Yazar "Ertan Y." seçeneğine göre listele

Listeleniyor 1 - 20 / 31
  • Küçük Resim Yok
    Öğe
    Acute lymphoblastic leykemia in apatient with wilson disease treated with D-pencillamine
    (2006) Sahin F.; Saydam, G..; Sahin O.; Ocakci S.; Ertan Y.; Akarca U.S.; Tombuloglu M.
    Wilson disease (WD) is a rare inherited disease of copper metabolism, characterized by liver and central nervous system dysfunction. It is usually associated with some other diseases such as autoimmune disorders and malignancies. We hereby report a case with diagnosis of acute lymphoblastic leukemia which developed in the course of WD under the treatment of D-penicillamine. Twenty five years old female patient was diagnosed WD ten years ago. Therapy was started with D-penicillamine, zinc sulfate and a low copper diet has been given during the course of the disease. The disease has been under control for the last ten years. She was admitted to the hospital with complaints of pallor, fatigue, fever and ecchymoses. The diagnosis was acute lymphoblastic leukemia (ALL) according to bone marrow analysis. Although she responded to remission/induction regimen, she relapsed in early period and accepted as refractory disease after 2 cycles of intensive chemotherapy regimen. Coexistence of WD and acute leukemia is very rare phenomenon although genetical and etiological background of these two entities could not be enough for explanation of this co-existence so far. It is also not clearly documented yet whether WD induces leukemia or D-penicillamine could cause additional malignancy. Further investigations are still needed to clarify this situation. Copyright © Hellenic Society of Haematology.
  • Küçük Resim Yok
    Öğe
  • Küçük Resim Yok
    Öğe
    Central nervous system angiosarcoma: A case report [Santral sinir sistemi anjiyosarkomu: Bir olgu sunumu]
    (Turkish Neurosurgical Society, 2018) Sarı Ü.S.; Ayşin Kısabay A.; Ovalı G.Y.; Mavioğlu H.; Zeybek S.; Özgiray E.; Sarı M.F.; Ertan Y.
    [No abstract available]
  • Küçük Resim Yok
    Öğe
    A Clear Cell Variant of Papillary Thyroid Microcarcinoma With Lung, Bone, and Soft Tissue Metastases
    (2015) Yazici B.; Ertan Y.; Oral A.; Akgün A.
    A 56-year-old woman presented with a mass lesion on the right occipital bone underwent total resection of the tumor. An adenocarcinoma with immunostaining positive for thyroid transcription factor-1 and thyroglobulin was found. An ultrasound/thyroid scan detected a hot nodule of 9 mm in the right lobe. Fine needle biopsy revealed the similar histological findings with the previous bone resection material. Then, a total thyroidectomy was performed. Histopathologic examination revealed clear cell variant of papillary thyroid microcarcinoma. She received 7.4 GBq of I. On posttherapy scan, metastatic focuses were seen in the left lung and soft tissue between the left paravertebral muscles.
  • Küçük Resim Yok
    Öğe
    Complete disappearance of bone lesions with high dose chemotherapy supported with autologous stem cell transplantation in primary bone lymphoma
    (2006) Sahin F.; Simsir I.Y.; Ertan Y.; Sever A.; Buyukkececi F.; Saydam, G..
    Primary bone lymphoma is a rare group of lymphomas. Histologically, the most common type of primary bone lymphoma is diffuse large cell type and of intermediate type. We present a case with primary bone lymphoma and treated with 8 cycles of CHOP regimen resulted with partial response with persisting bone lesions. High dose chemotherapy and autologous peripheral blood stem cell transplantation was performed two years after of diagnosis and, osteolytic lesions on the bones completely disappeared after this treatment. The patient is still in remission without any new bone events and with normal clinical and laboratory findings. Complete disappearance and durable complete remission of bone lesions in primary bone lymphoma is very rare, even after high dose chemotherapy. Copyright © Hellenic Society of Haematology.
  • Küçük Resim Yok
    Öğe
    The correlation of clinicopathological findings and neutrophil-to- lymphocyte and platelet-to-lymphocyte ratios in papillary thyroid carcinoma [Papiller tiroid kanserli hastalarda nötrofil/lenfosit ve trombosit/lenfosit oranlarinin kliniko- patolojik bulgularla iliskisi]
    (Galenos, 2019) Ceylan Y.; Kumanlioğlu K.; Oral A.; Ertan Y.; Özcan Z.
    Objectives: Inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been recently introduced as potential biomarkers for tumor pathogenesis, development and prognosis in solid tumors. Our aim was to assess the correlation of clinicopathological features and NLR and PLR in patients with papillary thyroid carcinoma (PTC). Methods: A total of 201 papillary thyroid carcinoma patients were divided into groups with a cut-off preoperative median NLR and PLR value of 1,92 and 123.9, respectively. The correlation of NLR and PLR and clinicopathological features including age, tumor size, extra-thyroidal extension, thyroid capsule invasion, surgical margin positivity, multifocality, bilaterality of the patients were analyzed. Results: The mean NLR and PLR were 2.11±0.94, 129.69±42.81, respectively. Larger tumor size and higher positivity of extra-thyroidal spread were correlated with higher NLR values. No significant relationship was found between NLR and age, presence of thyroid capsule invasion, surgical margin positivity, multifocality, bilaterality, and lymph node metastasis. Also no significant association was observed between the clinicopathological features and PLR. Conclusion: High NLR was found to correlate with tumor size and extra-thyroidal extension. NLR may be used as a marker to determine the clinical behavior of disease in patients with papillary thyroid carcinoma (PTC). © 2019 by Turkish Society of Nuclear Medicine.
  • Küçük Resim Yok
    Öğe
    Could retroperitoneal ganglioneuroma be a dopamine secreting ganglioneuroma? [Retroperitoneal ganglionöroma dopamin salgılayan bir ganglionöroma olabilir mi?]
    (Turkiye Klinikleri, 2018) Özışık H.; Yürekli B.S.; Özdemir Kutbay N.; Eker B.; Ertan Y.; Saygili F.
    Ganglioneuromas are rarely occurring benign tumors characterized by hyperplasia of mature ganglia and satellite cells. They are well-differentiated, slow growing, and autonomous nervous system neoplasms, which are usually asymptomatic and do not release any hormones. A male patient aged 26 years was evaluated for secondary hypertension six months ago. Ultrasonography of the abdomen revealed a mass lesion around the right kidney. An analysis of the 24-hour urine sample of the patient revealed the following parameters: 5-HİAA=3.9 mg/day (2-7), metanephrine=56.3 µg/day (52-341), and normetanephrine=146.1 µg/day (88-444). The computed tomography scan of the abdomen showed a retroperitoneal mass of 10 cm in size, containing minute calcified foci in the right retroperitoneal region. The mass was excised through general surgery and was classified as ganglioneuroma. The blood pressure of the patient returned to normal level after surgery, and he needed no further antihypertensive treatment. Besides, the metanephrine and normetanephrine levels in the 24-hour urine were also observed to be normal as in the preoperative period. Retroperitoneal masses can actually be ganglioneuromas and an accurate diagnosis can be achieved only through postoperative histopathological evaluation. After the operation, blood pressure of the patient returned to normal. This suggests that retroperitoneal ganglioneuroma could possibly secrete dopamine, epinephrine, or norepinephrine. © 2018 by Turkish Journal of Endocrinology and Metabolism Association.
  • Küçük Resim Yok
    Öğe
    The differential diagnosis of lymphocyte-rich classical Hodgkin's lymphoma and lymphocyte predominant Hodgkin's lymphoma using the R.E.A.L. criteria. An immunohistochemical study on 45 cases
    (2000) Hekimgil M.; Soydan S.; Doganavsargil Yakut B.; Ertan Y.
    In the present study, the two types, lymphocyte-rich classical HL (LRCHL) and nodular lymphocyte-predominant type (NLPHL), which were grouped together before the R.E.A.L. classification, were questioned on the basis of differential criteria and 45 cases were retrieved from last ten years' archival material. On histopathological examination, nodular pattern, the cytological features and intensity of Reed-Sternberg (RS) cells, the pattern and intensity of histiocytes, the presence of germinal centers with progressive transformation were analysed. An immunohistochemical study was performed using antibodies against CD20, CD45RO, CD3, CD30, CD15 antigens and streptavidin-biotin procedure. The cases were classified into three groups according to the histologic pattern and immunophenotypical features of the RS cells: 1) diffuse, LRCHL (CD20-, CD30+/-, CD15+/-): n= 28; II) NLPHL (CD20+, CD30-, CD15-): n= 11; III) cases which could not be evaluated in former groups: n= 6. Four cases in the latter group showed a nodular pattern with RS cells negative for all markers, except for one case, which expressed both CD20 and CD15. The remaining two cases exhibited a diffuse pattern and the RS cells were CD20+, coexpressing CD30 in one. These findings suggest that, differential diagnosis according to the R.E.A.L. criteria is not distinctive between the two categories of HL in about 13% of cases, and further criteria need to be established to define the grey zone between the two entities which might lead to further therapeutic trials.
  • Küçük Resim Yok
    Öğe
    Esophageal metastasis of hurthle cell thyroid carcinoma eight years after a subtotal thyroidectomy that mimicked esophageal hemangioma [4]
    (Blackwell Publishing, 2005) Akyildiz M.; Ozutemiz O.; Gunsar F.; Akay S.; Aydin A.; Elmas N.; Ertan Y.; Akyildiz M.; Ilter T.
    [No abstract available]
  • Küçük Resim Yok
    Öğe
    Evaluation of the role of Epstein-Barr virus in cases of nodal or extranodal T- and NK-cell lymphoma using eber in situ hybridization
    (Versalius University Medical Publisher, 2015) Karaarslan S.; Hekimgil M.; Soydan S.; Ertan Y.; Doğanavşargil B.
    Various racial and geographic differences have been observed in studies questioning the role of Epstein-Barr virus (EBV) infection in the etiology of T- and NK-cell lymphomas. The aim of this study was to evaluate the relationship of EBV with nodal or extranodal (skin excluded) T- and NK-cell lymphoma subtypes encountered in our geographic area. Sixty-two cases of peripheral T-cell lymphoma were included in the study. EBV-encoded early RNA (EBER) was detected by in situ hybridization. The distributions of T- and NK-cell lymphoma subtypes were as follows: 32 peripheral T-cell lymphomas, unspecified (PTCL, NOS), 13 anaplastic large-cell lymphomas (ALCL), 8 angioimmunoblastic T-cell lymphomas (AITCL), 4 extranodal NK/T-cell lymphomas, nasal type (NKTCL), 3 enteropathy-type T-cell lymphomas (ETTCL), 1 hepatosplenic T-cell lymphoma (HSTCL), and 1 subcutaneous panniculitis-like T-cell lymphoma (SPTCL). Using a cut-off value of > 25% of EBER-positive neoplastic lymphoid cells, EBV was positive in 22.6% of all cases. According to subtype, the neoplastic cells of 31.3% of PTCL, NOS and 100% of extranodal NKTCL, nasal type were EBER positive, whereas some cases of ALCL, AITCL, and ETTCL presented EBER-positive non-neoplastic cells, and all cells of HSTCL and SPTCL were EBV negative. Extranodal NKTCL, nasal type, presented the strongest association with EBV, followed by PTCL, NOS. © 2015, Versalius University Medical Publisher. All rights reserved.
  • Küçük Resim Yok
    Öğe
    Hemophagocytic syndrome with erythrocyte phagocytosis by the myeloid precursors in a patient with AML-M2
    (2008) Yilmaz M.; Vural F.; Töbü M.; Ertan Y.; Büyük F.
    Hemophagocytic syndrome is characterized by fever, fatigue, weight loss, lymphadenopathy, and laboratory abnormalities including pancytopenia, liver dysfunction, hypertriglyceridemia and hyperfibrinemia. Histopathologically, lesions are characterized by mononuclear cell infiltration with marked histiocyte proliferation and phagocytosis of erythrocytes, leukocytes, platelets and their precursors by activated macrophages in the reticuloendothelial tissues. Hemophagocytic syndrome may develop from strong immunological stimuli such as severe infection, malignancy and autoimmune diseases. We present a 73-year-old man with acute myeloblastic leukemia FAB M2 type (AML M2) whose bone marrow histology showed unusual hemophagocytosis by myeloid cells and myeloblasts. © Turkish Society of Hematology.
  • Küçük Resim Yok
    Öğe
    Histopathologic and immunophenotypic features of childhood and adult anaplastic large-cell lymphomas
    (2001) Hekimgil M.; Soydan S.; Nart D.; Ertan Y.; Veral A.; Çagirgan S.; Çetingül N.
    The t(2;5) (p23; q35) translocation associated with CD30-positive anaplastic large-cell lymphoma (ALCL) creates a hybrid gene encoding the chimeric nucleolar protein nucleophosmin-anaplastic lymphoma kinase (NFM-ALK) protein, which can be demonstrated by immunostaining with ALK1 monoclonal antibody. In this study, 40 specimens of ALCL from 6 pediatric, 34 adult patients, were immunostained with monoclonal antibodies against CD30 (Ber-H2), EMA, CD45 (LCA), CD3, CD20 (L26), CD15, and ALK1 antigens, and results were correlated with histopathologic features. The mean age of the pediatric and adult patients was 10-years and 38-years, respectively. ALK1 was positive in 14 cases (35%) representing 83% of pediatric and 26% of adult patients, statistically significantly higher in the pediatric group (p= 0.01). Considering the better prognosis attributed to cases with t (2;5), it is interesting to note that the percentage of ALK1-positive cases is significantly higher in pediatric patients with coexpression of EMA, compared to adults.
  • Küçük Resim Yok
    Öğe
    Histopathological and immunohistochemical features of 32 cases of splenic B-cell lymphoma and leukemia
    (Turkiye Klinikleri, 2009) Kaçar Döger F.; Hekimgil M.; Ertan Y.; Sarsik B.; Soydan S.; Neşe N.
    Objective: Leukemias and non-Hodgkin lymphomas commonly involve the spleen or originate primarily in the spleen and then spread to other sites. Material and Methods: In this retrospective study, we examined the histopathological and immunohistochemical characteristics of 32 cases of primary or secondary splenic B-cell lymphoma and leukemia, in which the diagnosis was established according to the World Health Organization (WHO) classification. The immunohistochemical panel included ALK-1, BCL-2, BCL-6, CD3, CD5, CD10, CD20, CD21, CD23, CD30, CD43, cyclin D1, Ki-67, and TRAP. Results: There was no other nodal or extranodal disease involvement in the majority of patients diagnosed with lymphoma at the time of presentation, while cases of leukemia had undergone splenectomy for palliative purposes. The diagnoses were as follows: 11 cases of hairy cell leukemia (HCL, 34.4%), 8 cases of splenic marginal zone lymphoma (SMZL, 25%), 8 cases of diffuse large B-cell lymphoma (DLBCL, 25%) including 1 T-cell-rich B-cell lymphoma (TCRBCL), 4 cases of mantle cell lymphoma (MCL, 12.5%), and 1 prolymphocytic leukemia (PLL, 3.1%). Conclusion: Overall assessment of spleen, liver, bone marrow, and lymph node examinations and a detailed correlation of the histopathological and immunohistochemical features with the clinical findings are very helpful and usually lead to the final diagnosis in most cases of primary or secondary splenic B-cell lymphoma and leukemia. Copyright © 2009 by Türkiye Klinikleri.
  • Küçük Resim Yok
    Öğe
    The importance of staging systems for the determination of prognosis of well-differentiated thyroid cancer [Iyi diferansiye tiroid kanserlerinde evreleme sistemlerinin prognozun belirlenmesindeki yeri]
    (2013) Erol V.; Makay O.; Içöz G.; Köse T.; Ertan Y.; Yararbaş U.; Akyildiz M.; Yilmaz M.
    Objective: In this study we aimed to determine the significance of the staging systems (EORTC, De Groot, MACIS, and TNM) on the prognosis of well differentiated thyroid cancer patients who underwent surgery in our clinic. Material and Methods: This retrospective study included 181 patients who were operated between December 1995-December 2007, with diagnosis of thyroid cancer. In order to obtain data related to cancer staging, a computer program for PDA was developed to enter determined parameters easily. Survival analyses were performed. The findings were compared with the prescribed rates by the staging systems. Results: According to the De Groot staging system, stage 1 and stage 2 patients' results were compatible, stage 3 and 4 patients' results were determined to be different (stage 3; 87% versus 66.6%, stage 4; 35% versus 100%, p=0.04). In the MACIS staging system, 20-year survival rates are determined and there is insufficient follow-up period in this study for compaison. Compared to the EORTC staging system, stage 3 and stage 4 patients' results were determined different (stage 3; 51% versus 100%, stage 4; 33% versus 50%, p=0.02). The most consistent results in terms of prognosis was determined in comparison with the TNM staging system (stage 1; 100% versus 97.8%, stage 4; 45.3% versus 50%). Conclusion: Until recently, in order to be able to predict the behavior of the tumor, many classification systems were made up for well differentiated thyroid cancer. In this study, we concluded that in the determination of the prognosis of well-differentiated thyroid cancer, the TNM staging system can determine the prognosis in a manner consistent with the clinical findings. © Copyright 2013 by Turkish Surgical Association.
  • Küçük Resim Yok
    Öğe
    Incidentally found pharyngoesophageal diverticulum and parathyroid adenoma during thyroid surgery [Tiroid cerrahisi sirasinda insidental olarak saptanan paratiroid adenomu ve faringoözofageal divertikül]
    (2012) Isayev C.; Makay Ö.; Ertan Y.; Sözbilen M.; Içöz G.
    Pharyngoeosophageal diverticula are the most common type of diverticula of the eosophagus and are often encountered in the elderly. Parathyroid adenomas are the most common cause of primary hyperparathyroidism. In this case report, we present the case of a 73 year old female patient who was admitted to the endocrinology outpatient clinic in our hospital, complaining of profuse weight gain. The patient was later operated on due to the discovery of a multinodular goitre. Incidentally, the patient appeared to have a synchronous parathyroid adenoma and Zenker diverticulum, both of which were diagnosed intraoperatively. A total thyroidectomy along with excision of the adenoma and stapler-assisted diverticulectomy was performed. The patient did well during her postoperative course. To our knowledge, this is the first report in the literature of a patient that was operated on due to a multinodular goitre with synchronous parathyroid adenoma and Zenker diverticulum.
  • Küçük Resim Yok
    Öğe
    Medullary thyroid carcinoma showing melanocytic differentiation: A report of a rare case [Melanositik diferansiasyon gösteren tiroid medüller karsinomu: Nadir bir olgu sunumu]
    (Turkiye Klinikleri, 2015) Karaarslan S.; Ertan Y.; Buğdaycı M.H.; Taşlı F.; Ören D.; Akalın T.
    Medullary thyroid carcinoma (MTC) accounts for 5-10% of all thyroid malignancies. These tumors show variable morphological features; however, to the best of our knowledge, melanocytic differentiation is rare with only 11 reported cases. We report a 44-year-old female who presented to our clinic with neck swelling of a few months. The thyroid fne needle aspiration biopsy results were suspicious, leading to a total thyroidectomy. On microscopic examination, a malignant tumor with melanocytic features was seen. There was no amyloid deposition in the stroma. Immunohistochemical analysis revealed that the tumor cells were positive for calcitonin, melan-A, HMB45, pancytokeratin, chromogranin, carcinoembriyonic antigen; focal positive for S-100; and negative for HBME-1 and thyroglobulin. This tumor was diagnosed as medullary carcinoma with melanocytic differentiation when evaluated with the morphological and immunohistochemical findings. © 2015 Galenos Yayincilik, All rights reserved.
  • Küçük Resim Yok
    Öğe
    Molecular evaluation of t(14;18)(bcl-2/IgH) translocation in follicular lymphoma at diagnosis using paraffin-embedded tissue sections [Foliküler lenfoma Tani{dotless}si{dotless}nda Parafine-Gömülü Dokular kullani{dotless}larak t(14;18)(bcl-2/IgH) translokasyonun moleküler yöntemler ile Degerlendirilmesi]
    (2012) Selvi N.; Kosova B.; Hekimgil M.; Gündüz C.; Kaymaz B.T.; Karaca E.; Saydam, G..; Tombuloglu M.; Büyükkeçeci F.; Çagirgan S.; Ertan Y.; Topçuoglu N.
    Objective: Follicular lymphoma (FL) is one of the most common lymphomas, and is characterized by t(14;18) (q32;q21) in more than 80% of patients. The aim of this study was to determine the rate of t(14;18) positivity based on the detection of mbr or mcr in paraffin-embedded tissue samples. Material and Methods: The study included 32 paraffin-embedded tissue samples collected from 32 consecutive FL patients that were diagnosed and followed-up at our hospital between 1999 and 2006. The MBR breakpoint was identified based on real-time PCR using a LightCycler v.2.0 t(14;18) Quantification Kit (MBR), multiplex PCR, and seminested PCR. To identify the mcr breakpoint, real-time PCR was performed using specific primers and the FastStart DNA Master SYBR Green I Kit. To detect t(14;18) via fluorescence in situ hybridization (FISH) nuclei from paraffin-embedded tissue sections were extracted and used together with LSI IgH (immunoglobulin heavy chain) (spectrum green)/bcl-2 (B-cell leukemia-lymphoma 2) (spectrum orange) probes. Results: The DNA and nuclei isolation success rate for B5 formalin-fixed, paraffin-embedded tissue sections (n = 12) was 42% and 33%, respectively, versus 95% and 60%, respectively, for 20 tissue sections fixed in formalin only. In all, 24 paraffin-embedded tissue sections were analyzed and mbr positivity was observed in the DNA of 82.14% via seminested PCR, in 53.57% via multiplex PCR, and in 28.57% via real-time PCR. We did not detect mcr rearrangement in any of the samples. In all, 15 of 16 patients (93.75%) whose nuclei were successfully isolated were observed to be t(14;18) positive via the FISH method. Conclusion: Semi-nested PCR and FISH facilitated the genetic characterization of FL tumors. As such, FISH and PCR complement each other and are both essential for detecting t(14;18) translocation.
  • Küçük Resim Yok
    Öğe
    Multicentricity in thyroid papillary microcarcinomas [Tiroid papiller mikrokarsinomlarinda multisentrisite]
    (2010) Erol V.; Makay Ö.; Ertan Y.; Içöz G.; Akyildiz M.; Yilmaz M.; Yetkin E.
    Purpose: In this study we aimed to determine, the multcentricity rates in patients with papillary microcarcinoma and the surgical method that should be applied. Materials and Methods: A total of 1818 patients underwent thyroid surgery and we evaluated 379 patients retrospectively, who were reported to have thyroid cancer histopathologically. In these patients, 137 patients with papillary microcarcinoma were determined. We reviewed medical records of patients, for mulicentricity and frequency of microcarcinoma. Patients were classified according to MACIS, EORTC and TNM classification systems for thyroid cancer. Results: Thirty-three (24%) of 137 patients with papillary microcarcinoma were detected to be multicentric. In 7 (21%) there were two or more tumor foci. The incidence of cancer was 33% in the other lobe when there was more than one foci in the same lobe. In all patients preoperative ultrasonography of the thyroid gland was multinodular. Ultrasonographic findings suspicious for malignancy were sought and in 44% patients these findings were present. Fine needle aspiration biopsy was performed in 31 patients and results of 23 patients were benign. Frozen section was performed 58 patients, where 17 patients had a benign frozen section report. Conclusion: The risk of multicentricity in papillary microcarcinoma patients should be taken into account for determining the optimal surgical treatment. To prevent missing microcarcinoma foci, ultrasonography should be applied meticulously.
  • Küçük Resim Yok
    Öğe
    Multiple spinal metastases of cranial gliosarcoma: A case report and review of the literature
    (2008) Demirci S.; Akalin T.; Islekel S.; Ertan Y.; Anacak Y.
    Gliosarcoma is a rare brain tumor that consists of both glial and mesenchymal components. We report the case of a 68-year-old female with cranial gliosarcoma metastatic to the spinal cord. Initially, the patient was diagnosed with cranial gliosarcoma and treated with surgical resection followed by radiotherapy. Four months after she completed treatment, she presented with a sudden onset of hemiplegia. MRI (Magnetic Resonance Imaging) scan demonstrated two masses at the thoracic spinal cord. Immediate surgery was performed and the lesions were resected. No further therapy was recommended due to the poor condition of the patient. The patient subsequently died 3 months after diagnosis of the spinal cord metastases. There are about 20 reported cases of metastatic gliosarcoma and most focus on systemic metastases of gliosarcoma. Spinal cord metastases are, however, very rare and here we report such a case. Available literature on metastatic gliosarcoma was also reviewed. © Springer Science+Business Media, LLC. 2008.
  • Küçük Resim Yok
    Öğe
    Papillary Thyroid Cancer, Macrofollicular Variant: The Follow-Up and Analysis of Prognosis of 5 Patients
    (Hindawi Publishing Corporation, 2014) Erol V.; Makay Ö.; Ertan Y.; Içöz G.; Akyildiz M.; Yilmaz M.
    Objective. The main aim of this study was to comparatively analyze the recurrence and prognosis of this rare variant with the literature by analyzing the follow-up data of 5 patients diagnosed with papillary cancer macrofollicular variant. Methods. The demographic data, radiological and pathological data, and prognostic data of 5 patients who underwent surgery for thyroid cancer and were diagnosed with papillary cancer macrofollicular variant pathologically were retrospectively analyzed. Results. The mean age of patients whose mean follow-up period was determined as 7.2 years was 41, and the male/female ratio was 4/1. All patients underwent total thyroidectomy. The pathology report of 2 patients (40%) revealed macrofollicular variant of papillary microcancer, and 3 patients papillary cancer macrofollicular variant. Central dissection was performed in one patient (20%) due to macroscopic pathologic lymph node and 4 metastatic lymph nodes were reported. Also, locoregional recurrence was present in 3 out of 5 patients (60%). Conclusions. Although an impression of earlier and increased risk of recurrence in papillary carcinoma with macrofollicular variant has been documented, more studies with extensive follow-up times and large populations are required. © 2014 Varlik Erol et al.