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Öğe Autoantibody Positivity in Children with Chronic Diarrhea(2020) Tuhan, Hale; Aslan, Aslı; Ecevit, Çiğdem Ömür; Azarsız, Elif; Karaca, Neslihan Edeer; Çetin, Funda; Aksu, GüzideAim: We aimed to determine the frequency of autoantibody antinuclear (ANA), peripheral anti-neutrophil cytoplasmic antibody (p-ANCA), antisaccharomyces cerevisiae antibody (ASCA), anti-pancreatic exocrine gland antibody (PAb), goblet cell antibody (GAb) positivities in children with the complaint of chronic diarrhea and inflammatory bowel disease (IBD). We also purposed to explore the role of these autoantibodies in the differential diagnosis of IBD. Materials and Methods: In our study, serum samples of 51 patients with the complaint of chronic diarrhea and 35 healthy controls were analyzed. Clinical and laboratory data at the time of serum sampling were collected and a differential diagnosis was made as the results of performed tests were recorded. For all patients, ANA, p-ANCA, ASCA, GAb, PAb positivities were evaluated by indirect immunofluorescence. The chronic diarrhea group was divided into two groups, namely, the IBD group and non-IBD group. Results: In the chronic diarrhea group, 11 (21.6%) patients had ANA, 3 (5.9%) had p-ANCA, 1 (2%) had PAb, 1 (2%) had Gab and 1 (2%) had ASCA positivity. From the 35 cases of the control group, 8 (22.9%) had ANA, 7 (20%) had ASCA positivity. In the control group, ASCA was found to be high (p=0.007). Six cases were diagnosed as IBD; 1 (16.7%) had ANA, 1 (16.7%) had p-ANCA, 1 (2%) had Gab and 1 (2%) had ASCA positivity. ASCA and GAb positivities were significantly more frequent in the IBD group (p=0.006, p=0.006, respectively). Conclusion: ASCA was determined to be significantly higher in the control group. High positivity in the control group showed that the percentage of nonspecific positivity may be high for this test. ASCA and GAb of those patients with a diagnosis of IBD were found significantly higher. The serologic tests which depend on p-ANCA, ASCA, PAb, GAb can be supportive of diagnoses and differential diagnoses of IBD. Autoantibodies in IBD may be used as a supportive diagnostic tool in selected cases, rather than as the diagnosis of IBD as routine practice.Öğe Determination of Variables Influencing the Quality of Life in Children with Liver Transplantation(2019) Altuğ, Nursen; Ecevit, Çiğdem Ömür; Karakoyun, Miray; Taşcı, Ezgi Kiran; Bolışık, Bahire; Aydoğdu, SemaAim: This clinical study examined various dimensions of the Quality of Life (QoL) in children who had undergone liver transplantation. Materials and Methods: the patient group (n=50) of the study consisted of children and their families where the child had received a liver transplant (possibly from their mother) in Ege University Organ Transplant Research Center. the control group (n=50) consisted of children and their families who did not undergo any organ transplants, did not have any health issues and were of similar age, gender and socio-economic status with the members of the study group. the children in the study were examined with a QoL questionnaire named KINDer Lebensqualitätsfragebogen (Children’s Quality of Life Questionnaire). Results: the overall QoL and the QoL in the physical, emotional, self-esteem, family, friend, and school sub-categories as reported by the children themselves in the study group, in both the 8-12 and 13-16 year age groups were determined to be higher (p<0.05) when compared to those children in the control group. Similarly, the QoL for the children in the study group, as reported by their families were determined to be higher (p<0.05) when compared to the control group. Conclusion: Liver transplantation has effects on the QoL of both the children and their families.Öğe Familial Mediterranean Fever Mimicking Wilson’s Disease: A Case Report(2018) Turan, Caner; Karakoyun, Miray; Ecevit, Çiğdem Ömür; Barbet, Funda Yılmaz; Aydoğdu, SemaWilson’s disease (hepatolenticular degeneration) is an autosomal recessive defect in cellular copper transport. Impaired biliary copper excretion leads to an accumulation of copper mostly in the liver, brain and cornea. Familial Mediterranean Fever (FMF) is an autosomal recessive autoimmune disease as a result of a mutation in the MEFV gene encoding pyrin protein characterized by recurring fever and polyserositis attacks. in this report, we describe a Turkish female child with cholestatic hepatitis of unknown etiology who was later diagnosed with typical FMF.Öğe Validity and reliability study of the pediatric Rome III questionnaire for Turkish children and adolescents(2016) Özgenç, Funda; Kara, Aybüke Akaslan; Yılmaz, Nilüfer Demiral; Önen, Şerife Şebnem; Öğretmen, Tuncay; Ecevit, Çiğdem Ömür; Çalışkan, Süleyman AyhanBackground/Aims: Questionnaire on Pediatric Gastrointestinal Symptoms: Rome III version (QPGS-RIII), originally developed in English, was adapted to different languages in order to widen its use. the aim of this study was to evaluate the validity and reliability of a questionnaire on the Pediatric QPGS-RIII parent-report form for children and self-report form for children and adolescents, which has been adapted into Turkish.Materials and Methods: the study group comprised 7-18-year-old children/adolescents (n=690) who presented to Ege University School of Medicine, Department of Child Health and Diseases outpatient clinic. in the study, the validity and reliability of the QPGS-RIII Turkish version of the questionnaire was established.Results: Confirmatory factor analysis (CFA) resulted in a 10-factor model satisfactory construct for the validity and in acceptable indices of goodness of fit. Standardized coefficients determined with CFA in the Turkish version of the instrument ranged between 0.15 and 0.87 in the 7-9-year-old children and between 0.13 and 0.98 in the 10-18-year-old children/adolescents. t-values of all the factor loadings were significant. in addition, the test-retest analyses were above 0.70, except for the abdominal migraine factor.Conclusion: Findings relating to the validity and reliability of the study indicated that the Turkish version of the instrument could be adequately used to assess functional gastrointestinal disorders (FGIDs) in Turkish children and adolescents. the Turkish version of the instrument is therefore recommended to be used in epidemiologic studies and in clinical trials to be conducted in a Turkish-speaking populationÖğe Wilson hastalığında multimodal uyarılmış potansiyel yanıtların tanısal değeri(Ege Üniversitesi, 2011) Ecevit, Çiğdem Ömür; Yağcı, Raşit VuralGiriş: Progresif hepatolentiküler dejenerasyon olarak da bilinen Wilson Hastalığı (WH), otozomal resesif geçişli bir bozukluk olup bakırın biriktiği dokulardaki toksik etkisi sonucunda oluşan sistemik bir hastalıktır. Bulgular değişkendir ve bakırın spesifik organda birikimi ile ilişkilidir. Çocukluk yaş grubunda en sık karaciğer hastalığı görülmekle birlikte zamanla vücuttaki bakır yükü arttıkça diğer organlarda birikerek değişik klinik tablolara sebep olabilir. Başta karaciğer hastalığı şeklinde olan klinik tabloya zamanla nörolojik bulgular eklenebilir. Amaç: Bu çalışmanın amacı, WH olarak izlediğimiz ve ön planda karaciğer tutulumu olan olgularda, subklinik nörolojik tutulumun olup olmadığının multimodal uyarılmış potansiyel ölçümleri ile değerlendirilmesi ve bu verilerin karaciğer hasarının derecesi ile ilişkisinin olup olmadığının belirlenmeye çalışılmasıdır. Yöntem ve Gereçler: Çalışma grubunu Ege Üniversitesi Çocuk Gastroenteroloji, Hepatoloji ve Beslenme Ünitesi' nde Temmuz 2010 ? Aralık 2010 tarihleri arasında kontrol muayeneleri yapılan ve düzenli izlemi olan 5-18 yaş arasındaki 28 WH tanılı olgu ve aynı yaş grubunda olan fonksiyonel karın ağrısı nedeni ile izlenen 24 olgu oluşturdu. Tüm hastaların ve kontrol grubunun multimodal uyarılmış potansiyel tetkikleri olan SEP, VEP ve BAEP incelemeleri Ege Üniversitesi Nöroloji Anabilim Dalı Elektrofizyoloji Laboratuvarında gerçekleştirildi. Bulgular:. Hasta grubunun %53,5' unda en az bir anormal uyarılmış potansiyel (UP) değeri elde edildi. En az bir tarafta VEP P100'de hastaların %25' inde, BAEP'de %28,5' unda ve SEP'de %11'inde anormal değerler bulundu. Interpik latans (IPL) değerleri kontrol grubu ile karşılaştırıldığında hasta grubunun sağ VEP P100, sağ BAEP I-III IPL'ı ile sol BAEP I. dalga latanslarında istatistiksel olarak anlamlı uzama saptandı. Sonuç: Sonuç olarak, uyarılmış potansiyel incelemelerinin WH' da subklinik beyin hasarını göstergesi olarak kullanılabilecek bir tetkik olarak saptadık. Özellikle tanı anında ve tedavi altında yıllık izlemlerle elde edilecek uyarılmış potansiyel ölçümlerindeki değişikliklerin, hastalığa bağlı subklinik etkilenimi ortaya çıkarmada daha yararlı olacağını düşünmekteyiz.
