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Öğe Antenatal Findings of Keratitis-Ichthyosis-Deafness Syndrome(Elsevier Inc, 2020) Okmen F.; Hortu I.; Jafarova U.; Imamoglu M.; Ekici H.; Ergenoglu A.M.Background: Keratitis-ichthyosis-deafness (KID) syndrome is a congenital ectodermal disorder characterized by keratitis, ichthyosis, and deafness. This syndrome affects multiple systems and can be fatal. Case: A 34-year-old G2, P1 woman was admitted to the Ege University School of Medicine in Izmir, Turkey because of a rapid increase in abdominal circumference at 32 weeks gestation. Fetal anatomic screening revealed complete chorioamniotic separation, hypoplasia of the cerebellar vermis, and dysmorphic facial findings such as frontal bulging. After the delivery, the baby's whole body had granular thickened skin. Bilateral dry eye, corneal edema, and bilateral retinopathy of prematurity were diagnosed. Conclusion: This case report highlights the importance of prenatal diagnosis through ultrasonography and magnetic resonance imaging. This is the first case report that has antenatal ultrasonographic features in the literature. © 2019 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada.Öğe Antenatal Findings of Keratitis-Ichthyosis-Deafness Syndrome(Elsevier Inc, 2019) Okmen F.; Hortu I.; Jafarova U.; Imamoglu M.; Ekici H.; Ergenoglu A.M.Background: Keratitis-ichthyosis-deafness (KID) syndrome is a congenital ectodermal disorder characterized by keratitis, ichthyosis, and deafness. This syndrome affects multiple systems and can be fatal. Case: A 34-year-old gravida 2, para 1 woman was admitted to the Ege University School of Medicine in Izmir, Turkey because of a rapid increase in abdominal circumference at 32 weeks gestation. Fetal anatomic screening revealed complete chorioamniotic separation, hypoplasia of the cerebellar vermis, and dysmorphic facial findings such as frontal bulging. After the delivery, the baby's whole body had granular thickened skin. Bilateral dry eye, corneal edema, and bilateral retinopathy of prematurity were diagnosed. Conclusion: This case report highlights the importance of prenatal diagnosis through ultrasonography and magnetic resonance imaging. This is the first case report that has antenatal ultrasonographic features in the literature. © 2019 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada.Öğe Cancer and cancer stem cells: New molecular perspectives(Begell House Inc., 2019) Gurel C.; Inetas G.; Hortu I.; Tunc E.; Kuscu G.C.; Dindaroglu F.C.; Sahin O.; Buhur A.; Oktema G.Cancer, which causes the deaths of millions of people, is an important public health problem worldwide. Despite significant advances in the diagnosis and treatment of cancer, survival rates are still insufficient in progressive cancers. Today, one of the most important reasons for not being able to reach the desired level in the fight against progressive cancer types is cancer stem cells (CSCs). The ineffectiveness of conventional therapies on CSCs has made it necessary to investigate the molecular mechanisms and signaling pathways used in the survival, drug resistance, and metastasis of CSCs. In this context, studies investigating the biology of CSCs suggest that lipid metabolism and extracellular vesicles are critical for understanding the stemness and metastasis of these cells. These studies have demonstrated that a number of molecules play a vital role in resistant to apoptosis in CSCs, including the cellular FLICE-inhibitor protein (c-FLIP), which inhibits TRAIL-induced extrinsic apoptosis. Another important output of these studies is the demonstration of the relationship of the cancer microenvironment in terms of epithelial-mesenchymal transition, which CSCs frequently use in the metastasis process. In addition, studies investigating the differences in glycosylation observed in CSCs and investigating cancer vaccines are promisng. These findings will strengthen our aresnal in the fight against cancer. In this article, we summarize current molecular studies on CSCs, an important target in novel cancer therapies. © 2019 Begell House, Inc.Öğe Granuler cell tumor of vulva: A case report and review of the literature [Vulvanin granüler hücreli tümörü: Olgu sunumu ve literatürün gözden geçirilmesi](Gunes Kitap Kirtasiye, 2014) Hortu I.; Ergenoglu A.M.; Zeybek B.; Akdemir A.; Yeniel A.Ö.Granular cell tumors are unusual neoplasms presumably derived from Schwann cells. These tumors are mostly seen in head and neck area and 5.3%of cases are localized in the vulva. Although most of the cases are benign, macroscopically they are poorly circumscribed and show adherence to the surrounding connective tissue. Malignant transformation was also reported and recurrence is common in these patients. In this case report, a vulvar granular cell tumor is presented and discussed in a 59-yearold woman with a history of unilateral mastectomy due to breast cancer. © 2014, Gunes Kitap Kirtasiye, All rights reserved.Öğe Granulocyte Colony-Stimulating Factor Prevents Ischemia/Reperfusion-Induced Ovarian Injury in Rats: Evaluation of Histological and Biochemical Parameters(SAGE Publications Inc., 2018) Hortu I.; Ozceltik G.; Sahin C.; Akman L.; Yildirim N.; Erbas O.Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein commonly used in the field of medicine to treat neutropenia. Granulocyte colony-stimulating factor has also crucial roles in ameliorating the ischemia/reperfusion (I/R) injury in particular tissues. In this study, we aimed to investigate the protective effect of G-CSF on ovarian damage in experimental ovarian I/R injury. Thirty adult female rats were used. Rats were separated randomly into 5 groups; Group 1: sham group (abdominal wall was opened and closed surgically), Group 2: torsion group with 3-hour ischemia using vascular clips. Group 3: torsion + G-CSF group with 3-hour ischemia 30 minutes after the administration intraperitoneal (i.p.) of 100 µg/kg of G-CSF. Group 4: torsion-detorsion group with 3 hour ischemia and 3 hour reperfusion. Group 5: torsion-detorsion + G-CSF group with 3 hour ischemia followed by 100 µg/kg of G-CSF i.p. administration 30 minutes prior to 3 hour of detorsion/reperfusion. Ovarian tissue damage was scored on histopathology. Ovarian tissue malondialdehyde (MDA) was measured biochemically. In comparison with the sham group, both the torsion and torsion-detorsion groups had significantly higher scores for follicular degeneration, vascular congestion, edema, hemorrhage, and leukocyte infiltration (P <.05). When compared group torsion-detorsion + G-CSF to group torsion-detorsion, parameters aforementioned significantly decreased in group torsion-detorsion + G-CSF (P <.05). Granulocyte colony-stimulating factor has also decreased MDA levels notably both in the torsion + G-CSF and torsion-detorsion + G-CSF groups (P <.05, P <.01). Our experimental study suggests that G-CSF can be a novel agent for the treatment of ovarian I/R injury. © The Author(s) 2018.Öğe Large mucinous neoplasm of the appendix mimicking adnexal mass in a postmenopausal woman(Elsevier Ltd, 2014) Akman L.; Hursitoglu B.S.; Hortu I.; Sezer T.; Oztekin K.; Avsargil B.D.INTRODUCTION: Appendiceal tumors are rare, late-diagnosed neoplasms that may not be differentiated from adnexal masses even by advanced imaging methods and other diagnostic procedures. They may be asymptomatic and remain undiagnosed until surgery. PRESENTATION OF CASE: We report a case of 81-year-old postmenopausal woman presented with abdominal pain. A magnetic resonance imaging revealed right adnexal mass. Laparotomy was performed and detected a 12 cm × 9 cm mucinous tumoral mass arising in the appendix. An appendectomy and a right hemicolectomy with ileo-transverse anastomosis were performed. Histopathological examination was revealed appendiceal mucinous neoplasm with low malignancy potential. DISCUSSION: Gastrointestinal tumors such as appendiceal tumors can mimicking adnexal mass. Therefore, appendiceal tumor kept in mind in a patient with diagnosed adnexal mass, especially patient had non-specific clinical symptoms, laboratory and radiologic findings. CONCLUSION: Gastrointestinal tumors such as appendiceal tumors kept in mind in a patient with diagnosed adnexal mass. © 2014, Elsevier Ltd. All rights reserved.Öğe Neural tube defect with parasitic rachipagus twin (heteropagus): Case report [Nöral Tüp Defekti ile Birliktelik Gösteren Rasipagus Parazitik Ikiz (Heteropagus)](OrtadogÂ?u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2016) Hortu I.; Ergenoglu A.M.; Yeniel A.Ö.; Özçeltik G.Conjoined twins are a congenital musculo-skeletal anomaly that can be seen 1/50.000-1/100.000. It occurs 12-13 days after fertilization via incomplete and late division of monozygotic embryonic disc. They can be named with depending on the anatomical location of the sticking points of twin pairs. Furthermore it may accompany other malformations. Parasitic twinning (heteropagus twinning) is a much rarer form of conjoined twinning. In this case report, a patient who was diagnosed with neural tube defect and rachipagus twinning at 19 weeks presented. Copyright © 2016 by Türkiye Klinikleri.
