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Öğe How familiar are doctors in Turkey with hereditary angioedema?(Wiley-Blackwell, 2013) Gokmen, N. M.; Gulbahar, O.; Koc, Z. P.; Ardeniz, O.; Gurlek, F.; Sin, A.; Kokuludag, A.; Gelincik, A.; Buyukozturk, S.Öğe The impact of hereditary angioedema on patients' daily life(Wiley-Blackwell, 2013) Gulbahar, O.; Gokmen, N. M.; Erdogan, A. P.; Erdogdu, D.; Koc, Z. P.; Sin, A. Z.; Ardeniz, O.; Gurlek, F.; Buyukozturk, S.; Gelincik, A.; Kokuludag, A.Öğe Prevalence of cypress pollen sensitization and its clinical importance in Izmir, Turkey, with cypress allergy assessed by nasal provocation(Esmon Publicidad S A, 2008) Sin, A. Z.; Ersoy, R.; Gulbahar, O.; Ardeniz, O.; Gokmen, N. M.; Kokuludag, A.Background and objective: Pollens from the Cupressaceae family are considered important allergens in the Mediterranean area, though reports of the prevalence of allergic symptoms have ranged from 1.04% to 35.4%. Our aim was to detect the prevalence of cypress pollen sensitization and determine its clinical importance in patients with seasonal respiratory allergy. Methods: We used skin prick tests (SPT) and serum specific IgE assays to reveal sensitization to cypress pollen. In patients who showed positive results to cypress pollen, a nasal provocation test (NPT) with pollen extract was used to assess the target organ response. Results: Sixty-five (14.3%) of 455 patients showed positive SPT responses to Cupressus sempervirens extract. Only I patient was monosensitized while 64 patients were polysensitized. Among those, 2 pollen cosensitizations were found to be significant (86% were cosensitized to grasses and 72% were cosensitized to olive (P <.001). Serum specific IgE to cypress pollen was measured in 50 of the 65 patients; findings were positive for 37. When these 37 patients underwent NPT with C sempervirens allergen extract, only the single monosensitized patient had a positive NPT. Conclusion: A positive SPT to cypress pollen may not reflect the true prevalence of sensitization. We assume that in the absence of a positive NPT, positive SPT results might be related to the presence of cross-reactivity between pollen species.Öğe Subcutaneous immunotherapy with single or multiple allergens in monosensitised or polysensitised patients: clinical efficacy and the effects on health-related quality of life(Wiley-Blackwell, 2013) Erdogan, A. P.; Sin, A. Z.; Koc, Z. P.; Kose, T.; Gurlek, F.; Ardeniz, O.; Gulbahar, O.; Gokmen, N. M.; Kokuludag, A.
