Yazar "Dogan I." seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    The effect of phenyramidol on neural development in early chicken embryo model
    (Turkish Neurosurgical Society, 2019) Ozgural O.; Bahadir B.; Dogan I.; Eroglu U.; Aktan S.; Kar I.; Unlu A.
    AIM: To investigate the effects of Phenyramidol (Phe) on neural development in an early chicken embryo model. MATERIAL and METHODS: Sixty fertile non-pathogenic Super Nick eggs were incubated for 24 hours (h) and divided into four groups of 15 eggs each. Phe was administrated through the sub-blastoderm, and the eggs were incubated for another 24 h. All eggs were opened after 48 h of incubation, and the embryos were evaluated morphologically and histopathologically. RESULTS: In Group 1 (control group), none exhibited neural tube defects (NTDs) (0%), 1 (6.6%) was undeveloped; in Group 2 (low dosages), 1 did not develop (6.6%); in Group 3 (normal dosages), 2 (13.4%) had NTDs, 1 (6.6%) was undeveloped; in Group 4 (high dosages), 5 (33.3%) had NTDs, 2 (13.3%) were undeveloped. CONCLUSION: In light of the results, it was determined that the use of increasing doses of Phe led to defects in midline closure in early chicken embryos. This is the first report in the literature on Phe used in an early chicken embryo model. © 2019, Turkish Neurosurgical Society.
  • Küçük Resim Yok
    Öğe
    Electron spin resonance and pulse radiolysis studies on the reaction of OH. and SO4 .- with five-membered heterocyclic compounds in aqueous solution
    (1990) Dogan I.; Steenken S.; Schulte-Frohlinde D.; Içli S.
    The reactions of several five-membered oxygen and nitrogen heterocyclics with OH. and SO4 .- radicals have been investigated in aqueous solution using in-situ radiolysis and photolysis ESR, and optical and conductometric pulse radiolysis techniques for detection. OH. reacts with (the saturated) oxazolidone, imidazolidinone, hydantoin, and oxazoline derivatives by hydrogen abstraction, preferentially from the carbon adjacent to the nitrogen atom. With (the unsaturated) oxazoles and isoxazoles, OH. reacts by addition to the carbon at the 5-position of the ring to produce allylic radicals. In basic and acidic solutions of oxazole a ring opening process follows the OH. addition. SO4 .- reacts with oxazoles and isoxazoles by addition to C5 yielding SO4 - adducts, whereas with imidazole, pyrazole, and pyrrole derivatives, SO4 .- gives rise to neutral, conjugated radicals with the unpaired electron delocalized over the entire ring, which are derived from the parent compounds by one-electron oxidation followed by deprotonation. In the case of N-methylimidazole, the radical cation is obtained. The absolute rate constants determined for the reaction of SO4 .- with the five-membered heteroaromatics (k = 3 × 108 to 8 × 109 M-1 s-1) reflect the electrophilicity of the SO4 .- radical. © 1990 American Chemical Society.
  • Küçük Resim Yok
    Öğe
    Incidence of cyclophosphamide-induced urotoxicity and protective effect of mesna in rheumatic diseases
    (Journal of Rheumatology, 2015) Yilmaz N.; Emmungil H.; Gucenmez S.; Ozen G.; Yildiz F.; Balkarli A.; Kimyon G.; Coskun B.N.; Dogan I.; Pamuk O.N.; Yasar S.; Cetin G.Y.; Yazici A.; Esmen S.E.; Cagatay Y.; Yilmaz S.; Cefle A.; Sayarlioglu M.; Kasifoglu T.; Karadag O.; Pehlivan Y.; Dalkilic E.; Kisacik B.; Cobankara V.; Erken E.; Direskeneli H.; Aksu K.; Yavuz S.
    Objective. To assess bladder toxicity of cyclophosphamide (CYC) and uroprotective effect of mesna in rheumatic diseases. Methods. Data of 1018 patients (725 women/293 men) treated with CYC were evaluated in this retrospective study. All of the following information was obtained: the cumulative CYC dose, route of CYC administration, duration of therapy, concomitant mesna usage, and hemorrhagic cystitis. Cox proportional hazard model was used for statistics. Results. We identified 17 patients (1.67%) with hemorrhagic cystitis and 2 patients (0.19%) with bladder cancer in 4224 patient-years. The median time for diagnosis to hemorrhagic cystitis was 10 months (4-48) and bladder cancer was 8 years (6-10.9). There were 583 patients (57.2%) who received mesna with intravenous CYC therapy. We observed similar incidence rate for hemorrhagic cystitis in both patient groups concomitantly treated with or without mesna [9/583 (1.5%) vs 8/425 (1.8%) respectively, p = 0.08]. Cumulative CYC dose (HR for 10-g increments 1.24, p < 0.001) was associated with hemorrhagic cystitis. Conclusion. Cumulative dose was the only risk factor for hemorrhagic cystitis in patients treated with CYC. No proof was obtained for the uroprotective effect of mesna in our cohort. © 2015 All rights reserved.