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Öğe Allelic frequency of the MCP-1 promoter - 2518 polymorphism in the Turkish population and in Turkish patients with juvenile rheumatoid arthritis(2007) Özyürek A.R.; Gürses D.; Ülger Z.; Levent E.; Bakiler A.R.; Berdeli A.Although genetic and environmental factors contribute to the pathogenesis of juvenile rheumathoid arthritis (JRA), the etiology and pathogenesis remain controversial. The objective of this study was to investigate genotypic and allelic frequencies of monocyte chemoattractant protein-1 (MCP-1) gene -2518 (G/A) polymorphism in the healthy Turkish population and patients with JRA. Genomic DNA was collected from 66 JRA patients and 150 healthy individuals. To evaluate the association of the -2518 (G/A) MCP-1 gene polymorphism with the outcome of JRA, we analyzed the types of JRA and the score on the childhood health assessment questionnaire (C-HAQ score). In the healthy Turkish population, the frequencies of A and G alleles were 71 and 29%, respectively. No significant difference was observed between the JRA patients and healthy subjects in the distribution allelic and genotypic frequencies of the -2518 (G/A) MCP-1 gene polymorphism (p>0.05). However, the AG genotype was found to be higher and the AA genotype was found to be lower in the patients with systemic type JRA compared to those with the other types of JRA (p=0.019). When the JRA patients were evaluated according to the C-HAQ score, we found that the -2518 (G/A) MCP-1 gene polymorphism did not relate the prognosis (p>0.05). AG genotype was found to be higher in the systemic type of JRA. The results indicate that MCP-1 gene polymorphism might slightly associate with patients with systemic JRA. Further studies are needed to elucidate the role of this polymorphism in the pathogenesis of JRA in various populations because this polymorphism has a functional significance and an ethnic difference. © Clinical Rheumatology 2006.Öğe Anomalous origin of the left coronary artery from the pulmonary artery presenting as dilated cardiomyopathy(Turkish Anaesthesiology and Intensive Care Society, 2013) Bakiler A.R.; Eliaci¸k K.; Kos¨e S.; Atay Y.Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomaly and one of the causes of myocardial ischemia. It often presents with atypical signs and symptoms, especially in childhood. In this case report, an 11-year-old girl presented with dilated cardiomyopathy in our clinic and was followed for five years. Echocardiography showed multiple left-to-right shunts on the interventricular septum, the confirmation of which was done by multi-slice computed tomography and coronary angiography. Therefore, we suggest that ALCAPA should be suspected in young patients diagnosed with dilated cardiomyopathy. © 2013 Turkish Society of Cardiology.Öğe Anti-tumor necrosis factor-alpha monoclonal antibody treatment in a case with persistent juvenile ankylosing spondylitis and inflammatory bowel disease [Jüvenil ankilozan spondilit ve enflamatuvar bagirsak hastaligi olan bir hastada anti-tümör nekrozis faktör-alfa monoklonal antikor tedavisi](2003) Öztürk C.; Genel F.; Aksu G.; Bakiler A.R.; Kütükçüler N.Juvenile ankylosing spondylitis and inflammatory bowel disease rarely develop simultaneously, and the treatment of the disease with disease-modifying antirheumatic drugs might be difficult. In this report we present an eight-year old boy with juvenile ankylosing spondylitis and inflammatory bowel disease resistant to combined therapy of antirheumatismal drugs because of its rarity in childhood. Anti-tumor necrosis factor-? monoclonal antibody administration, a new biological treatment, is discussed in view of the literature.Öğe A case of Marden-Walker syndrome with Dandy-Walker malformation(1995) Özkınay F.; Özyürek A.R.; Bakiler A.R.; Narin N.; Yüksel H.; Özkınay C.; Parlar A.; Arcasoy M.A 5-month-old girl with Marden-Walker syndrome is presented. This is a rare autosomal recessive syndrome. So far, approximately 20 cases have been described in the literature. The patient was hospitalized because of difficulty in feeding and slow spontaneous movements. Her parents were first cousins. She was diagnosed with clinical findings of growth and motor retardation, typical facial appearance, congenital heart disease, arachnodactyly, joint contractures, and a Dandy-Walker malformation on magnetic resonance imaging. Copyright © 1995, Wiley Blackwell. All rights reservedÖğe The decline of BCG immunity after neonatal vaccination: what about revaccination at one year?(1993) Aydinlioglu H.; Caglayan S.; Kansoy S.; Yaprak I.; Seckin E.; Bakiler A.R.; Aksoy S.Summary. Two hundred and nineteen healthy newborns were vaccinated with the BCG vaccine, and their immunity was checked thereafter at 3,6 and 12 months of age. We determined that 87% of tuberculin reactivity at 3 months declined to 61% at 12 months. Revaccination of nonreactive infants provided a 100% rate of reactivity. In the light of this information we propose a revision in the BCG vaccination programme in developing countries. We also found a close relationship between the tuberculin reactivity and scar formation after BCG vaccination, suggesting that a simple check of the left deltoid region for a BCG scar may give enough information about the child's immunity to tuberculosis. Copyright © 1993, Wiley Blackwell. All rights reservedÖğe The effect of adriamycin on cardiac functions in cancer patients [KANSERLI HASTALARDA ADRIAMISINE BAGLI KARDIAK ETKILENME](1995) Senrencber S.; Ozyurek R.; Narin N.; Bakiler A.R.; Parlar A.; Arcasoy M.The frequency of complications seen is increasing parallel to successful results in cancer therapy. In this study, the frequency and the early diagnostic criteria of cardiac complications due to adriamycin were investigated in 28 cases with cancer. Sixteen of the cases were boys and 12 of them were the girls, with an average age of 9.15 years. The control group consisted of five girls and five boys, with an average age was found to be 8.22 years. Electrocardiography, echocardiography, radionuclide scintigraphy, telecardiography and cardiac enzymes were used for assessing cardiac functions. In the group taking adriamycin right and left ventricular ejection fraction parameters were found to be significantly lower than in the group not taking adriamycin. In the study group left ventricular systolic time and fractional shortening values were significantly reduced regarding to the control group. In conclusion in the absence of clinical findings, myocardial effect proportional to the cumulative dose of adriamycin may be shown especially by radionuclide study. Echocardiography may not be a sensitive method for such doses.Öğe The importance of prolactin in acute rheumatic fever(1994) Narin N.; Ozyurek R.; Bakiler A.R.; Yuksel H.; Elidemir O.; Parlar A.; Arcasoy M.Prolactin is an important hormone of the endocrine system. In recent studies, it has been shown that this hormone is related to the immune system and connective tissue disease. Acute rheumatic fever (ARF) is an immunologic disease in which connective tissue is also attacked. In this serie, we investigated the impact of prolactin on ARF. For this purpose, we detected serum levels of prolactin in patients before and after treatment. As a result we found that prolactin does not show any significant changes in the active period of ARF (P > 0.05).Öğe Left ventricular diastolic abnormalities in children with ß-thalassemia major: A doopler echocardiographic study(1998) Yaprak I.; Akşit S.; Öztürk C.; Bakiler A.R.; Dorak C.; Türker M.Left ventricular filling patterns were assessed by Doppler echocardiography in 63 ß-thalassemia major patients, aged for to 21 years, with no clinical evidence of congestive heart failure and 63 age- and sex-matched normal controls. The patients with ß-thalassemla major were divided into three age groups, namely four to nine years (6.8 ± 1.5 years), 10-15 years (12.1 ± 1.6 years) and older than 15 years (17.3 ± 1.7 years). They were compared with age- and sex-matched normal controls in respects of Doopler diastolic indices. The ratio between the early and late (atrial) peaks of flow velocity was higher and peak flow velocity in late diastole was significantly lower in patients with ß-thalassemia major as compared to controls in all three age groups (p < .001). As compared with the controls, peak early diastolic flow velocity was also significantly higher in the thalassemics aged 10 to 15 years (92 ± 16 vs 80 ± 12 cm/s, P < .01) and in those older than 15 years (95 ± 16 vs 79 ± 13 cm/s, p<.001). Restrictive left ventricular diastolic abnormalities were detected in a total of 34 (54%) patients with ß-thalassemia major, whereas left ventricular systolic abnormalities were identified only eight (13%) of them. None of the patients without left ventricular diastolic abnormalities showed left ventricular systolic abnormalities. There was not any significant correlation between the hematologic parameters, such as mean serum ferritin, maximum serum ferritin and the number of blood units transfused, and left ventricular Doopler diastolic indices (p>.05). From the data presented here, we therefore conclude that left ventricular diastolic abnormalities develop in patients with ß-thalassemia major in the early phase of the disease and before the apearance of systolic abnormalities, when clinical symptoms of congestive heart failure are absent.Öğe Letter to the editor: Primary cardiac rhabdomyosarcoma [2](Wiley-Liss Inc., 2002) Aksoylar S.; Kansoy S.; Bakiler A.R.; Özer E.; Özgenç F.[No abstract available]Öğe Lymphocyte subsets and plasma IL-1 ?, IL-2, and TNF-? concentrations in acute rheumatic fever and chronic rheumatic heart disease(1995) Narin N.; Kütükçüler N.; Özyürek R.; Bakiler A.R.; Parlar A.; Arcasoy M.The distribution of CD3+, CD4+, CD8+, CD19+, CD16+, and CD25+ lymphocyte populations in peripheral blood as well as the plasma concentrations of interleukin-1 ? (IL-1 ?), and IL-2 and tumor necrosis factor ? (TNF-?) were investigated in 25 children with acute rheumatic fever (ARF) at the time of admission and after 3 months and in 15 children with chronic rheumatic heart disease (CRHD) and in 15 children with streptococcal pharyngitis (SP) in order to determine changes in lymphocyte subsets and cytokine concentrations occurring during different stages of the disease. The percentages and absolute counts of CD4+, CD16+, CD25+ cells, the ratio of CD4/CD8 and plasma concentrations of IL-1 a and IL-2 in patients with ARF were significantly higher at admission than 3 months later. These levels were also significantly higher than in patients with CRHD, SP, or normal controls. Production of IL-2 in ARF and CRHD patients directly correlated with the percentages of CD4+ and CD25+ cells. According to our results, the evidences of increased cellular immune response in ARF are increased percentages CD4+ and CD25+ cells, CD4/CD8 ratio, and increased plasma concentrations of IL-1 ? and IL-2. Furthermore, activation of cellular immune response was not present throughout all stages of rheumatic heart disease and also in SP. © 1995 Academic Press, Inc.Öğe Williams syndrome and subaortic stenosis(1993) Narin N.; Bakiler A.R.; Parlar A.; Arcasoy M.; Köprübaşsi F.[No abstract available]
