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Öğe Association between caregivers' coping and children's psychiatric symptoms in the heart transplantation process: A pilot study(Wiley, 2021) Kafali, Helin Yilmaz; Kalyoncu, Tugba; Ozbaran, Burcu; Kalyoncu, Emir; Tuncer, Osman Nuri; Ozturk, Pelin; Ozbaran, MustafaOur aim was to investigate whether there is an association between caregivers' coping and children's psychiatric symptoms and quality of life in adolescent heart transplant (HTx) recipients and HTx candidates with left ventricular assist device (LVAD). Fourteen patients were recruited for this pilot study (HTx (n = 8), LVAD (n = 6)). Schedule for Affective Disorders and Schizophrenia for School Aged Children, Present and Lifetime Version (K-SADS) was administered to detect the psychiatric diagnosis of patients. Children's Depression Inventory (CDI), State-Trait Anxiety Inventory, and Pediatric Quality of Life Inventory (PedsQL) were completed by adolescents; Brief Coping Styles Inventory by their caregivers. Six of the participants had an internalizing disorder. Optimistic coping strategy score was significantly higher in the caregivers of adolescents without an internalizing disorder than caregivers of those with an internalizing disorder (U = 2.500, P = .005). Utilizing Spearman's correlation, caregivers' optimistic approach (rho = -0.736, P = .004), and self-confident approach (rho = -0.634, P = .020) had significant negative correlations with children's CDI scores. Moreover, caregivers' optimistic approach score had a significant positive correlation with children's PedsQL score (rho = 0.563, P = .045). According to our preliminary results, it seems that caregivers' optimistic and self-confident coping strategies may be associated with fewer internalizing symptoms and a better quality of life in adolescents in the HTx process. A future multicentered longitudinal study will be planned to assess the effect of caregivers' coping strategies on the psychological adjustment of these children.Öğe Early Onset Schizophrenia Associated With Obsessive-Compulsive Disorder: Clinical Features and Correlates(Lippincott Williams & Wilkins, 2017) Baytunca, Burak; Kalyoncu, Tugba; Ozel, Ismail; Erermis, Serpil; Kayahan, Bulent; Ongur, DostObjectives Obsessive-compulsive disorder (OCD) is notably a comorbid disorder in patients with schizophrenia. This study aimed to evaluate clinical features and correlates of early onset patients with schizophrenia with OCD. Methods In the present study, we included 10 patients with both schizophrenia and OCD and 19 patients with schizophrenia without OCD. The mean antipsychotic doses the patients needed for treatment are standardized as chlorpromazine equivalent dose. Results The mean antipsychotic doses at first episode were 491 376 mg/d in schizophrenia comorbid OCD group and 290 +/- 209 mg/d in the schizophrenia without OCD group (P = 0.018). This significant difference was also found for the mean doses at the assessment for the study (512.40 +/- 336.22 mg/d in schizophrenia comorbid OCD and 296.05 +/- 147.25 mg/d in patients with schizophrenia without OCD, P = 0.012). There was no statistical difference in the mean scores of Clinical Global Impression and Positive and Negative Syndrome Scale between schizophrenia with and without OCD group, respectively. (Clinical Global Impression: 5 +/- 0.66 vs 4.36 +/- 0.83, P = 0.094; Positive and Negative Syndrome Scale: 67.60 +/- 11.84 vs 69.84 +/- 14.62, P = 0.573). Conclusions Adolescents with schizophrenia and OCD needed more antipsychotic doses for acute exacerbation and the maintenance of reduction of psychosis severity than adolescents with only schizophrenia. We could suggest that OCD comorbidity in schizophrenia is more treatment resistant, although the severity of the schizophrenia was similar between study groups. There was no correlation between OCD and schizophrenia symptoms either.Öğe Psychometric Properties of the Turkish Version of "Inventory of Callous-Unemotional Traits-Youth Form"(Galenos Yayincilik, 2017) Kose, Sezen; Kalyoncu, Tugba; Ozyurt, Berrin Eylen; Ozbaran, BurcuAim: Callous and unemotional traits such as the inability to make emotional communication, and the lack of feelings of guilt and empathy are frequently found in the young with antisocial manners, who are at increased risk for violent behavior in the future. We aimed to identify the psychometric properties of the Turkish version of the "Inventory of Callous-Unemotional Traits-Youth Form" (ICU-TR). Materials and Methods: The ICU-TR was administered to 301 students, and only 250 completely filled out forms have been included in the study. One hundred students filled out the ICU-TR 3 weeks later for test-retest reliability. The factor structure of the scale has been studied with principle component analysis, and reliability measured with Cronbach's alpha. Pearson correlation is used for criterion-related validity and test-retest reliability. Results: The mean age of the cases was 14.38, with 68% male and 32% female. Factor analysis supported a two factorial structure. The first factor (callousness) had 12 items (Eigen value=4.8; r=0.58, p<0.001); the second factor (uncaring) had 11 items (Eigen value=2.3; r=0.64, p<0.001). Cronbach's alpha coefficient for the total scale was 0.55, 0.77 for the callousness subscale, and 0.58 for the uncaring subscale. Test-retest reliability coefficient was 0.88 (p<0.001). Conclusion: The construct validity of ICU-TR was shown by factor analysis. The result is that test-retest reliability, sub-scale and total scale reliability are all sufficient.Öğe Reduced blood agmatine level in early-onset schizophrenia(Elsevier, 2020) Baytunca, Burak M.; Kalyoncu, Tugba; Ozbaran, Burcu; Kose, Sezen; Ongur, Dost; Uzbay, Tayfun[No abstract available]Öğe Relationship Between Oxytocin and Attention Deficit Hyperactivity Disorder(Galenos Yayincilik, 2017) Kalyoncu, Tugba; Ozbaran, Burcu; Kose, Sezen; Onay, HuseyinAttention deficit hyperactivity disorder (ADHD), while characterized by attention problems, hyperactivity and impulsivity, essentially is a phenotypically heterogenous disorder. Social cognition disorders are important in ADHD, particularly in children due to their role in difficulties in social relations. Social cognition is crucial for the individual to build relations with others and through such relations inform social behavior. It has been suggested that sub-units of social cognition such as facial recognition and empathy are related to oxytocin. It is thought that individuals diagnosed with ADHD, for whom such skills are less readily available, have difficulties communicating on a social scale. PubMed medical search engine was used to identify the studies and review articles on oxytocin and ADHD. While the oxytocin gene and the oxytocin receptor gene are extensively studied in autism spectrum disorders, data on ADHD is scarce. Oxytocin, known as a mediator of social behavior, also affects the phenotype of ADHD, a disease subject to genetic and environmental influences determining its phenotype and individual case differences.Öğe Relationship of Attention Deficit-hyperactivity Disorder on the Spectrum of Anorexia Nervosa to Obesity: A Case Report(Galenos Yayincilik, 2018) Kalyoncu, Tugba; Baytunca, Burak; Kose, Sezen; Ozbaran, BurcuEating disorders are a growing health problem among adolescents and have increasingly become the focus of studies due to their prevalence. Both obesity and anorexia nervosa are associated maladaptive eating behaviours that may be relevant to development. With this case report, it is intended to discuss the diagnosis and management of a female adolescent patient, diagnosed with obesity and attention deficit-hyperactivity disorder (ADHD). A 16-year-old, female, obese adolescent was referred to our in-patient clinic due to maladaptive eating styles, depressive symptoms and ADHD symptoms. Her early course of illness, diagnostic process, treatment and short-term outcome are described. At the time of discharge, the patient's Clinical Global Impression (CGI) scale severity item score was 2 (borderline mentally ill) and CGI improvement item score was 2 (much improved). We report the present case with the purpose of establishing a pediatric approach to obesity, a disease not included in Diagnostic and Statistical Manual-5 under eating disorders, yet we believe it shares common underlying genetic and environmental causes.Öğe Theory of mind and emotion regulation difficulties in children with ADHD(Elsevier Ireland Ltd, 2018) Ozbaran, Burcu; Kalyoncu, Tugba; Kose, SezenSocial cognition deficits and emotion dysregulation (ED) are frequently separately studied in relation to ADHD. This study aimed to examine the link between theory of mind (ToM) abilities and ED in children with ADHD. Participants were 200 children aged 11-17 years (study group, n = 100; healthy controls, n = 100). Emotion regulation skills were quantified by using the Difficulties in Emotion Regulation Scale (DERS). ToM was quantified by three different tasks. Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision (DSM-IV-TR) Disruptive Behavior Disorders Rating Scale parents form was used for determination of ADHD symptom severity (ADHD-SS). Children in the study group had more overall difficulties regulating their emotions than healthy controls. Within the study group, a significant correlation was found between the scores of DERS-total and ADHD-SS; and between the scores of DERS-total and gender. The linear regression showed that the predictor variables accounted for 56% of the variation in DERS-total. Unexpected Outcomes Test (UOT) scores significantly improved the accountability of the total variance when added to the linear regression. Our findings show that theory of mind deficits may partly explain ED in children with ADHD.Öğe Variation in the Oxytocin Receptor Gene Is Associated With Social Cognition and ADHD(Sage Publications Inc, 2019) Kalyoncu, Tugba; Ozbaran, Burcu; Kose, Sezen; Onay, HuseyinObjective: Children with ADHD show substantial deficits in social cognitive abilities. Oxytocin, mediated through its specific receptor (OXTR), is involved in the regulation of social behavior and social cognition. Method: The entire coding sequence of the human OXT and OXTR genes were sequenced to identify mutations and single nucleotide polymorphisms (SNPs) in 151 children with ADHD (ADHD-combined, n = 51; inattentive subtype, n = 50; ADHD-C plus conduct disorder [CD], n = 50; 11-18 years) and 100 healthy controls. Results: We examined the association of three detected SNPs of OXTR with social cognition deficits. A significant association was shown between the children with ADHD and children with CT/TT genotypes of rs4686302 (chi(2) = 3.695; p = .037). ADHD children with CT/TT genotype for the OXTR rs4686302 performed significantly lower on the facial emotion recognition task than those with CC genotype. Conclusion: OXTR rs4686302 polymorphism was shown to be a genetic marker in social cognition deficits in ADHD children.
