One-week triple therapies for Helicobacter pylori eradication [Helicobacter pylori eradikasyonunda bit haftalik uclu tedaviler]

Studies have shown that omeprazole plus antibiotic treatments are effective in Helicobacter pylori (H.pylori) eradication. But, the optimal drug regimen for H.pylori infection remains uncertain. In this study, 94 H.pylori-positive patients with duodenal ulcer or non-ulcer dyspepsia were examined to investigate the efficacy of one-week triple therapies consisting of omeprazole (O), clarithromycin (C), and amoxicillin (A) or metronidazole (M). The patients were treated with either OAC500 OAC250 or OMC500 combinations for one week. Eighty-six cases completed he study. H.pylori eradication was achieved in 93.3%, 93.1% and 88.9% of the patients in OAC500, OAC250 and OMC500 treatment groups, respectively. Side effects occured at a rate of 33.3%, 10.3% and 22.2%, respectively. No patient discontinued treatment due to adverse reactions. In conclusion, one-week OAC500, OAC250 and OMC500 therapies are highly efficient in H.pylori eradication. Side effects occur less frequently in patients treated with OAC250. One-week OAC250 combination may become the treatment of choice for eradication of H.pylori.