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    False negative high density lipoprotein-cholesterol in an autoimmune hepatitis patient: Case report [Otoimmün hepatitli bir olguda yanlis-negatif yüksek yogunluklu lipoprotein-kolesterol]
    (Turkiye Klinikleri, 2010) Barutçuoglu B.; Başol G.; Bozdemir A.E.; Kirdök S.; Habif S.; Bayindir O.
    False-negative high density lipoprotein-cholesterol (HDL-C) detection is a remarkable condition in clinical laboratory practice. We report an 18-year-old female who admitted to transplantation division, with cirrhotic process of autoimmune hepatitis in which polyclonal hypergammaglobulinemia negatively interfered with HDL-C. The HDL-C and immunoglobulin G (IgG) levels were measured before and after liver transplantation. The patient had high IgG with polyclonal hypergammaglobulinemia and an undetectable HDL-C before transplantation. Falsely undetectable HDL-C levels were ruled out by two easy methods: sample dilution and back calculation based on Friedewald formula. This false negative value of HDL-C was also confirmed with lipoprotein electrophoresis. One must be careful in hyperimmunglobulinemic patients when using direct homogeneous HDL-C assay. © 2010 by Türkiye Klinikleri.
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    The value of S100B protein measurement for the differential diagnosis of acute ischemic stroke in the geriatric population [Geriatrik hasta grubunda akut iskemik inme ayirici tanisinda S-100B protein ölçümünün degeri]
    (2012) Uncu A.; Kabaroglu C.; Başol G.; Barutçuoglu B.; Uncu G.; Kumral E.; Bayindir O.
    Introduction: A blood test supporting the clinical and radiological findings used for the diagnosis of acute ischemic stroke (AIS) is needed in the geriatric population. The aim was to demonstrate the value of S100B levels for the differential diagnosis of AIS. Materials and Method: 55 patients who have been diagnosed with AIS after admittance to an emergency room and 20 patients with transient ischemic attack (TIA) were enrolled. AIS diagnosis was based on a neurology consultation in agreement with laboratory and radiological findings. S100B levels were determined in fasting venous blood samples by an ELISA method. The results were expressed as median (minimum-maximum). Results: S100B levels were significantly higher in the AIS group [63.86 (50-1876) pg/ml] than the TIA group [50.14 (< 50- 87.63) pg/ml] (p= 0.001). S100B concentrations were not influenced by age, gender, body mass index or by the presence of coronary artery disease, diabetes mellitus, hyperlipidemia, cardiac arrhythmia, peripheral vascular disease, family history or cigarette smoking. The ROC analysis demonstrated that the area under the curve was 0.836 (p= 0.0001). Conclusion: S100B measurement is a rapid, simple and cost-effective analysis which may be used for the differential diagnosis of AIS in the early stages, especially in emergency and intensive care settings.