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Öğe Chemical composition and antimicrobial activity of the essential oils of three Anthemis species from Turkey(2009) Kurtulmus A.; Fafal T.; Mert T.; Saglam H.; Kivcak B.; Ozturk T.; Demirci B.; Baser K.H.C.[No abstract available]Öğe Chemical composition of the essential oils of Anthemis coelopoda var. Bourgaei and A. aciphylla var. aciphylla(Springer New York LLC, 2012) Mert Gonenc T.; Fafal Erdogan T.; Demirci B.; Baser K.H.C.; Kivcak B.[No abstract available]Öğe Composition of essential oils of ten centaurea L. Taxa from Turkey(2008) Karamenderes C.; Demirci B.; Baser K.H.C.Essential oils obtained by microdistillation from seven endemic Centaurea species [C. hierapolitana Boiss., C. cadmea Boiss., C. calolepis Boiss., C. cariensis Boiss. subsp. maculiceps (O. Schwarz) Wagenitz, C. cariensis Boiss. subsp. microlepis (Boiss.) Wagenitz, C. ensiformis P.H. Davis and C. reuterana Boiss. var. reuterana] and three widespread (C. cyanus L., C. depressa Bieb. and C. urvillei DC. subsp. urvillei) Centaurea L. (Asteraceae) taxa from Turkey were analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC/MS) techniques. A total of 158 different compounds were identified. Significant and quantitative differences were observed among the species. Hexadecanoic acid (19.5–33.4%) was the main constituent of C. hierapolitana, C. cadmea, C. calolepis, C. reuterana var. reuterana, C. depressa and C. urvillei subsp. urvillei oils, while carvacrol (13.0–28.4%) was the major compound in, C. cariensis subsp. microlepis, C. cariensis subsp. maculiceps, C. ensiformis and C. cyanus oils. © 2008, Taylor & Francis Group, LLC. All rights reserved.Öğe Determination of fatty acid and essential oil constituents and biological activities on ranunculus pedatus subsp. Pedatus(Chemical Publishing Co., 2014) Erdogan T.; Gonenc T.; Demirci B.; Kivçak B.; Baser K.H.C.In this study, the fatty-acid profile, essential-oil composition and cytotoxic and antioxidant activities of the aerial parts of Ranunculus pedatus Waldst. & Kit. subsp. pedatus have been examined. Linoleic acid (24.47 %) and palmitoleic acid (18.94 %) were identified as major components by GC-FID and GC/MS analysis. Unsaturated fatty acids were found in higher amounts than saturated fatty acids. The essential oil composition was also analyzed by GC and GC/MS and 29 components were characterized. Protoanemonin (14.3 %), phytol (13.7 %), ?-bisabolol (7.9 %), (Z)-3-hexenol (7.8 %) and octanol (6.7 %) were determined as the main constituents of the essential oil. Ethanol and chloroform extracts were investigated for the cytotoxic activity against PC3, HeLa and Vero human cancer cell lines and both of the extracts were found to be effective on HeLa. The IC50 values were determined as 47 and 78.4 mg/mL for methanol and chloroform extracts respectively. Antioxidant activity of chloroform and ethanol extracts were evaluated by DPPH assay. The total phenolics and flavonoid contents of the extracts were determined by Folin-Ciocalteau and aluminium chloride methods, respectively. The ethanol extract was found to possess 67.54 % DPPH inhibition. The results obtained in the antioxidant activity assay were in positive correlation with the total phenolics and flavonoid contents of the extracts.Öğe Effect of essential oils and isolated compounds from Pimpinella species on NF-?B: A target for antiinflammatory therapy(2007) Tabanca N.; Ma G.; Pasco D.S.; Bedir E.; Kirimer N.; Baser K.H.C.; Khan I.A.; Khan S.I.Pimpinella essential oils and isolated compounds were screened for their inhibitory activity against NF-?B mediated transcription in SW1353 cells. Twelve oils were effective in inhibiting NF-?B mediated transcription. Especially the roots of P. corymbosa, P. tragium and P. rhodanta showed potent activities with IC50 values of 2, 3 and 6 µg/mL, respectively. Five pure compounds, 7 (4-(2-propenyl)phenylangelate), 12 (4-(3-methyloxiranyl) phenyltiglate), 17 (4-methoxy-2-(3-methyloxiranyl)phenyl isobutyrate), 18 (4-methoxy-2-(3-methyloxiranyl)phenylangelate) and 21 (epoxy pseudoisoeugenol-2-methylbutyrate) inhibited NF-?B mediated transcription with IC50 values of 5.5, 1.2, 0.01, 3.6 and 11 µg/mL, respectively. None of the compounds were cytotoxic to mammalian cells. These findings add significant information to the pharmacological activity of Pimpinella species and their beneficial effects and use in disease prevention especially those related to inflammation. Copyright © 2007 John Wiley & Sons, Ltd.Öğe The Essential Oil Constituents of Ranunculus marginatus d'Urv. var. trachycarpus (Fisch. & Mey.), From Turkey(Har Krishan Bhalla and Sons, 2014) Erdogan T.; Demirci B.; Baser K.H.C.; Kivcak B.Abstract: The essential oil obtained by hydrodistillation from Ranunculus marginatus var. trachycarpus (Ranunculaceae) from Turkey was analyzed by GC and GC-MS. Thirty-six compounds were characterized in the oil of R. marginatus var. marginatus. Main compounds were ?-terpinyl acetate (18.9 %), phytol (11.1 %), hexadecanoic acid (10.0 %) and ß-sesquiphellandrene (8.7 %). © 2014, Har Krishan Bhalla & Sons.Öğe Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen(2004) Tabanca N.; Khan S.I.; Bedir E.; Annavarapu S.; Willett K.; Khan I.A.; Kirimer N.; Baser K.H.C.Several plants and plant-derived pure compounds, designated as phytoestrogens, have been reported to cause estrogenic effects. They have been used for alleviation of menopausal symptoms, prevention of osteoporosis, heart disease and cancer. There is an increased interest in studying phytoestrogens such as isoflavones and lignans for their use as replacements for synthetic estrogens. In this study, the estrogenic activity of essential oils of eleven Pimpinella species and the compounds isolated from these species were evaluated using the yeast estrogen screen (YES) assay. The essential oils containing (E)-anethole as major compound showed estrogenic activity in the YES assay, except for the aerial parts without fruits of P. anisetum and P. flabellifolia. The percent maximal response produced by most anethole-containing oils was 30-50%. Fruits of P. isaurica and P. peucedanifolia were estrogenic in spite of the absence or trace amount of anethole, respectively. This study indicates that the estrogenic activity of Pimpinella oils is not solely due to the presence of anethole. Components other than anethole may be responsible for contributing towards the estrogenic activity. The essential oils from different species varied in their estrogenic potencies (relative potency from 8.3 × 10 -8 to 1.2 × 10-6 compared to 17ß-estradiol) and among the different plant parts, the fruit oils of most species were estrogenic followed by the aerial parts without fruits and the root oils and their EC 50 values varied from 45 µg/mL to 650 µg/mL.Öğe Patterns of essential oil relationships in Pimpinella (Umbelliferae) based on phylogenetic relationships using nuclear and chloroplast sequences(2005) Tabanca N.; Douglas A.W.; Bedir E.; Dayan F.E.; Kirimer N.; Baser K.H.C.; Aytac Z.; Khan I.A.; Scheffler B.E.Hydro-distilled essential oils from fruits, aerial parts (without fruits) and roots of Pimpinella species native to Turkey and their phylogenetic relationships to one another were examined. Phytochemical investigation of the essential oils of 19 species resulted in isolation of 16 phenylpropanoids, four sesquiterpenes and two azulene-type norsesquiterpenes. The structures of the isolated compounds were determined primarily from 1D- and 2D-NMR experiments as well as liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry. Phylogenetic relationships among 26 species were evaluated using ITS 1, ITS 4 nuclear rDNA and psbA-trnH cpDNA sequences. In this study, significance and occurrence of phenylpropanoids, azulenes and geijerenes are discussed from a phylogenetic, chemical and biosynthetic perspective. The distribution of different classes of compounds and their putative associations with one another as per current knowledge of their biosynthetic pathways indicates that this information, in conjunction with the phylogeny, could provide valuable information regarding the presence and perhaps evolution of the different classes of compounds. Analysis of the phenylpropanoid components indicates that (E)-anethole is an obligatory intermediate of this pathway. The various Pimpinella species differ primarily in their ability to acylate anethole, suggesting that while the pathway leading to anethole is common to this genus, species differ in their enzymatic machinery leading to acylate. The relationship between azulenes and geijerenes is not as intuitive, but all Pimpinella species analysed in this study have the biochemical machinery required to synthesize these chemical classes. © NIAB 2005.Öğe Short Comunication: The essential oil composition of aerial parts of Anthemis tricolor Boiss. from Cyprus(Taylor and Francis Ltd., 2014) Karaalp C.; Erel S.B.; Nalbantsoy A.; Gücel S.; Demirci B.; Baser K.H.C.The water-distilled essential oil from the aerial parts of Anthemis tricolor Boiss. (Asteraceae), an endemic taxon from Cyprus, was analysed by GC and GC-MS. The analysis revealed 40 compounds accounting for 84.5% of the oil. Muurola-4,11-diene (20.2%), ß-caryophyllene (9.1%) and germacrene-D (5.5%) were the main compounds of A. tricolor. To the best of our knowledge, this is the first detailed study of the essential oil composition of A. tricolor collected from Cyprus. © 2014 Taylor & Francis.
