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    99mTc-exorphin-glucuronide in tumor diagnosis: Preparation and biodistribution studies in rats
    (2006) Ertay T.; Ünak P.; Özdogan O.; Biber F.Z.; Zihnioglu F.; Medine E.I.; Durak H.
    A glucuronide derivative of exorphin C called exorphin C glucuronide was obtained by enzymatic synthesis and labeled with 99mTc using glucoheptonate (GH) as bifunctional chelating agent. Labeling efficiency was 99.7±0.03%. Biodistribution studies were performed on normal and mammary tumor bearing albino Wistar rats. In addition, scintigraphic imaging with 99mTc-GH-exorphin C glucuronide (99mTc-GEG) was performed. The radiopeptide-glucuronide is rapidly cleared via the urinary system showing lower liver uptake. Results demonstrated that 99mTc-GEG can be used as a vehicle to target tumors. © 2006 Akadémiai Kiadó.
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    Nutrition and cardiovascular health: 2015 American dietary guidelines advisory report [Beslenme ve kardiyovasküler saglik: 2015 Amerikan diyet kilavuzu önerileri]
    (Turkish Society of Cardiology, 2015) Kayikçioglu M.; Özdogan O.
    [No abstract available]
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    Serum N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) and homocysteine levels in type 2 diabetic patients with asymptomatic left ventricular diastolic dysfunction
    (2010) Görmüş U.; Özmen D.; Özmen B.; Parildar Z.; Özdogan O.; Mutaf I.; Bayindir O.
    Aims: : The aim of this study was to determine serum NT-proBNP and plasma Hcy levels and to explore the relationship between serum NT-proBNP and plasma Hcy levels in type 2 diabetic patients with and without asymptomatic LVDD. Methods: : NT-proBNP and Hcy levels were measured 31 patients with type 2 diabetes mellitus. According to echocardiographic data, diabetic patients were divided into two groups: normal LV function or LV diastolic dysfunction. Results: : Serum NT-proBNP levels in diabetic patients with LVDD were significantly higher than in diabetic patients with normal LV function and controls. The area under the receiver-operating characteristic (ROC) curve for NT-proBNP to separate normal vs. diastolic dysfunction was 0.96 in type 2 diabetic patients. Plasma Hcy levels were significantly higher in both diabetic groups than in controls. Positive correlation was noted between NT-proBNP and Hcy levels in diabetic patients with LVDD (r = 0.881, p = 0.0001). Conclusions: : The correlation between elevated NT-proBNP and Hcy levels in diabetic patients with LVDD suggest an association between homocysteinemia and increased NT-proBNP secretion. Our data indicate that NT-proBNP may be a simple screening tool to select diabetic patients with LVDD requiring further examination with echocardiography. © 2009 Elsevier Ireland Ltd. All rights reserved.