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Öğe Caviar production from flathead grey mullet (Mugil cephalus, Lin. 1758) and the determination of its chemical composition and roe yield [Topan kefali (Mugil cephalus, L. 1758) yumurtasindan havyar eldesi, randimani ve kimyasal kompozisyonunun belirlenmesi](2002) Iengör G.F.; Cyhaner A.; Erkan N.; Özden O.; Varlik C.; Erkan N.The aim of this research is to determine the yield and chemical composition of the caviar produce from flathead grey mullet (Mugil cephalus, Lin. 1758) in the Sufa lagoon. Acording to the results of our research 21.98% of the fish with an average live weight of 1,243.63 ± 322.44 g and 49.11 ± 3.83 cm length contains with roe. Salting the caviar caused a weight loss of 35%. As a result of salting, the salt content of the product was raised to 4.61% and as a result of waxing this reached a maximum of 7.04%. In all chemical composition parameters salted and waxed caviar groups had lower moisture, higher protein, fat and ash contents when compared to raw caviar.Öğe Effects of CO 2 pneumoperitoneum on nephrotoxicity of sevoflurane: An experimental study in rabbits(2006) Bayar M.S.; Küçükgüçlü S.; Gokmen N.; Dursun Z.; Tuna E.B.; Erkan N.Background: The purpose of this study is to evaluate the nephrotoxicity of sevoflurane inhalation anesthesia applied during carbon dioxide pneumoperitoneum (CO 2-PNP) which is conducted for a laparoscopic surgery treatment. Materials and Methods: 14 New Zealand white rabbits were used in this study. Initially, anesthesia was induced using 3.7% concentrated sevoflurane + 50% O 2/N 2O. Then, a tracheotomy was performed, and the rabbits were mechanically ventilated. The first group (n = 7) was subjected to CO 2-PNP for 90 min with a constant intraabdominal pressure of 12 mm Hg, the second (control group) (n = 7) was exempted. The serum inorganic fluoride (IF -) concentration was measured. The rabbits were sacrificed after 72 h, and one kidney each was immediately extracted for histopathological examination. Results: Serum IF - concentrations were not different in both groups. Histopathologically, mild renal damage was found in one rabbit in each group. Conclusion: CO 2-PNP did not have any additional effect on the nephrotoxicity of sevoflurane. © 2006 S. Karger GmbH.Öğe Effects of selected antibiotics on pancreatitis induced liver and pulmonary injury(2005) Önek T.; Erkan N.; Zeytunlu M.; Sagol Ö.; Çoker C.; Çoker A.OBJECTIVE: To investigate the protective effect of antibiotherapy in the early phase of acute pancreatitis on cellular injury induced in lungs and liver. BACKGROUND: Cellular viability and plasma nitric oxide (NO) levels were assessed to determine the efficacy of highly bactericidal imipenem and quinolones on liver and lung injury. METHODS: Imipenem, levofloxacin or saline were administered to rats with caerulein induced pancreatitis. Twenty-four hours later serum amylase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and NO levels, pancreatic interstitial inflammation, acinar cell necrosis, acinar cell vacuolisation, peripancreatic fat necrosis; spotty necrosis, focal inflammation of liver and inflammatory processes in the lungs were assessed. RESULTS: Enzyme levels in the antibiotherapy groups were lower than in the control group. Serum NO levels were higher only in the imipenem group. Levofloxacin decreased acinar cell vacuolisation in the pancreas; interstitial edema, neutrophilic infiltration and interstitial enlargement in the lungs. Antibiotherapy decreased spotty necrosis, apoptosis and focal inflammation in the liver. CONCLUSIONS: Although treatment with imipenem is associated with higher NO levels than levofloxacin, levofloxacin prevents organ injury more effectively than imipenem in acute pancreatitis. Our results indicate that antibiotherapy in the early period of necrotizing pancreatitis prevents cellular damage induced in pancreas, liver and lungs.Öğe Extra-gastrointestinal stromal tumor of the pancreas(2011) Erkan N.; Çoker A.; Postaci H.; Cengiz Yilmaz; Elif Selek; Erdem GokerBackground: Primary pancreatic gastrointestinal stromal tumors are very rare. Here in we present a malignat extragastrointestinal tumor of the pancreas that was managed multi-disciplinarily. Case presentation: A 64 -year -old male patient presented with a several month history of progressive fatique, nausea, loss of appetite and weight loss. Physical examination revealed a large, painless and smoooth epigastric mass. Laboratory data including tumour markers were within normal limits except a mild anemia. An abdominal CT scan revealed a predominantly cystic mass with solid component that had a 22x14 cm in size originating from body of the pancreas. The patient underwent laparotomy and distal pancreatectomy, splenectomy and wedge resection over gastric wall was made. Pathology revealed a malignant extragastrointestinal tumor of the pancreas. During follow-up period of two years, metastases located on 6-7th segment of liver was detected. Patient was treated as adjuvant by imatinib mesylate. Eventhuogh that adjuvant treatment, liver metastases showed progression. Five years after the first initial diagnosis, patient was reoperated for metastatectomy and bisegmentectomy, cholecystectomy and Roux en Y hepaticojejenostomy was made Postoperative period was uneventful and adjuvant imatinib mesylate treatment (400 mg bid) was continued. During follow-up period of 34 months following second surgery, multiple hepatic metasteses were detected and he was death due to multiple organ failure 8 years after initial diagnosis. Conclusion: Although rare in the pancreas, GIST should be considered in differential diagnosis of pancreatic masses and GIST patients with liver metastases require combined multimodal management from the outset.Öğe Lipoma of the Large Intestine: A Clinicopathological Review of Six Cases(2010) Erkan N.; Çalişkan C.; Vardar E.; Yilmaz C.; Korkut M.Objectives: Symptoms of colonic lipomas generally have a silent clinical course. We presented the clinical features, treatment methods, and follow-up results of six cases with large bowel lipoma. Patients and Methods: A retrospective review of patients with a diagnosis of large bowel lipoma between January 2000 and December 2006 was conducted. Data related to presentation, diagnosis, surgical treatment and pathology were analyzed. Results: Six patients (4 men, 2 women; mean age 63 years; range 43 to 82 years) were operated on due to lipoma of large intestine. Abdominal pain was the most common presenting complaint. One of the patients was treated urgently due to colo-colonic intussusception and the others were operated in elective conditions. The endoscopic biopsies were inconclusive. The preoperative diagnosis was colonic lipoma in two patients and four patients were treated due to suspected tumor of the colon. The locations of the lesions were ascending and transverse colon in two patients, cecum and sigmoid colon in the others. Right hemicolectomy was performed in three patients, left hemicolectomy, sigmoid and segmenter colon resections were performed in the others. Histopathologic examinations of the resected materials showed submucosal lipoma of the large intestine. Postoperative period was uneventful in all of the patients. Conclusion: In large symptomatic colonic lipomas that can cause obstruction or hemorrhage, surgical treatment is needed to prevent complications and to exclude the possibility of malignancy. © Medical Journal of Trakya University. Published by Ekin Medical Publishing. All rights reserved.
