Effects of CO 2 pneumoperitoneum on nephrotoxicity of sevoflurane: An experimental study in rabbits
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The purpose of this study is to evaluate the nephrotoxicity of sevoflurane inhalation anesthesia applied during carbon dioxide pneumoperitoneum (CO 2-PNP) which is conducted for a laparoscopic surgery treatment. Materials and Methods: 14 New Zealand white rabbits were used in this study. Initially, anesthesia was induced using 3.7% concentrated sevoflurane + 50% O 2/N 2O. Then, a tracheotomy was performed, and the rabbits were mechanically ventilated. The first group (n = 7) was subjected to CO 2-PNP for 90 min with a constant intraabdominal pressure of 12 mm Hg, the second (control group) (n = 7) was exempted. The serum inorganic fluoride (IF -) concentration was measured. The rabbits were sacrificed after 72 h, and one kidney each was immediately extracted for histopathological examination. Results: Serum IF - concentrations were not different in both groups. Histopathologically, mild renal damage was found in one rabbit in each group. Conclusion: CO 2-PNP did not have any additional effect on the nephrotoxicity of sevoflurane. © 2006 S. Karger GmbH.
Açıklama
Anahtar Kelimeler
Laparoscopic surgery, Pneumoperitoneum, Rabbit, Sevoflurane
Kaynak
Chirurgische Gastroenterologie Interdisziplinar
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
22
Sayı
2
