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Öğe A correlation of serum specific IgE and skin prick tests(Wiley-Blackwell Publishing, Inc, 2009) Demir, E.; Midyat, L.; Gulen, F.; Aksakal, K.; Celik, G.; Avcu, G.; Tanryverdi, S.; Tanac, R.Öğe Diagnostic Accuracy of Serum Galactomannan Assay in Children with Acute Myeloid Leukemia: Effect of the Revised EORTC/ MSGERC 2020 Criteria(Turkish Society of Hematology, 2023) Avcu, G.; Karadaş, N.; Göktepe, Ş.Ö.; Metin, D.Y.; Karapınar, D.Y.[No abstract available]Öğe Effects of air pollution on airway hyperresponsiveness in children (a multi-center study)(Wiley-Blackwell Publishing, Inc, 2009) Demir, E.; Midyat, L.; Can, D.; Kanyk, A.; Uzuner, N.; Avcu, G.; Tanryverdi, S.; Guelen, F.; Aksu, N.; Olmez, D.; Asilsoy, S.; Karaman, O.; Babayigit, A.; Tuncel, T.; Celik, G.; Saz, E.; Tanac, R.Öğe Evaluation of candidemia in children at a university hospital: A retrospective cohort(John Wiley and Sons Inc, 2023) Guner Ozenen, G.; Sahbudak Bal, Z.; Avcu, G.; Ozkaya Yazici, P.; Karakoyun, M.; Metin, D.Y.; Hilmioglu Polat, S.Background: Candidemia is a life-threatening infection in hospitalied children. This study aimed to evaluate candidemia's demographic and clinical characteristics and identify the risk factors and outcomes of Candida albicans (CA) and non-albicans Candida (NAC) spp. Methods: A retrospective cohort was designed to evaluate paediatric patients with candidemia between January 2008 and December 2020. Results: A total of 342 episodes in 311 patients were evaluated. The median age of the patients was 2.1 years (1 month–17 years and 6 months), and 59.6% were male. The prevalence of NAC (67.5%) candidemia was higher than that of CA (32.5%). The most commonly isolated Candida species was Candida parapsilosis (43.3%), followed by C. albicans (32.5%), Candida glabrata (6.1%) and Candida tropicalis (5.0%). The length of hospital stay prior to the positive culture and the total length of hospital stay were longer in the NAC group (p =.003 and p =.006). The neutrophil count was lower in the NAC group (p =.007). In the multivariate analysis, total parenteral nutrition, antifungal prophylaxis and a history of coagulase-negative staphylococci (CoNS) culture positivity in the past month were risk factors for developing candidemia due to NAC (p values were.003,.003 and.045). C. albicans and C. parapsilosis fluconazole resistance were 9.5% and 46.6%, respectively. The rates of amphotericin B resistance were 1.1% and 7.6% in C. albicans and C. parapsilosis, respectively. Mortality (14-day and 30-day) rates did not differ between the groups. Conclusions: A history of CoNS culture positivity in the past month, total parenteral nutrition, and antifungal prophylaxis increases the risk of NAC candidemia. © 2023 Wiley-VCH GmbH.Öğe Invasive Fungal Infections in Children With Acute Myeloid Leukemia: A Single-center Experience Over 19 Years(Lippincott Williams and Wilkins, 2023) Avcu, G.; Karadas, N.; Goktepe, S.O.; Bal, Z.S.; Metin, D.Y.; Polat, S.H.; Aydinok, Y.Objective: Invasive fungal infections (IFIs) remain a significant cause of morbidity and mortality in children with acute myeloid leukemia (AML). This study aimed to evaluate the incidence, risk factors, etiology, and outcome of IFIs in children with AML and the effect of mold-active antifungal prophylaxis. Materials and Methods: We retrospectively reviewed pediatric patients treated for AML between January 2004 and December 2022. Proven, probable, or possible IFIs were defined using standardized definitions of the European Organization for the Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) classification published at 2008. Results: A total of 298 febrile neutropenia episodes from 78 patients were evaluated. Proven, probable, and possible IFI rates were 3%, 2.6%, and 9.4%, respectively. Profound neutropenia was detected in 18 (58%) and prolonged neutropenia in 20 (64.5%) of the IFI episodes. Invasive aspergillosis accounted for the majority of IFI episodes; however, non-albicans Candida spp. were the most isolated pathogens in the proven group. Patients with relapsed AML were particularly at risk for the development of IFI (P=0.02). A significant decrease in IFI episodes was achieved with mold-active antifungal prophylaxis with voriconazole (P=0.01, odds ratio: 0.288, %95 CI:0.104-0.797). The overall mortality was 35.8%, and the IFI-attributable mortality rate was 25%. In the multivariate analysis, relapsed disease was the most significant risk factor associated with mortality (P=0.006, odds ratio:4.745; 95% CI: 1.573-14.316). Conclusion: Mold-active prophylaxis reduced the rate of IFIs in this cohort however IFI-related mortality was still high as 25% in pediatric AML patients. Relapsed AML was the most significant risk factor associated with mortality. © 2023 Lippincott Williams and Wilkins. All rights reserved.
