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Öğe Analysis of genetic mutations in patients with hereditary angioedema (HAE) type I identified one family with novel homozygous mutation indicating rare instance of autosomal recessive inheritance(Blackwell Publishing, 2008) Kesim, B.; Buyukozturk, S.; Gelincik, A.; Eraslan, S.; Uzumcu, A.; Mete, N.; Sin, A.; Ozseker, F.; Erdenen, F.; Colakoglu, B.; Dal, M.; Uyguner, O.Öğe Cutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish population(Mattioli 1885, 2018) Buyukozturk, S.; Kekik, C.; Gokyigit, A. Z.; Filik, F. I. Tezer; Karakaya, G.; Saygi, S.; Dursun, A. B.; Kirbas, S.; Tufekci, A.; Sin, A. Z.; Aydogdu, I.; Sorgun, M. H.; Aydin, N.; Gelincik, A.; Colakoglu, B.; Celik, G.; Oguz, F.Background and objective. Many studies have shown associations between HLAB*15: 02, HLA-A*31: 01 and carbamazepine (CBZ)-induced delayed cutaneous hypersensitivity reactions. The aim of this study is to evaluate a possible association between delayed cutaneous reactions to antiepileptic drugs (AEDs) and certain HLA-A and HLA-B alleles in the Turkish population. Methods. The study consisted of 3 groups: Group I (reactive group) included the patients who had documented delayed cutaneous reactions to any antiepileptic drug. Group II (non-reactive group) included the patients who have been on antiepileptic treatment at least for three months without any adverse reactions. Group III consisted of healthy subjects. The HLA-A and B alleles were analyzed in all groups. Results. Forty patients (29 female) had experienced different hypersensitivity reactions due to AEDs: maculopapular exanthema (26 patients), Stevens-Johnson syndrome (6 patients), drug rash with eosinophilia and systemic symptoms (7 patients), toxic epidermal necrolysis (1 patient). Lamotrigine (11) and CBZ (10) were the most common culprit drugs involved in the reactions. The HLA-B*15: 02 was not present in any of the study groups. However, HLA-B* 35: 02 was found in 4 patients from the reactive group, while it was not observed in non-reactive patients and was detected in only one healthy subject (p = 0.021). Conclusion. Although our preliminary results did not indicate a strong allele association with AED hypersensitivity, HLA-B* 35: 02 appears to be a candidate allele for MPE /DRESS /DIHSS induced by AED's in Turkish population. Further studies with a larger sample size may result in more comprehensive data about the genetic tendency for AED hypersensitivity in the Turkish population.Öğe Drug allergy in tertiary care in Turkey: Results of a national survey. The ADAPT study: Adult drug allergy perception in Turkey(Elsevier Doyma Sl, 2014) Celik, G. E.; Karakaya, G.; Ozturk, A. B.; Gelincik, A.; Abadoglu, O.; Sin, A.; Damadoglu, E.; Yilmaz, I.; Demirturk, M.; Dursun, B.; Ozdemir, S. K.; Celikel, S.; Degirmenci, P.; Bozkurt, B.; Goksel, O.; Erkekol, F. O.; Aydin, O.; Kavut, A. B.; Kirmaz, C.; Kalpaklioglu, F.; Buyukozturk, S.; Kalyoncu, F.Background: No data are available on the incidence of drug hypersensitivity (DH) reactions in outpatient settings of tertiary allergy/immunology clinics. Our aims were to document the frequency of outpatient hospital admissions due to DH reactions to allergy/immunology clinics in adults and the management of these reactions in real life. We also investigated whether drug allergy affected social and medical behaviours of the patients. Methods: This multi-centre study was performed for one year with the participation of 11 out of 16 tertiary allergy/clinical immunology clinics in Turkey. The study group consisted of the patients with DH reactions. Results of a questionnaire including drug reactions and management were recorded. Results: Among 54,863 patients, 1000 patients with DH were enrolled with a median of 2.1% of all admissions. In real life conditions, the majority of approaches were performed for finding safe alternatives (65.5%; 1102 out of 1683) with 11.7% positivity. Diagnostic procedures were positive in 27% (154/581) of the patients. The majority of the patients had higher VAS scores for anxiety. A total of 250 subjects (25%) reported that they delayed some medical procedures because of DH. Conclusion: Our results documented the frequency of admissions due to DH reactions to allergy/clinical immunology clinics for the first time. Although physicians mostly preferred to perform drug tests in order to find safe alternatives, considering the fact that DH was confirmed in 27% of the patients, use of diagnostic tests should be encouraged, if no contraindication exists in order to avoid mislabelling patients as DH. (C) 2013 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Genotype has impact on complement proteins in patients with hereditary angioedema(Wiley, 2017) Gokmen, Mete N. M.; Onay, H.; Koc, Peker Z.; Gulbahar, O.; Sin, A.; Buyukozturk, S.; Gelincik, A.Öğe HLA-A and HLA-B alleles in Turkish patients with severe anti-epileptic drug allergy(Wiley-Blackwell, 2016) Buyukozturk, S.; Kekik, C.; Aysen, G. Z.; Karakay, G.; Saygi, S.; Tezer-Filik, I. F.; Dursun, B. A.; Kirbas, S.; Tufekci, A.; Sin, A. Z.; Aydogdu, I; Celik, G.; Aydin, N.; Gelincik, A.; Colakoglu, B.; Fatma, O.Öğe How familiar are doctors in Turkey with hereditary angioedema?(Wiley-Blackwell, 2013) Gokmen, N. M.; Gulbahar, O.; Koc, Z. P.; Ardeniz, O.; Gurlek, F.; Sin, A.; Kokuludag, A.; Gelincik, A.; Buyukozturk, S.Öğe The impact of hereditary angioedema on patients' daily life(Wiley-Blackwell, 2013) Gulbahar, O.; Gokmen, N. M.; Erdogan, A. P.; Erdogdu, D.; Koc, Z. P.; Sin, A. Z.; Ardeniz, O.; Gurlek, F.; Buyukozturk, S.; Gelincik, A.; Kokuludag, A.Öğe No effect of antihypertensive drugs on severity of anaphylaxis and side-effects during venom immunotherapy(Wiley, 2019) Arzt-Gradwohl, L.; Schrautzer, C.; Laipold, K.; Herzog, S. A.; Stoevesandt, J.; Trautmann, A.; Vachova, M.; Hawranek, T.; Lang, R.; Alfaya Arias, T.; Chelminska, M.; Kita, K.; Pravettoni, V; Gawlik, R.; Ruiz-Leon, B.; Antolin-Amerigo, D.; Mauro, M.; Boni, E.; Preziosi, D.; Bonadonna, P.; Ernst, B.; Sin, B. A.; Kendirlinan, R.; Gelincik, A.; Sin, A.; Nittner-Marszalska, M.; Rosiek-Biegus, M.; Quercia, O.; Bozek, A.; Reider, N.; Marchi, F.; Poziomkowska-Gesicka, I; Serrano, P.; Jimenez Blanco, A.; Kosnik, M.; Frelih, N.; Hoetzenecker, W.; Sturm, G.Öğe Psychiatric and Clinical Characteristics of Hereditary Angioedema Patients Who Experienced Attacks During COVID-19(Esmon Publicidad S A, Dept Allergy & Clin Immunol, Clin Univ Navarra, 2021) Gokmen, Mete N.; Tuncel, Kuman O.; Bogatekin, G.; Bulut, G.; Demir, S.; Gelincik, A.; Dalgic, Tunakan C.[No Abstract Available]Öğe The role of component resolved diagnosis in hymenoptera venom allergy(Wiley, 2019) Engin, A.; Oktelik, F. B.; Gelincik, A.; Sin, A.; Sin, B. A.; Dursun, B. A.; Beyaz, S.; Gorgulu, B.; Cetin, E.; Deniz, G.Öğe The Turkish hereditary angioedema pilot study: the first Turkish series of hereditary angioedema(Wiley-Blackwell, 2011) Kesim, B.; Uyguner, Z.; Gelincik, A.; Gokmen, Mete N.; Sin, Z.; Karakaya, G.; Erdenen, F.; Ardeniz, O.; Ozseker, F.; Gulbahar, O.; Colakoglu, B.; Dal, M.; Buyukozturk, S.
