Ay, Yilmaz; Ince, Dilek; Ozek, Gulcihan; Karapinar, Tuba Hilkay; Atabay, Berna; Vergin, CananÖğe Thioguanine-Related Chronic Hepatotoxicity in a Child with Acute Myeloid Leukemia: A Case Report and Review(Galenos Yayincilik, 2015) Karapinar, Tuba Hilkay; Oymak, Yesim; Ecevit, Cigdem; Yilmaz, Funda; Karakoyun, Miray; Ay, Yilmaz; Vergin, CananThe association between 6-Thioguanine (6-TG) treatment and drug-induced liver injury has been reported since 1976. Recent reports have suggested that treatment of patients with 6-TG can lead to chronic hepatotoxicity and portal hypertension. Most of the cases reported to have 6-TG related hepatotoxicity had acute lymphoblastic leukemia or inflammatory bowel disease. In this case report, we discussed the diagnosis and approach in an acute myeloid leukemia patient who developed 6-TG related chronic hepatotoxicity.Öğe Thioguanine-Related Chronic Hepatotoxicity in a Child with Acute Myeloid Leukemia: A Case Report and Review(Galenos Yayincilik, 2015) Karapinar, Tuba Hilkay; Oymak, Yesim; Ecevit, Cigdem; Yilmaz, Funda; Karakoyun, Miray; Ay, Yilmaz; Vergin, CananThe association between 6-Thioguanine (6-TG) treatment and drug-induced liver injury has been reported since 1976. Recent reports have suggested that treatment of patients with 6-TG can lead to chronic hepatotoxicity and portal hypertension. Most of the cases reported to have 6-TG related hepatotoxicity had acute lymphoblastic leukemia or inflammatory bowel disease. In this case report, we discussed the diagnosis and approach in an acute myeloid leukemia patient who developed 6-TG related chronic hepatotoxicity.Öğe Thioguanine-Related Chronic Hepatotoxicity in a Child with Acute Myeloid Leukemia: A Case Report and Review(Galenos Yayincilik, 2015) Karapinar, Tuba Hilkay; Oymak, Yesim; Ecevit, Cigdem; Yilmaz, Funda; Karakoyun, Miray; Ay, Yilmaz; Vergin, CananThe association between 6-Thioguanine (6-TG) treatment and drug-induced liver injury has been reported since 1976. Recent reports have suggested that treatment of patients with 6-TG can lead to chronic hepatotoxicity and portal hypertension. Most of the cases reported to have 6-TG related hepatotoxicity had acute lymphoblastic leukemia or inflammatory bowel disease. In this case report, we discussed the diagnosis and approach in an acute myeloid leukemia patient who developed 6-TG related chronic hepatotoxicity.