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Öğe Alcaptonuria in a Turkish baby [3](1997) Coker M.; Coker C.; Darcan S.; Ersoy B.; Ozyurek R.; Mavi E.[No abstract available]Öğe Amino acid neurotransmitter levels in the cerebral cortex of mice receiving imipenem/cilastatin - Lack of excitotoxicity in the central nervous system(1998) Akisu M.; Kultursay N.; Coker C.; Akisu C.; Baka M.Imipenem, a very potent carbapenem derivative beta-lactam antibiotic, has recently found a major place in the treatment of antibiotic-resistant nosocomial infections. However, a convulsive side effect is seen in 0.2-3 percent of patients. Although it is suggested that this effect is due to the inhibition of gamma-aminobutyric acid (GABA) mediated inhibitory transmission, no study has been reported so far showing its effect on the cerebral cortex free inhibitory and excitatory amino acid levels. Twenty-one male TO albino mice were divided into three equal groups and given therapeutic (40 mg/kg/day) or excessive (500 mg/kg/day) doses of imipenem/cilastatine (I/C) or saline solution intraperitoneally for 7 days. All animals in the excessive dose group showed seizure-like activity with ataxia and loss of gait. However, no differences in aspartate, glumatate, glycine or GABA levels were seen o gas chromatographic evaluation of the cerebral cortexes of all three groups of animals, which were dispatched on the 7th day. Therefore it is suggested that imipenem exerts its convulsive effect without causing any change in neurotransmitter levels of barin, possibly by effecting the neuronal receptors directly.Öğe Effect of gestational diabetes and smoking on the elemental status of the maternal fetal placental unit(1996) Coker C.; Aydin H.; Askar N.; Ersoz B.; Akercan F.Objective: This study is undertaken to investigate the effects of gestational diabetes and smoking on the elemental status of the maternal-fetal-placental unit. Methods: Concentrations of Cu, Zn, Fe, Mg and Ca are determined in placental tissue, maternal and fetal plasma and fetal red blood cell samples obtained during delivery (group 1 gestational diabetes, n = 8; group 2 smoking, n = 8; group 3 healthy controls, n = 9). The elemental analysis is performed by inductively coupled atomic emission spectrophotometry. Results: The diabetes group shows no significant differences with respect to the elemental status of maternal and fetal plasma and fetal red blood cells. The only significant variation is observed in placental Fe (p < 0.05). In the smoking group, significant decreases are determined in placental Ca (p < 0.05), maternal plasma Zn, Mg and Ca (p < 0.05), along with fetal plasma Mg (p < 0.01) and Ca (p < 0.05) levels. Conclusion: The results are indicative of variations in perinatal elemental metabolism in abnormal states of pregnancy, especially smoking, however the mechanisms underlying these alterations are yet to be elucidated.Öğe Elemental variations in preeclampsia(1996) Askar N.; Coker C.; Aydin H.H.; Ersox B.; Ates T.Objective: There are alterations in elemental metabolism due to physiological and pathological processes in pregnancy. In this study, the physiological distribution of elements between the mother and the fetus is investigated along with the variations in the elemental status of the maternal-fetal-placental unit in pregnancies complicated with preeclamptic toxemia. Methods: Cu, Zn, Fe, Mg and Ca levels in placental tissue, maternal and fetal plasma and fetal red blood cells in the healthy individuals (n = 9) and preeclamptics (n=10) are determined by inductively coupled plasma atomic emission spectrometry. Results: Within the control group, significant differences between maternal and fetal plasma have been detected with respect to Cu (p < 0.001) and Fe(p < 0.05) levels. Comparing the preeclamptics with the controls, the most marked variation is observed in Zn status with significantly decreased concentrations in maternal and fetal plasma (p < 0.05) and fetal red blood cells (p < 0.01). Significant variations are also determined for Cu in fetal red blood cells (p < 0.05), Ca in placental tissue (p < 0.01) and fetal plasma (p < 0.05). Conclusion: This study points out the disturbances in the elemental status of the maternal-fetal-placental unit in preeclampsia.Öğe Serum malondialdehyde levels in preterm and fullterm infants undergoing phototherapy [2](1998) Akisu M.; Coker C.; Tuzun S.; Yilmaz D.; Kultursay N.[No abstract available]Öğe Urinary zinc excretion and zinc status of patients with ß-thalassemia major(Humana Press, 1999) Aydinok Y.; Coker C.; Kavakli K.; Polat A.; Nisli G.; Cetiner N.; Kantar M.; Çetingül N.In this study, zinc status and urinary zinc excretion with and without desferrioxamine (DFO) infusion and the relationship between urinary zinc excretion and renal tubular dysfunction in thalassemia major (TM) patients were investigated. Forty TM patients were given four DFO infusions on alternate days over a 1-wk period prior to the transfusion. On each day that DFO was given, a 24-h urine collection initiated. DFO was omitted for 1-wk before the following transfusion and during the period four 24-h urine collections were performed. Twenty healthy children provided 24-h urine collection as controls. Blood samples were taken on each of two consecutive transfusion days of the patients and from the controls. Urinary zinc excretion was measured and plasma and red blood cell (RBC) zinc analysis were performed by inductively coupled plasma-atomic emission spectrophotometry. Urinary N-acetyl-ß-D-glucosaminidase (NAG) activity and creatinine were determined in morning urine specimens. The mean plasma zinc concentration was significantly lower in the patients not given DFO compared to the values of the patients given DFO and the control group. The mean RBC zinc concentration (µmol/g Hb) in the patients (with and without DFO) and the control group were similar. Urinary zinc excretion was significantly higher in the patients receiving DFO compared to the control group, whereas urinary zinc excretion in the patients not given DFO was not different from the controls. Urinary NAG indices (U/g Cr) were significantly higher in the patients compared to controls. Urinary zinc excretion was correlated with the urinary NAG indices.
