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Öğe Adjunctive low-dose doxycycline therapy effect on clinical parameters and gingival crevicular fluid tissue plasminogen activator levels in chronic periodontitis(Birkhauser Verlag Ag, 2006) Emingil, G.; Gurkan, A.; Atilla, G.; Berdeli, A.; Cmarcik, S.Objective and design: The present study examined effectiveness of low-dose doxycycline (LDD) in combination with nonsurgical therapy on gingival crevicular fluid (GCF) tissue plasminogen activator (t-PA) levels and clinical parameters in chronic periodontitis (CP) a over 12-month period. Methods: GCF samples were collected, probing depth (PD), clinical attachment level (CAL), gingival index (GI) and plaque index were recorded at baseline, 3, 6, 9 and 12 months. CP patients (n=65) were randomized to LDD or placebo groups. LDD group received LDD (20mg) b.i.d for 3-months plus scaling and root planing (SRP), while placebo group was given placebo capsules b.i.d for 3-months plus SRP. GCF t-PA levels were determined by ELISA. Friedman, Wilcoxon and Mann-Whitney test was used for statistical analysis. Results: Significant improvement was observed in all clinical parameters in both groups over 12-month period (p < 0.01). LDD group had lower PD, CAL and GI scores than placebo group at 6, 9 and 12-months (p < 0.05). GCF t-PA levels reduced in both groups over 12-month period (p < 0.01). LDD group had lower GCF t-PA levels than placebo group at 6 and 9-months (p < 0.05). Conclusions: These results provide additional information about usefulness of LDD therapy as an adjunct to nonsurgical therapy in long-term management of periodontitis.Öğe Antimicrobial peptide hCAP-18/LL-37 protein and mRNA expressions in different periodontal diseases(Wiley-Blackwell, 2011) Turkoglu, O.; Kandiloglu, G.; Berdeli, A.; Emingil, G.; Atilla, G.Objective: To investigate the levels of antimicrobial peptide hCAP-18/LL-37 protein and mRNA expression in gingival tissues with different periodontal disease. Materials and methods: Ten patients with generalized aggressive periodontitis, 10 patients with chronic periodontitis, and 10 healthy controls were included in this study. Periodontal parameters including probing depth, clinical attachment level, plaque index, and papilla bleeding index were assessed in study subjects. hCAP-18/LL-37 mRNA analysis by RT-PCR and immunohistochemistry were performed in 19 samples provided enough RNA in terms of concentration and integrity. Results: This study demonstrated that hCAP-18/LL-37 was a product of neutrophils. Tissue samples of chronic periodontitis patients had significantly higher immunostaining of hCAP-18/LL-37 on neutrophils infiltrating in both epithelium and connective tissue compared with controls. hCAP-18/LL-37 mRNA expression levels in tissue samples of chronic periodontitis patients seemed to be upregulated compared with controls. While two generalized aggressive periodontitis patients showed downregulated hCAP-18/LL-37 mRNA expression levels, one generalized aggressive periodontitis patient showed slightly increased hCAP-18/LL-37 mRNA level compared with controls. Conclusions: hCAP-18/LL-37 has an important role in innate response during periodontal inflammation. Local deficiency in hCAP-18/LL-37 might be a confounding effect in the pathogenesis of generalized aggressive periodontitis.Öğe Cytokine (interleukin-1beta) and MMP levels in gingival crevicular fluid after use of platelet-rich fibrin or connective tissue graft in the treatment of localized gingival recessions(Wiley, 2016) Eren, G.; Tervahartiala, T.; Sorsa, T.; Atilla, G.Background and ObjectiveThe objective of this study was to evaluate the levels of MMP-8, MMP-9, TIMP-1 and interleukin-1beta (IL-1) in gingival crevicular fluid during the early and late stages of healing in gingival recession sites treated with coronally advanced flap plus platelet-rich fibrin (CAF+PRF) compared with CAF plus connective tissue graft (CAF+CTG). Material and MethodsTwenty-four nonsmoking patients with Miller Class I or Class II localized gingival recession defects in bilateral sites received treatment with either CAF+PRF (PRF group) or CAF+CTG (CTG group). Gingival crevicular fluid samples were collected at baseline and at 10d and 1mo, 3mo and 6mo after surgery. The levels of MMP-8, MMP-9, TIMP-1 and IL-1 in gingival crevicular fluid were measured using a time-resolved immunofluorometric assay and ELISAs. ResultsGingival crevicular fluid levels of IL-1 were significantly elevated in the CTG group at 10d compared with baseline (p<0.05). At 10d after surgery, the levels of TIMP-1 in gingival crevicular fluid showed a significant decrease in the CTG group compared with the PRF group (p<0.05). The levels of IL-1 and MMP-8 in gingival crevicular fluid were significantly lower in the PRF group than in the CTG group at 10d (p<0.05). No significant differences were found in all clinical and biochemical parameters at 1, 3, and 6mo between study groups (p>0.05). ConclusionRoot coverage with CAF+PRF has a significant effect on increasing gingival crevicular fluid TIMP-1 levels and suppressing gingival crevicular fluid MMP-8 and IL- levels at 10d. Gingival crevicular fluid levels of MMP-8, MMP-9, TIMP-1 and IL-1 did not seem to be affected by the technique at later phases of wound healing.Öğe Differential expression of receptor activator of nuclear factor-kappa B ligand and osteoprotegerin mRNA in periodontal diseases(Wiley, 2007) Bostanci, N.; Ilgenli, T.; Emingil, G.; Afacan, B.; Han, B.; Toz, H.; Berdeli, A.; Atilla, G.; McKay, I. J.; Hughes, F. J.; Belibasakis, G. N.Background and Objective: Receptor activator of nuclear factor-kappa B ligand (RANKL) is responsible for the induction of osteoclastogenesis and bone resorption, whereas its decoy receptor, osteoprotegerin, can directly block this action. Because this dyad of cytokines is crucial for regulating the bone remodelling process, imbalances in their expression may cause a switch from the physiological state to enhanced bone resorption or formation. This study investigated the mRNA expression of RANKL and osteoprotegerin, as well as their relative ratio, in the gingival tissues of patients with various forms of periodontal diseases. Material and Methods: Gingival tissue was obtained from nine healthy subjects and 41 patients, who had gingivitis, chronic periodontitis, generalized aggressive periodontitis, and chronic periodontitis and were receiving immunosuppressant therapy. Quantitative real- time polymerase chain reaction was employed to evaluate the mRNA expression of RANKL and osteoprotegerin in these tissues. Results: Compared with healthy individuals, patients in all periodontitis groups, but not those with gingivitis, exhibited stronger RANKL expression and a higher relative RANKL/osteoprotegerin ratio. In addition, osteoprotegerin expression was weaker in patients with chronic periodontitis. When patients with generalized aggressive periodontitis and chronic periodontitis were compared, the former exhibited stronger RANKL expression, whereas the latter exhibited weaker osteoprotegerin expression, and there was no difference in their relative ratio. When chronic periodontitis patients were compared with chronic periodontitis patients receiving immunosuppressant therapy, osteoprotegerin, but not RANKL, expression was stronger in the latter. Conclusion: This study demonstrates that RANKL and osteoprotegerin expression are differentially regulated in various forms of periodontitis, and the relative RANKL/osteoprotegerin ratio appears to be indicative of disease occurrence. This information may confer diagnostic and therapeutic value in periodontitis.Öğe The effect of adjunctive chlorhexidine mouthrinse on clinical parameters and gingival crevicular fluid cytokine levels in untreated plaque-associated gingivitis(Springer Basel Ag, 2009) Turkoglu, O.; Becerik, S.; Emingil, G.; Kutukculer, N.; Baylas, H.; Atilla, G.To examine the effectiveness of chlorhexidine mouthrinse (CHX) in addition to daily plaque control on gingival inflammation. Fifty gingivitis patients were randomized to CHX or placebo groups. In addition to proper plaque control, CHX group rinsed with CHX, while placebo group rinsed with placebo mouthrinse for 4 weeks. Gingival crevicular fluid (GCF) samples were collected and clinical parameters including plaque index (PI), papillary bleeding index (PBI), calculus index and probing depth (PD) were recorded at baseline and repeated at 4 week. GCF IL-1 alpha, IL-1 beta, IL-1Ra, and IL-8 levels were determined by ELISA. Whole mouth clinical parameters were significantly improved in both groups at 4 weeks. CHX group showed greater reduction in the mean PI scores than placebo at 4 weeks (p < 0.05). GCF IL-8 levels of anterior sites significantly reduced in CHX and placebo group at 4 weeks (p < 0.05). GCF IL-1 alpha, IL-1 beta, IL-1Ra levels remained unchanged at 4 weeks in both groups. GCF cytokine levels of CHX group were similar to those of placebo at 4 weeks. Within the limitations of this study, CHX mouthrinse as adjuncts to daily plaque control could be useful in management of plaque-associated gingivitis, although ineffective on GCF cytokine levels.Öğe The effect of adjunctive low-dose doxycycline therapy on clinical periodontal parameters and crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis.(Int Amer Assoc Dental Researchi A D R/A A D R, 2003) Emingil, G.; Atilla, G.; Sorsa, T.; Luoto, H.; Kyrylmaz, L.; Baylas, H.Öğe The effect of adjunctive low-dose doxycycline therapy on clinical periodontal parameters and crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis.(Int Amer Assoc Dental Researchi A D R/A A D R, 2003) Emingil, G.; Atilla, G.; Sorsa, T.; Luoto, H.; Kyrylmaz, L.; Baylas, H.Öğe Effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis(Wiley, 2012) Emingil, G.; Han, B.; Ozdemir, G.; Tervahartiala, T.; Vural, C.; Atilla, G.; Baylas, H.; Sorsa, T.Emingil G, Han B, ozdemir G, Tervahartiala T, Vural C, Atilla G, Baylas H, Sorsa T. The effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis. J Periodont Res 2012; 47: 729739. (c) 2012 John Wiley & Sons A/S Background and Objective: To study the effectiveness of azithromycin in combination with nonsurgical periodontal therapy on clinical and microbiological parameters, and on the MMP-8 and TIMP-1 levels in gingival crevicular fluid, over a 6-mo time-period in patients with generalized aggressive periodontitis. Material and Methods: Thirty-two patients with generalized aggressive periodontitis were included in this randomized, double-blind, placebo-controlled, parallel-arm study. They were randomly assigned to azithromycin or placebo groups (500 mg once daily for 3 d). Probing depth, clinical attachment levels, presence of bleeding on probing and plaque were recorded. Gingival crevicular fluid samples were obtained from one single-rooted tooth, while microbiological samples were obtained from two single-rooted teeth, all with a probing depth of = 6 mm. Microbiological parameters were analyzed by quantitative real-time PCR for Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium nucleatum, Prevotella intermedia and total bacteria. Gingival crevicular fluid biomarkers were determined by immunofluorometric assay and ELISA. Results: All clinical parameters improved, and microbiological parameters and gingival crevicular fluid MMP-8 levels significantly decreased, over the 6-mo period (p < 0.05); both groups demonstrated similar improvements. The azithromycin group presented a higher percentage of deep pockets resolved (probing depth reduction of = 3 mm from baseline) compared with the placebo group at 1 mo (p < 0.05). Conclusion: Adjunctive azithromycin therapy provides no additional benefit over nonsurgical periodontal treatment on clinical parameters, microbiological parameters and gingival crevicular fluid biochemical markers investigated in patients with generalized aggressive periodontitis.Öğe Effect of various demineralizing agents on mineral contents of cementum surfaces (an electron probe analysis)(1996) Atilla, G.; Baylas, H.Hastalıklı kök yüzeylerine, kök yüzeyi düzleş-tirmesi işleminden sonra çeşitli demineralizan ajanların uygulanmasının kök yüzeyi morfolojisi ve yüzey element içeriği yönündeki etkileri elek¬tron prob cihazı kullanılarak değerlendirilmiştir. Sitrik asit ve minosiklin HCL uygulanan sement yüzeylerinin Ca ve P içeriği sağlıklı sement yüzeyine göre yüksek bulunmuştur. Tetrasiklin HCL uygulanan sement yüzeylerinin Ca ve Piçerikleri ise sağlıklı sement yüzeyi içeriğine ben¬zer bulunmuştur. Yüzey morfolojisi ile ilgili bul¬gularımız ise tetrasiklin HCL ve minosiklin HCL'e oranla daha kuvvetli asit olan sitrik asidin diğer iki ajandan daha iyi yüzey demineralizasy-onunu gerçekleştirdiğini ortaya koymuştur. Kanımızca sement yüzeyi morfolojisine ve yüzey element içeriğine adı geçen demineralizan ajan¬ların etkilerindeki bu farklılık, kök yüzeyi düzleştirmesi ile hipermineralize hastalıklı sementin tamamen kaldırılıp kaldırılamamasına ve kaldırılan miktarı değerlendirecek kriterin olmamasına bağlıdır. Bulgularımız, periodontal hastalıklı sement yüzeylerine kimyasal ajanların uygulanmasından önce asıl önemli olanın, patolojik değişikliğe uğrayan sement tabakasının kaldırılması olduğunu ortaya koymuştur.Öğe Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis(John Wiley & Sons Ltd, 2006) Kantarci, A.; Black, S. A.; Xydas, C. E.; Murawel, P.; Uchida, Y.; Yucekal-Tuncer, B.; Atilla, G.; Emingil, G.; Uzel, M. I.; Lee, A.; Firatli, E.; Sheff, M.; Hasturk, H.; Van Dyke, T. E.; Trackman, P. C.Gingival overgrowth is a side effect of certain medications and occurs in non-drug-induced School of Dental Medicine, 700 Albany Street induced forms either as inherited (human gingival fibromatosis) or idiopathic gingival overgrowth. The most fibrotic drug-induced lesions develop in response to therapy with phenytoin; the least fibrotic lesions are caused by cyclosporin A; and intermediate fibrosis occurs in nifedipine-induced gingival overgrowth. Connective tissue growth factor (CTGF/CCN2) expression is positively related to the degree of fibrosis in these tissues. The present study has investigated the hypothesis that CTGF/CCN2 is expressed in human gingival fibromatosis tissues and contributes to this form of non-drug-induced gingival overgrowth. Histopathology/immunohistochemistry studies showed that human gingival fibromatosis lesions are highly fibrotic, similar to phenytoin-induced lesions. Connective tissue CTGF/CCN2 levels were equivalent to the expression in phenytoin-induced gingival overgrowth. The additional novel observation was made that CTGF/CCN2 is highly expressed in the epithelium of fibrotic gingival tissues. This finding was confirmed by in situ hybridization. Real-time polymerase chain reaction (PCR) analyses of RNA extracted from drug-induced gingival overgrowth tissues for CTGF/CCN2 were fully consistent with these findings. Finally, normal primary gingival epithelial cell cultures were analysed for basal and ktransforming growth factor beta 1 (TGF-beta 1) or lysophosphatidic acid-stimulated CTGF/CCN2 expression at protein and RNA levels. These data indicate that fibrotic human gingival tissues express CTGF/CCN2 in both the epithelium and connective tissues; that cultured gingival epithelial cells express CTGF/CCN2; and that lysophosphatidic acid further stimulates CTGF/CCN2 expression. These findings suggest that interactions between epithelial and connective tissues could contribute to gingival fibrosis. Copyright (c) 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.Öğe Expression and regulation of the NALP3 inflammasome complex in periodontal diseases(Wiley, 2009) Bostanci, N.; Emingil, G.; Saygan, B.; Turkoglu, O.; Atilla, G.; Curtis, M. A.; Belibasakis, G. N.Periodontitis is an infectious process characterized by inflammation affecting the supporting structures of the teeth. Porphyromonas gingivalis is a major oral bacterial species implicated in the pathogenesis of periodontitis. Processing of interleukin (IL)-1 family cytokines is regulated by an intracellular innate immune response system, known as the NALP3 [nacht domain-, leucine-rich repeat-, and pyrin domain (PYD)-containing protein 3] inflammasome complex. The aim of the present study was to investigate by quantitative real-time polymerase chain reaction (PCR) the mRNA expression of NALP3, its effector molecule apoptosis associated speck-like protein (ASC), its putative antagonist NLRP2 (NLR family, PYD-containing protein 2), IL-1 beta and IL-18 (i) in gingival tissues from patients with gingivitis (n = 10), chronic periodontitis (n = 18), generalized aggressive periodontitis (n = 20), as well as in healthy subjects (n = 20), (ii) in vitro in a human monocytic cell line (Mono-Mac-6), in response to P. gingivalis challenge for 6 h. The clinical data indicate that NALP3 and NLRP2, but not ASC, are expressed at significantly higher levels in the three forms of inflammatory periodontal disease compared to health. Furthermore, a positive correlation was revealed between NALP3 and IL-1 beta or IL-18 expression levels in these tissues. The in vitro data demonstrate that P. gingivalis deregulates the NALP3 inflammasome complex in Mono-Mac-6 cells by enhancing NALP3 and down-regulating NLRP2 and ASC expression. In conclusion, this study reveals a role for the NALP3 inflammasome complex in inflammatory periodontal disease, and provides a mechanistic insight to the host immune responses involved in the pathogenesis of the disease by demonstrating the modulation of this cytokine-signalling pathway by bacterial challenge.Öğe Expression and regulation of the NALP3 inflammasome complex in periodontal diseases(Wiley, 2009) Bostanci, N.; Emingil, G.; Saygan, B.; Turkoglu, O.; Atilla, G.; Curtis, M. A.; Belibasakis, G. N.Periodontitis is an infectious process characterized by inflammation affecting the supporting structures of the teeth. Porphyromonas gingivalis is a major oral bacterial species implicated in the pathogenesis of periodontitis. Processing of interleukin (IL)-1 family cytokines is regulated by an intracellular innate immune response system, known as the NALP3 [nacht domain-, leucine-rich repeat-, and pyrin domain (PYD)-containing protein 3] inflammasome complex. The aim of the present study was to investigate by quantitative real-time polymerase chain reaction (PCR) the mRNA expression of NALP3, its effector molecule apoptosis associated speck-like protein (ASC), its putative antagonist NLRP2 (NLR family, PYD-containing protein 2), IL-1 beta and IL-18 (i) in gingival tissues from patients with gingivitis (n = 10), chronic periodontitis (n = 18), generalized aggressive periodontitis (n = 20), as well as in healthy subjects (n = 20), (ii) in vitro in a human monocytic cell line (Mono-Mac-6), in response to P. gingivalis challenge for 6 h. The clinical data indicate that NALP3 and NLRP2, but not ASC, are expressed at significantly higher levels in the three forms of inflammatory periodontal disease compared to health. Furthermore, a positive correlation was revealed between NALP3 and IL-1 beta or IL-18 expression levels in these tissues. The in vitro data demonstrate that P. gingivalis deregulates the NALP3 inflammasome complex in Mono-Mac-6 cells by enhancing NALP3 and down-regulating NLRP2 and ASC expression. In conclusion, this study reveals a role for the NALP3 inflammasome complex in inflammatory periodontal disease, and provides a mechanistic insight to the host immune responses involved in the pathogenesis of the disease by demonstrating the modulation of this cytokine-signalling pathway by bacterial challenge.Öğe Gingival crevicular fluid can degrade Emdogain and inhibit Emdogain-induced proliferation of periodontal ligament fibroblasts(Wiley-Blackwell, 2010) Laaksonen, M.; Salo, T.; Vardar-Sengul, S.; Atilla, G.; Saygan, B. Han; Simmer, J. P.; Baylas, H.; Sorsa, T.Background and Objective: Emdogain (R) (EMD), consisting mostly of amelogenin, is used in periodontal therapy to regenerate lost connective tissue. Emdogain is applied onto periodontally affected root surfaces, where it becomes exposed to proteolytic enzymes. In this study, we aimed to find out whether gingival crevicular fluid or matrix metalloproteinases (MMPs) could degrade EMD, and whether this degradation has consequences for in vitro cell proliferation. Material and Methods: We studied the effects of 156 gingival crevicular fluid samples collected from subjects with different stages of periodontal disease and from healthy control subjects and the effects of MMP-1, -2, -8, -9, -13 and -14 on the degradation of EMD using EMD-embedded zymography. The effects of gingival crevicular fluid with or without EMD and the effects of amelogenin on the proliferation of cultured periodontal ligament fibroblasts were studied by cell proliferation enzyme-linked immunosorbent assay kit. Results: Degradation of Emdogain induced by gingival crevicular fluid was greater in samples from all stages of periodontal diseases compared with healthy control samples. Of the MMPs studied, only MMP-2 and MMP-8 showed limited EMD-degrading activities. One hundred micrograms per millilitre of EMD increased proliferation of periodontal ligament fibroblasts on average by 24% (confidence interval 0.60-0.64) and at 200 mu g/mL by 30% (confidence interval 0.62-0.68) compared with control fibroblasts (confidence interval 0.48-0.52). However, gingival crevicular fluid (10 mu g/mL) together with 100 mu g/mL EMD induced the proliferation only by 6% (confidence interval 0.51-0.55) and with 200 mu g/mL EMD by 12% (confidence interval 0.54-0.58). Amelogenin at 200 mu g/mL decreased the proliferation of periodontal ligament fibroblasts by 54% (confidence interval 0.22-0.25). Conclusion: We suggest that diseased gingival crevicular fluid containing various proteases leads to degradation of EMD and decreased proliferation of periodontal ligament fibroblasts.Öğe Gingival crevicular fluid matrix metalloproteinase-13 levels and molecular forms in various types of periodontal diseases(Wiley, 2006) Ilgenli, T.; Vardar-Sengul, S.; Gurkan, A.; Sorsa, T.; Stackelberg, S.; Kose, T.; Atilla, G.BACKGROUND: The purpose of this study was to evaluate the levels, molecular forms and activation degree of matrix metalloproteinase-13 (MMP-13) in the gingival crevicular fluid (GCF) of patients with periodontal diseases and to correlate these findings with periodontal clinical parameters. METHODS: Sixty one subjects participated in this study as healthy (n = 18), gingivitis (n = 17), aggressive periodontitis (AgP; n = 15) and chronic periodontitis (CP; n = 11) groups. Clinical measurements and GCF samples were obtained from each subject. The molecular forms of MMP-13 in GCF samples were analyzed by Western immunoblotting method. Differences among the groups were assessed using non-parametric statistical analysis. RESULTS: In the CP group, levels of 29-30 kDa fragment of MMP-13, total MMP-13, and activated form of MMP-13 were significantly higher than in the healthy, gingivitis and AgP groups. GCF levels of all molecular forms of MMP-13 in AgP group were similar to those of healthy and gingivitis groups. Total and activated MMP-13 levels were positively correlated with all clinical parameters. 29-30 kDa fragment levels of MMP-13 were also positively correlated with papillary bleeding index and plaque index. CONCLUSION: These results indicate that elevated GCF MMP-13 levels may play an important role in the pathogenesis of CP. These data demonstrate, for the first time, pathologically activated and elevated MMP-13 in GCF.Öğe In vitro accuracy and reproducibility of two different manual probes.(Int Amer Assoc Dental Researchi A D R/A A D R, 2003) Buduneli, E.; Aksoy, O.; Kose, T.; Atilla, G.Öğe In vitro accuracy and reproducibility of two different manual probes.(Int Amer Assoc Dental Researchi A D R/A A D R, 2003) Buduneli, E.; Aksoy, O.; Kose, T.; Atilla, G.Öğe Plasminogen activator inhibitors type 1 and type 2 in gingival crevicular fluid of cyclosporin-a-treated patients.(Int Amer Assoc Dental Researchi A D R/A A D R, 2003) Buduneli, N.; Buduneli, E.; Cinar, S.; Atilla, G.; Lappin, D.; Kinane, D. F.Öğe Plasminogen activator inhibitors type 1 and type 2 in gingival crevicular fluid of cyclosporin-a-treated patients.(Int Amer Assoc Dental Researchi A D R/A A D R, 2003) Buduneli, N.; Buduneli, E.; Cinar, S.; Atilla, G.; Lappin, D.; Kinane, D. F.Öğe Total proteoglycan and chondroitin-4-sulphate levels in specific periodontal diseases.(Int Amer Assoc Dental Researchi A D R/A A D R, 2003) Vardar, S.; Baylas, H.; Zihnioglu, F.; Emingil, G.; Buduneli, N.; Atilla, G.Öğe Total proteoglycan and chondroitin-4-sulphate levels in specific periodontal diseases.(Int Amer Assoc Dental Researchi A D R/A A D R, 2003) Vardar, S.; Baylas, H.; Zihnioglu, F.; Emingil, G.; Buduneli, N.; Atilla, G.
