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    Constructive effect of exogenous melatonin against osteoporosis after ovariectorny in rats
    (Sci Printers & Publ Inc, 2007) Uslu, Serap; Uysal, Ayseguel; Oektem, Guelperi; Yurtseven, Mine; Tanyalcin, Tijen; Basdemir, Guelcin
    OBJECTIVE: To analyze histomorphometric, densitometric and biochemical effects of melatonin on osteoporosis in ovariectomized rats. STUDY DESIGN: Wistar rats were divided into 6 groups. Group C: control; Group I: bilateral ovariectomy (OVX); Group II. OVX + vehicle; Group III: OVX + 10 mg/kg/day melatonin WLT); Group IV. OVX + 30 mg/kg/day MLT; Group V. sham + 10 mg/kg/day MLT. Cortex, trabecula, osteoblast and osteoclast numbers were evaluated on vertebra and femur histomorphometrically. Hydroxyproline analysis was used to determine collagen content of femur and vertebrae. Bone mineral density and bone mineral content were measured. RESULTS: Trabecular thickness and trabecular area of vertebra and femur and cortical thickness of femur showed remarkable decrease after OVX, but increased after MLT treatment in the OVX+MLT groups. Following OVX, no statistically significant difference was found in number of osteoblasts or osteoclasts, trabecular number or levels of hydroxyproline after treatment with MLT. OVX caused significant decrease in bone mineral density, but treatment with MLT was unable to reverse this effect. CONCLUSION: MLT may trigger microscopic changes in bone, and time of application is critical for clinical recovery. It can be effective in helping treat postmenopausal osteoporosis. However, it is contraindicated in women who have normal-functioning ovaries.
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    The effect of radiotherapy on propylene glycol-induced cholesteatoma in rats
    (Mediterranean Soc Otology & Audiology, 2008) Ersoy, Elif; Kirazli, Tayfun; Esassolak, Mustafa; Bilgen, Cem; Basdemir, Guelcin
    OBJECTIVE: Radiotherapy has been an alternative therapy in benign pathologies with epithelial and connective tissue hyperplasia. The aim of this study was to investigate the efficacy of low dose radiotherapy in the inhibition of cholesteatoma in an experimantal cholesteatoma model in rats. MATERIAL AND METHODS: Thirty-five Wistar albino rats were used to form 3 groups: Group I (n=20; bilateral cholesteatoma induction with propylene-glycol), Group 11 (n=10; unilateral cholesteatoma induction with propylene-glycol and unilateral intratympanic saline injection), Group III (n=5, control group without injection). The effect of radiotherapy was evaluated according to the histopathological parameters. RESULTS: The results indicated that low dose radiotherapy was ineffective in the management of cholesteatoma in this histopathological study.