Yazar "Kabaroglu, C" seçeneğine göre listele

Listeleniyor 1 - 8 / 8
  • Küçük Resim Yok
    Öğe
    C-reactive protein and neopterin levels in healthy non-obese adults
    (Walter De Gruyter Gmbh, 2006) Bozdemir, AE; Barutcuoglu, B; Dereli, D; Kabaroglu, C; Habif, S; Bayindir, O
    Background: Obesity and increased waist-to-hip ratio, emphasizing the importance of truncal obesity, have been found to correlate positively with increased cardiovascular disease risk and mortality. Owing to the inflammatory nature of atherosclerosis, the aim of our study was to find possible correlations between body mass index and waist-to-hip ratio, and the inflammatory markers C-reactive protein (CRP) and neopterin in healthy lean and overweight adults. Methods: A total of 49 healthy adults ( mean age 42.4 +/- 1.8 years, 32 females and 17 males) were classified according to their body mass index (BMI) and waist-to-hip ratio values. CRP and neopterin levels were measured. Results: CRP levels were found to be significantly higher in the group with BMI >= 25 kg/m(2) compared to the group with BMI < 25 kg/m(2) ( p = 0.014). Subjects with increased waist-to-hip ratio displayed significantly higher serum CRP and neopterin levels (p = 0.014 and p=0.033, respectively) compared with the group in which the waist-to-hip ratio was < 0.9. A strong positive correlation was found between CRP and BMI in the whole group ( r=0.658, p=0.0001). Conclusions: Grouping overweight subjects according to their waist-to-hip ratio, which is an indicator of truncal obesity, seems to be convenient in studying the inflammatory process in relation to the elevation of adipose tissue. Elevated CRP and neopterin levels may be useful in the assessment of cardiovascular risk in overweight as well as obese subjects.
  • Küçük Resim Yok
    Öğe
    Effect of different levels of cigarette smoking on lipid peroxidation, glutathione enzymes and paraoxonase 1 activity in healthy people
    (Springer, 2005) Solak, ZA; Kabaroglu, C; Cok, G; Parildar, Z; Bayindir, U; Ozmen, D; Bayindir, O
    The purpose of this study was to examine the effect of different levels of cigarette smoking on lipid peroxidation, glutathione enzymes and paraoxonase 1 (PON1) activity in a healthy population. The study included 130 subjects who were classified as mild (<= 10 cigarettes daily, Group I, n=30), moderate (11-20 cigarettes daily, Group 11, n=35), heavy (>20 cigarettes daily, Group III, n=33) and never smokers (controls, Group IV, n=32). Malondialdehyde (MDA) levels, PON1 and erythrocyte glutathione enzyme activities were measured. MDA levels were significantly higher in smokers than never smokers (P<0.05 for Group I, P<0.001 for Group II and III). PON1 activity was significantly lower in heavy smokers (P<0.001). Glutathione peroxidase (GSH-Px) activity was significantly lower in the smokers (P<0.0001). Glutathione reductase (GR) activity was significantly higher in smokers (P<0.0001). MDA levels negatively correlated with PON1 and GSH-PX activities (P<0.01), whereas they positively correlated with GR activities (P<0.001). At every level, cigarette smoking is associated with increased lipid peroxidation and causes an impairment in antioxidant systems.
  • Küçük Resim Yok
    Öğe
    Increased thickness of the carotid artery intima-media assessed by ultrasonography in Behcet's disease
    (Clinical & Exper Rheumatology, 2005) Keser, G; Aksu, K; Tamsel, S; Ozmen, M; Kitapcioglu, G; Kabaroglu, C; Killi, R; Bayindir, O; Doganavsargil, E
    Objective. Behcet's disease (BD), is a unique systemic vasculitis, which affects almost all types and sizes of blood vessels. Carotid intima-media thickness (IMT) is an endothelial cell dysfunction (ECD) parameter which may also be associated with atherosclerosis. We aimed to search carotid IMT and plaque formation in BD, using high-resolution B-mode Doppler ultrasonography (USG). Methods. We studied 114 BD patients (M/F: 68146; mean age 38.15 +/- 9.44 years; disease duration 121 +/- 79 months), being followed tip by Ege University; Rheumatology Department. A e and sex-matched, 77 healthy, controls, and as the disease control group 46 non-matched SLE patients were also included. Exclusion criteria for all the study participants were, hypertension, hyperlipidemia, diabetes mellitus, obesity and history of cardiovascular or cerebrovascular disease. Comparison of the three groups were made by ANOVA and for post-hoc confirmation, Bonferoni test was used. Results. The carotid IMT in BD (mean +/- SD, 0.55 +/- 0.14 min) was significantly higher than in healthy controls (0.48 +/- 0.09 min) (p = 0.004), but signficantly lower than in SLE (0.66 +/- 0.24 mm) (p = 0.001). Likewise, plaque frequency in BD (5/114) was significantly higher than in health), controls (0/77), but significantly lower than in SLE (8146) (p < 0.001). Conclusion. Despite significantly higher carotid IMT and plaque frequency in BD compared with healthy controls, these parameters in BD were not as marked as in SLE. Less severe carotid artery abnormalities in BD, may partially explain why cardiovascular morbidity and mortality do not seem to be increased in BD, unlike in SLE.
  • Küçük Resim Yok
    Öğe
    Nitric oxide and oxidative stress in atherosclerotic renovascular hypertension: Effect of endovascular treatment
    (Lippincott Williams & Wilkins, 2003) Parildar, M; Parildar, Z; Oran, I; Kabaroglu, C; Memis, A; Bayindir, O
    PURPOSE: Because activation of the renin-angiotensin system leads to an increase in oxidative stress, the authors investigated nitric oxide (NO; nitrite + nitrate), superoxide dismutase (SOD), catalase, and malondialdehyde (MDA) levels and the effect of endovascular treatment on these parameters in patients with atherosclerotic renovascular hypertension. The relationship of NO with blood pressure and renal functional indexes was also investigated. MATERIALS AND METHODS: In this prospective cohort study, serum creatinine, NO, SOD, catalase, plasma MDA, urinary microalbumin, and NO levels, and blood pressure were determined in 21 patients with hypertension and unilateral renal artery stenosis caused by atherosclerosis at entry and after 24 hours, 2 weeks, and 6 weeks of endovascular treatment. RESULTS: MDA concentrations decreased 24 hours after intervention and remained low 2 and 6 weeks later. In addition, serum SOD and NO and urine NO levels were increased significantly 24 hours after endovascular treatment and decreased after 2 and 6 weeks. However, serum catalase levels did not differ after the intervention. Blood pressures decreased after treatment. There were no significant differences in urinary microalbumin levels, estimated glomerular filtration rates, and creatinine levels after endovascular treatment. CONCLUSIONS: Endovascular treatment decreases oxidative stress and may offer new benefits in the treatment of patients with hypertension associated with renal artery stenosis. The decrease in oxidative stress and/or the upregulation of SOD may increase the bioavailability of NO, which in turn may lead to the rapid hypotensive response.
  • Küçük Resim Yok
    Öğe
    Nitric oxide and oxidative stress in atherosclerotic renovascular hypertension: Effect of endovascular treatment
    (Lippincott Williams & Wilkins, 2003) Parildar, M; Parildar, Z; Oran, I; Kabaroglu, C; Memis, A; Bayindir, O
    PURPOSE: Because activation of the renin-angiotensin system leads to an increase in oxidative stress, the authors investigated nitric oxide (NO; nitrite + nitrate), superoxide dismutase (SOD), catalase, and malondialdehyde (MDA) levels and the effect of endovascular treatment on these parameters in patients with atherosclerotic renovascular hypertension. The relationship of NO with blood pressure and renal functional indexes was also investigated. MATERIALS AND METHODS: In this prospective cohort study, serum creatinine, NO, SOD, catalase, plasma MDA, urinary microalbumin, and NO levels, and blood pressure were determined in 21 patients with hypertension and unilateral renal artery stenosis caused by atherosclerosis at entry and after 24 hours, 2 weeks, and 6 weeks of endovascular treatment. RESULTS: MDA concentrations decreased 24 hours after intervention and remained low 2 and 6 weeks later. In addition, serum SOD and NO and urine NO levels were increased significantly 24 hours after endovascular treatment and decreased after 2 and 6 weeks. However, serum catalase levels did not differ after the intervention. Blood pressures decreased after treatment. There were no significant differences in urinary microalbumin levels, estimated glomerular filtration rates, and creatinine levels after endovascular treatment. CONCLUSIONS: Endovascular treatment decreases oxidative stress and may offer new benefits in the treatment of patients with hypertension associated with renal artery stenosis. The decrease in oxidative stress and/or the upregulation of SOD may increase the bioavailability of NO, which in turn may lead to the rapid hypotensive response.
  • Küçük Resim Yok
    Öğe
    Nitric oxide levels in Behcet's disease
    (Medimond Publishing Co, 2003) Kabaroglu, C; Parildar, Z; Aksu, K; Keser, G; Oksel, F; Bayindir, O; Park, AJ
    Behcet's syndrome (BS) is a chronic, multisystem disorder characterized by vasculitis. Approximately 25% of patients with Behcet's syndrome develop vascular complications, which may include superficial thrombophlebitis, deep vein and arterial thrombosis and arterial aneursym formation. The purpose of the present study was to evaluate the importance of serum nitrate (NO, nitrate) levels in the pathogenesis of vascular complications observed in Behcet's syndrome. 65 patients and 30 healthy volunteers were included in the study. The subjects were studied after an overnight fast, and blood samples were collected for glucose, ALT, AST, total cholesterol., triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL), homocysteine, folic acid, vitamin B-12 nitrate + nitrite (NO) and C-reactive Protein (CRP) levels and erythrocyte sedimantation rates (ESR). Scrum nitrate levels of patients with BS were found to be decreased when compared with the control (p<0,001).
  • Küçük Resim Yok
    Öğe
    Nitric oxide levels in Behcet's disease
    (Medimond Publishing Co, 2003) Kabaroglu, C; Parildar, Z; Aksu, K; Keser, G; Oksel, F; Bayindir, O; Park, AJ
    Behcet's syndrome (BS) is a chronic, multisystem disorder characterized by vasculitis. Approximately 25% of patients with Behcet's syndrome develop vascular complications, which may include superficial thrombophlebitis, deep vein and arterial thrombosis and arterial aneursym formation. The purpose of the present study was to evaluate the importance of serum nitrate (NO, nitrate) levels in the pathogenesis of vascular complications observed in Behcet's syndrome. 65 patients and 30 healthy volunteers were included in the study. The subjects were studied after an overnight fast, and blood samples were collected for glucose, ALT, AST, total cholesterol., triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL), homocysteine, folic acid, vitamin B-12 nitrate + nitrite (NO) and C-reactive Protein (CRP) levels and erythrocyte sedimantation rates (ESR). Scrum nitrate levels of patients with BS were found to be decreased when compared with the control (p<0,001).
  • Küçük Resim Yok
    Öğe
    Treatment and prophylaxis with sucralfate ameliorates hypoxia/reoxygenation-induced intestinal injury in pup rats
    (Int Scientific Information, Inc, 2005) Sencan, AB; Sencan, A; Aktas, S; Habif, S; Kabaroglu, C; Parildar, Z; Karaca, I